The Correlated Beta Dose Optimisation Approach: Optimal Vaccine Dosing Using Mathematical Modelling and Adaptive Trial Design

Mathematical modelling methods and adaptive trial design are likely to be effective for optimising vaccine dose but are not yet commonly used. This may be due to uncertainty with regard to the correct choice of parametric model for dose-efficacy or dose-toxicity. Non-parametric models have previousl...

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Detalles Bibliográficos
Autores principales: Benest, John, Rhodes, Sophie, Evans, Thomas G., White, Richard G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693615/
https://www.ncbi.nlm.nih.gov/pubmed/36366347
http://dx.doi.org/10.3390/vaccines10111838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693615/
https://www.ncbi.nlm.nih.gov/pubmed/36366347
http://dx.doi.org/10.3390/vaccines10111838

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