Cargando…

Self-expanding metal stent placement and pathological alterations among obstructive colorectal cancer cases

BACKGROUND: Experimental studies suggest that self-expanding metal stents (SEMSs) enhance the aggressive behavior of obstructive colorectal cancer. The influence of SEMS placement on pathological alterations remains to be elucidated. AIM: To determine whether SEMS placement is associated with molecu...

Descripción completa

Detalles Bibliográficos
Autores principales: Kosumi, Keisuke, Mima, Kosuke, Kanemitsu, Kosuke, Tajiri, Takuya, Takematsu, Toru, Sakamoto, Yuki, Inoue, Mitsuhiro, Miyamoto, Yuji, Mizumoto, Takao, Kubota, Tatsuo, Miyanari, Nobutomo, Baba, Hideo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693689/
https://www.ncbi.nlm.nih.gov/pubmed/36438885
http://dx.doi.org/10.4253/wjge.v14.i11.704
_version_ 1784837606292324352
author Kosumi, Keisuke
Mima, Kosuke
Kanemitsu, Kosuke
Tajiri, Takuya
Takematsu, Toru
Sakamoto, Yuki
Inoue, Mitsuhiro
Miyamoto, Yuji
Mizumoto, Takao
Kubota, Tatsuo
Miyanari, Nobutomo
Baba, Hideo
author_facet Kosumi, Keisuke
Mima, Kosuke
Kanemitsu, Kosuke
Tajiri, Takuya
Takematsu, Toru
Sakamoto, Yuki
Inoue, Mitsuhiro
Miyamoto, Yuji
Mizumoto, Takao
Kubota, Tatsuo
Miyanari, Nobutomo
Baba, Hideo
author_sort Kosumi, Keisuke
collection PubMed
description BACKGROUND: Experimental studies suggest that self-expanding metal stents (SEMSs) enhance the aggressive behavior of obstructive colorectal cancer. The influence of SEMS placement on pathological alterations remains to be elucidated. AIM: To determine whether SEMS placement is associated with molecular or pathological features of colorectal carcinoma tissues. METHODS: Using a nonbiased molecular pathological epidemiology database of patients with obstructive colorectal cancers, we examined the association of SEMS placement with molecular or pathological features, including tumor size, histological type, American Joint Committee on Cancer (AJCC)-pTNM stage, and mutation statuses in colorectal cancer tissues compared with the use of transanal tubes. A multivariable logistic regression model was used to adjust for potential confounders. RESULTS: SEMS placement was significantly associated with venous invasion (P < 0.01), but not with the other features examined, including tumor size, disease stage, mutation status, and lymphatic invasion. In both the univariable and multivariable models with adjustment for potential factors including tumor location, histological type, and AJCC-pT stage, SEMS placement was significantly associated with severe venous invasion (P < 0.01). For the outcome category of severe venous invasion, the multivariable odds ratio for SEMS placement relative to transanal tube placement was 19.4 (95% confidence interval: 5.24–96.2). No significant differences of disease-free survival and overall survival were observed between SEMS and transanal tube groups. CONCLUSION: SEMS placement might be associated with severe venous invasion in colorectal cancer tissue, providing an impetus for further investigations on the pathological alterations by SEMSs in colorectal cancer development.
format Online
Article
Text
id pubmed-9693689
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Baishideng Publishing Group Inc
record_format MEDLINE/PubMed
spelling pubmed-96936892022-11-26 Self-expanding metal stent placement and pathological alterations among obstructive colorectal cancer cases Kosumi, Keisuke Mima, Kosuke Kanemitsu, Kosuke Tajiri, Takuya Takematsu, Toru Sakamoto, Yuki Inoue, Mitsuhiro Miyamoto, Yuji Mizumoto, Takao Kubota, Tatsuo Miyanari, Nobutomo Baba, Hideo World J Gastrointest Endosc Retrospective Study BACKGROUND: Experimental studies suggest that self-expanding metal stents (SEMSs) enhance the aggressive behavior of obstructive colorectal cancer. The influence of SEMS placement on pathological alterations remains to be elucidated. AIM: To determine whether SEMS placement is associated with molecular or pathological features of colorectal carcinoma tissues. METHODS: Using a nonbiased molecular pathological epidemiology database of patients with