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Peak width of skeletonized mean diffusivity in cerebral amyloid angiopathy: Spatial signature, cognitive, and neuroimaging associations

BACKGROUND: Peak width of skeletonized mean diffusivity (PSMD) is a promising diffusion tensor imaging (DTI) marker that shows consistent and strong cognitive associations in the context of different cerebral small vessel diseases (cSVD). PURPOSE: Investigate whether PSMD (1) is higher in patients w...

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Autores principales: Zanon Zotin, Maria Clara, Schoemaker, Dorothee, Raposo, Nicolas, Perosa, Valentina, Bretzner, Martin, Sveikata, Lukas, Li, Qi, van Veluw, Susanne J., Horn, Mitchell J., Etherton, Mark R., Charidimou, Andreas, Gurol, M. Edip, Greenberg, Steven M., Duering, Marco, dos Santos, Antonio Carlos, Pontes-Neto, Octavio M., Viswanathan, Anand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693722/
https://www.ncbi.nlm.nih.gov/pubmed/36440281
http://dx.doi.org/10.3389/fnins.2022.1051038
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author Zanon Zotin, Maria Clara
Schoemaker, Dorothee
Raposo, Nicolas
Perosa, Valentina
Bretzner, Martin
Sveikata, Lukas
Li, Qi
van Veluw, Susanne J.
Horn, Mitchell J.
Etherton, Mark R.
Charidimou, Andreas
Gurol, M. Edip
Greenberg, Steven M.
Duering, Marco
dos Santos, Antonio Carlos
Pontes-Neto, Octavio M.
Viswanathan, Anand
author_facet Zanon Zotin, Maria Clara
Schoemaker, Dorothee
Raposo, Nicolas
Perosa, Valentina
Bretzner, Martin
Sveikata, Lukas
Li, Qi
van Veluw, Susanne J.
Horn, Mitchell J.
Etherton, Mark R.
Charidimou, Andreas
Gurol, M. Edip
Greenberg, Steven M.
Duering, Marco
dos Santos, Antonio Carlos
Pontes-Neto, Octavio M.
Viswanathan, Anand
author_sort Zanon Zotin, Maria Clara
collection PubMed
description BACKGROUND: Peak width of skeletonized mean diffusivity (PSMD) is a promising diffusion tensor imaging (DTI) marker that shows consistent and strong cognitive associations in the context of different cerebral small vessel diseases (cSVD). PURPOSE: Investigate whether PSMD (1) is higher in patients with Cerebral Amyloid Angiopathy (CAA) than those with arteriolosclerosis; (2) can capture the anteroposterior distribution of CAA-related abnormalities; (3) shows similar neuroimaging and cognitive associations in comparison to other classical DTI markers, such as average mean diffusivity (MD) and fractional anisotropy (FA). MATERIALS AND METHODS: We analyzed cross-sectional neuroimaging and neuropsychological data from 90 non-demented memory-clinic subjects from a single center. Based on MRI findings, we classified them into probable-CAA (those that fulfilled the modified Boston criteria), subjects with MRI markers of cSVD not attributable to CAA (presumed arteriolosclerosis; cSVD), and subjects without evidence of cSVD on MRI (non-cSVD). We compared total and lobe-specific (frontal and occipital) DTI metrics values across the groups. We used linear regression models to investigate how PSMD, MD, and FA correlate with conventional neuroimaging markers of cSVD and cognitive scores in CAA. RESULTS: PSMD was comparable in probable-CAA (median 4.06 × 10(–4) mm(2)/s) and cSVD (4.07 × 10(–4) mm(2)/s) patients, but higher than in non-cSVD (3.30 × 10(–4) mm(2)/s; p < 0.001) subjects. Occipital-frontal PSMD gradients were higher in probable-CAA patients, and we observed a significant interaction between diagnosis and region on PSMD values [F(2, 87) = 3.887, p = 0.024]. PSMD was mainly associated with white matter hyperintensity volume, whereas MD and FA were also associated with other markers, especially with the burden of perivascular spaces. PSMD correlated with worse executive function (β = −0.581, p < 0.001) and processing speed (β = −0.463, p = 0.003), explaining more variance than other MRI markers. MD and FA were not associated with performance in any cognitive domain. CONCLUSION: PSMD is a promising biomarker of cognitive impairment in CAA that outperforms other conventional and DTI-based neuroimaging markers. Although global PSMD is similarly increased in different forms of cSVD, PSMD’s spatial variations could potentially provide insights into the predominant type of underlying microvascular pathology.
