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The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for Coronavirus
After the outbreak of SARS-CoV-2 by the end of 2019, the vaccine development strategies became a worldwide priority. Furthermore, the appearances of novel SARS-CoV-2 variants challenge researchers to develop new pharmacological or preventive strategies. However, vaccines still represent an efficient...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693616/ https://www.ncbi.nlm.nih.gov/pubmed/36366353 http://dx.doi.org/10.3390/vaccines10111844 |
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author | García-Machorro, Jazmín Ramírez-Salinas, Gema Lizbeth Martinez-Archundia, Marlet Correa-Basurto, José |
author_facet | García-Machorro, Jazmín Ramírez-Salinas, Gema Lizbeth Martinez-Archundia, Marlet Correa-Basurto, José |
author_sort | García-Machorro, Jazmín |
collection | PubMed |
description | After the outbreak of SARS-CoV-2 by the end of 2019, the vaccine development strategies became a worldwide priority. Furthermore, the appearances of novel SARS-CoV-2 variants challenge researchers to develop new pharmacological or preventive strategies. However, vaccines still represent an efficient way to control the SARS-CoV-2 pandemic worldwide. This review describes the importance of bioinformatic and immunoinformatic tools (in silico) for guide vaccine design. In silico strategies permit the identification of epitopes (immunogenic peptides) which could be used as potential vaccines, as well as nonacarriers such as: vector viral based vaccines, RNA-based vaccines and dendrimers through immunoinformatics. Currently, nucleic acid and protein sequential as well structural analyses through bioinformatic tools allow us to get immunogenic epitopes which can induce immune response alone or in complex with nanocarriers. One of the advantages of in silico techniques is that they facilitate the identification of epitopes, while accelerating the process and helping to economize some stages of the development of safe vaccines. |
format | Online Article Text |
id | pubmed-9693616 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96936162022-11-26 The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for Coronavirus García-Machorro, Jazmín Ramírez-Salinas, Gema Lizbeth Martinez-Archundia, Marlet Correa-Basurto, José Vaccines (Basel) Review After the outbreak of SARS-CoV-2 by the end of 2019, the vaccine development strategies became a worldwide priority. Furthermore, the appearances of novel SARS-CoV-2 variants challenge researchers to develop new pharmacological or preventive strategies. However, vaccines still represent an efficient way to control the SARS-CoV-2 pandemic worldwide. This review describes the importance of bioinformatic and immunoinformatic tools (in silico) for guide vaccine design. In silico strategies permit the identification of epitopes (immunogenic peptides) which could be used as potential vaccines, as well as nonacarriers such as: vector viral based vaccines, RNA-based vaccines and dendrimers through immunoinformatics. Currently, nucleic acid and protein sequential as well structural analyses through bioinformatic tools allow us to get immunogenic epitopes which can induce immune response alone or in complex with nanocarriers. One of the advantages of in silico techniques is that they facilitate the identification of epitopes, while accelerating the process and helping to economize some stages of the development of safe vaccines. MDPI 2022-10-31 /pmc/articles/PMC9693616/ /pubmed/36366353 http://dx.doi.org/10.3390/vaccines10111844 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review García-Machorro, Jazmín Ramírez-Salinas, Gema Lizbeth Martinez-Archundia, Marlet Correa-Basurto, José The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for Coronavirus |
title | The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for Coronavirus |
title_full | The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for Coronavirus |
title_fullStr | The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for Coronavirus |
title_full_unstemmed | The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for Coronavirus |
title_short | The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for Coronavirus |
title_sort | advantage of using immunoinformatic tools on vaccine design and development for coronavirus |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693616/ https://www.ncbi.nlm.nih.gov/pubmed/36366353 http://dx.doi.org/10.3390/vaccines10111844 |
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