obstructive colorectal cancers, we examined the association of SEMS placement with molecular or pathological features, including tumor size, histological type, American Joint Committee on Cancer (AJCC)-pTNM stage, and mutation statuses in colorectal cancer tissues compared with the use of transanal tubes. A multivariable logistic regression model was used to adjust for potential confounders. RESULTS: SEMS placement was significantly associated with venous invasion (P < 0.01), but not with the other features examined, including tumor size, disease stage, mutation status, and lymphatic invasion. In both the univariable and multivariable models with adjustment for potential factors including tumor location, histological type, and AJCC-pT stage, SEMS placement was significantly associated with severe venous invasion (P < 0.01). For the outcome category of severe venous invasion, the multivariable odds ratio for SEMS placement relative to transanal tube placement was 19.4 (95% confidence interval: 5.24–96.2). No significant differences of disease-free survival and overall survival were observed between SEMS and transanal tube groups. CONCLUSION: SEMS placement might be associated with severe venous invasion in colorectal cancer tissue, providing an impetus for further investigations on the pathological alterations by SEMSs in colorectal cancer development. Baishideng Publishing Group Inc 2022-11-16 2022-11-16 /pmc/articles/PMC9693689/ /pubmed/36438885 http://dx.doi.org/10.4253/wjge.v14.i11.704 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Retrospective Study
Kosumi, Keisuke
Mima, Kosuke
Kanemitsu, Kosuke
Tajiri, Takuya
Takematsu, Toru
Sakamoto, Yuki
Inoue, Mitsuhiro
Miyamoto, Yuji
Mizumoto, Takao
Kubota, Tatsuo
Miyanari, Nobutomo
Baba, Hideo
Self-expanding metal stent placement and pathological alterations among obstructive colorectal cancer cases
title Self-expanding metal stent placement and pathological alterations among obstructive colorectal cancer cases
title_full Self-expanding metal stent placement and pathological alterations among obstructive colorectal cancer cases
title_fullStr Self-expanding metal stent placement and pathological alterations among obstructive colorectal cancer cases
title_full_unstemmed Self-expanding metal stent placement and pathological alterations among obstructive colorectal cancer cases
title_short Self-expanding metal stent placement and pathological alterations among obstructive colorectal cancer cases
title_sort self-expanding metal stent placement and pathological alterations among obstructive colorectal cancer cases
topic Retrospective Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693689/
https://www.ncbi.nlm.nih.gov/pubmed/36438885
http://dx.doi.org/10.4253/wjge.v14.i11.704
work_keys_str_mv AT kosumikeisuke selfexpandingmetalstentplacementandpathologicalalterationsamongobstructivecolorectalcancercases
AT mimakosuke selfexpandingmetalstentplacementandpathologicalalterationsamongobstructivecolorectalcancercases
AT kanemitsukosuke selfexpandingmetalstentplacementandpathologicalalterationsamongobstructivecolorectalcancercases
AT tajiritakuya selfexpandingmetalstentplacementandpathologicalalterationsamongobstructivecolorectalcancercases
AT takematsutoru selfexpandingmetalstentplacementandpathologicalalterationsamongobstructivecolorectalcancercases
AT sakamotoyuki selfexpandingmetalstentplacementandpathologicalalterationsamongobstructivecolorectalcancercases
AT inouemitsuhiro selfexpandingmetalstentplacementandpathologicalalterationsamongobstructivecolorectalcancercases
AT miyamotoyuji selfexpandingmetalstentplacementandpathologicalalterationsamongobstructivecolorectalcancercases
AT mizumototakao selfexpandingmetalstentplacementandpathologicalalterationsamongobstructivecolorectalcancercases
AT kubotatatsuo selfexpandingmetalstentplacementandpathologicalalterationsamongobstructivecolorectalcancercases
AT miyanarinobutomo selfexpandingmetalstentplacementandpathologicalalterationsamongobstructivecolorectalcancercases
AT babahideo selfexpandingmetalstentplacementandpathologicalalterationsamongobstructivecolorectalcancercases