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spelling pubmed-96937222022-11-26 Peak width of skeletonized mean diffusivity in cerebral amyloid angiopathy: Spatial signature, cognitive, and neuroimaging associations Zanon Zotin, Maria Clara Schoemaker, Dorothee Raposo, Nicolas Perosa, Valentina Bretzner, Martin Sveikata, Lukas Li, Qi van Veluw, Susanne J. Horn, Mitchell J. Etherton, Mark R. Charidimou, Andreas Gurol, M. Edip Greenberg, Steven M. Duering, Marco dos Santos, Antonio Carlos Pontes-Neto, Octavio M. Viswanathan, Anand Front Neurosci Neuroscience BACKGROUND: Peak width of skeletonized mean diffusivity (PSMD) is a promising diffusion tensor imaging (DTI) marker that shows consistent and strong cognitive associations in the context of different cerebral small vessel diseases (cSVD). PURPOSE: Investigate whether PSMD (1) is higher in patients with Cerebral Amyloid Angiopathy (CAA) than those with arteriolosclerosis; (2) can capture the anteroposterior distribution of CAA-related abnormalities; (3) shows similar neuroimaging and cognitive associations in comparison to other classical DTI markers, such as average mean diffusivity (MD) and fractional anisotropy (FA). MATERIALS AND METHODS: We analyzed cross-sectional neuroimaging and neuropsychological data from 90 non-demented memory-clinic subjects from a single center. Based on MRI findings, we classified them into probable-CAA (those that fulfilled the modified Boston criteria), subjects with MRI markers of cSVD not attributable to CAA (presumed arteriolosclerosis; cSVD), and subjects without evidence of cSVD on MRI (non-cSVD). We compared total and lobe-specific (frontal and occipital) DTI metrics values across the groups. We used linear regression models to investigate how PSMD, MD, and FA correlate with conventional neuroimaging markers of cSVD and cognitive scores in CAA. RESULTS: PSMD was comparable in probable-CAA (median 4.06 × 10(–4) mm(2)/s) and cSVD (4.07 × 10(–4) mm(2)/s) patients, but higher than in non-cSVD (3.30 × 10(–4) mm(2)/s; p < 0.001) subjects. Occipital-frontal PSMD gradients were higher in probable-CAA patients, and we observed a significant interaction between diagnosis and region on PSMD values [F(2, 87) = 3.887, p = 0.024]. PSMD was mainly associated with white matter hyperintensity volume, whereas MD and FA were also associated with other markers, especially with the burden of perivascular spaces. PSMD correlated with worse executive function (β = −0.581, p < 0.001) and processing speed (β = −0.463, p = 0.003), explaining more variance than other MRI markers. MD and FA were not associated with performance in any cognitive domain. CONCLUSION: PSMD is a promising biomarker of cognitive impairment in CAA that outperforms other conventional and DTI-based neuroimaging markers. Although global PSMD is similarly increased in different forms of cSVD, PSMD’s spatial variations could potentially provide insights into the predominant type of underlying microvascular pathology. Frontiers Media S.A. 2022-11-11 /pmc/articles/PMC9693722/ /pubmed/36440281 http://dx.doi.org/10.3389/fnins.2022.1051038 Text en Copyright © 2022 Zanon Zotin, Schoemaker, Raposo, Perosa, Bretzner, Sveikata, Li, van Veluw, Horn, Etherton, Charidimou, Gurol, Greenberg, Duering, Santos, Pontes-Neto and Viswanathan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zanon Zotin, Maria Clara
Schoemaker, Dorothee
Raposo, Nicolas
Perosa, Valentina
Bretzner, Martin
Sveikata, Lukas
Li, Qi
van Veluw, Susanne J.
Horn, Mitchell J.
Etherton, Mark R.
Charidimou, Andreas
Gurol, M. Edip
Greenberg, Steven M.
Duering, Marco
dos Santos, Antonio Carlos
Pontes-Neto, Octavio M.
Viswanathan, Anand
Peak width of skeletonized mean diffusivity in cerebral amyloid angiopathy: Spatial signature, cognitive, and neuroimaging associations
title Peak width of skeletonized mean diffusivity in cerebral amyloid angiopathy: Spatial signature, cognitive, and neuroimaging associations
title_full Peak width of skeletonized mean diffusivity in cerebral amyloid angiopathy: Spatial signature, cognitive, and neuroimaging associations
title_fullStr Peak width of skeletonized mean diffusivity in cerebral amyloid angiopathy: Spatial signature, cognitive, and neuroimaging associations
title_full_unstemmed Peak width of skeletonized mean diffusivity in cerebral amyloid angiopathy: Spatial signature, cognitive, and neuroimaging associations
title_short Peak width of skeletonized mean diffusivity in cerebral amyloid angiopathy: Spatial signature, cognitive, and neuroimaging associations
title_sort peak width of skeletonized mean diffusivity in cerebral amyloid angiopathy: spatial signature, cognitive, and neuroimaging associations
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693722/
https://www.ncbi.nlm.nih.gov/pubmed/36440281
http://dx.doi.org/10.3389/fnins.2022.1051038
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