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Comparison of the Concordance of Cardiometabolic Diseases and Physical and Laboratory Examination Findings between Monozygotic and Dizygotic Korean Adult Twins: A Cross-Sectional Study Using KoGES HTS Data
This study investigated the contribution of genetic and environmental factors to cardiometabolic diseases (CMDs) by comparing disease concordance in monozygotic and dizygotic twins. This cross-sectional study analyzed 1294 (1040 monozygotic and 254 dizygotic) twin pairs (>20 years) based on the K...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693823/ https://www.ncbi.nlm.nih.gov/pubmed/36432523 http://dx.doi.org/10.3390/nu14224834 |
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author | Kang, Ho Suk Kim, So Young Choi, Hyo Geun Lim, Hyun Kim, Joo-Hee Kim, Ji Hee Cho, Seong-Jin Nam, Eun Sook Min, Kyueng-Whan Park, Ha Young Kim, Nan Young Choi, Younghee Kwon, Mi Jung |
author_facet | Kang, Ho Suk Kim, So Young Choi, Hyo Geun Lim, Hyun Kim, Joo-Hee Kim, Ji Hee Cho, Seong-Jin Nam, Eun Sook Min, Kyueng-Whan Park, Ha Young Kim, Nan Young Choi, Younghee Kwon, Mi Jung |
author_sort | Kang, Ho Suk |
collection | PubMed |
description | This study investigated the contribution of genetic and environmental factors to cardiometabolic diseases (CMDs) by comparing disease concordance in monozygotic and dizygotic twins. This cross-sectional study analyzed 1294 (1040 monozygotic and 254 dizygotic) twin pairs (>20 years) based on the Korean Genome and Epidemiology Study data (2005–2014). The odds ratios of disease concordance were calculated using binomial and multinomial logistic regression models. The occurrence of CMDs (hypertension, hyperlipidemia, type 2 diabetes, cerebral stroke, transient ischemic attack, and ischemic heart disease) and related physical and laboratory levels did not differ between the monozygotic and dizygotic twin groups. The odds for concordance of the presence/absence of CMDs and the likelihood of incident CMD within monozygotic twins were comparable to that of dizygotic twins. The absolute differences in hemoglobin A1c, insulin, low- and high-density lipoprotein cholesterol, total cholesterol, triglycerides, and systolic blood pressure were lower in monozygotic twins than in dizygotic twins. Absolute differences in fasting glucose and diastolic blood pressure did not differ between groups. Although baseline levels of several laboratory parameters related to CMD showed a strong likelihood of heritability in monozygotic twins, CMD phenotype appears to be largely affected by environmental factors. |
format | Online Article Text |
id | pubmed-9693823 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96938232022-11-26 Comparison of the Concordance of Cardiometabolic Diseases and Physical and Laboratory Examination Findings between Monozygotic and Dizygotic Korean Adult Twins: A Cross-Sectional Study Using KoGES HTS Data Kang, Ho Suk Kim, So Young Choi, Hyo Geun Lim, Hyun Kim, Joo-Hee Kim, Ji Hee Cho, Seong-Jin Nam, Eun Sook Min, Kyueng-Whan Park, Ha Young Kim, Nan Young Choi, Younghee Kwon, Mi Jung Nutrients Article This study investigated the contribution of genetic and environmental factors to cardiometabolic diseases (CMDs) by comparing disease concordance in monozygotic and dizygotic twins. This cross-sectional study analyzed 1294 (1040 monozygotic and 254 dizygotic) twin pairs (>20 years) based on the Korean Genome and Epidemiology Study data (2005–2014). The odds ratios of disease concordance were calculated using binomial and multinomial logistic regression models. The occurrence of CMDs (hypertension, hyperlipidemia, type 2 diabetes, cerebral stroke, transient ischemic attack, and ischemic heart disease) and related physical and laboratory levels did not differ between the monozygotic and dizygotic twin groups. The odds for concordance of the presence/absence of CMDs and the likelihood of incident CMD within monozygotic twins were comparable to that of dizygotic twins. The absolute differences in hemoglobin A1c, insulin, low- and high-density lipoprotein cholesterol, total cholesterol, triglycerides, and systolic blood pressure were lower in monozygotic twins than in dizygotic twins. Absolute differences in fasting glucose and diastolic blood pressure did not differ between groups. Although baseline levels of several laboratory parameters related to CMD showed a strong likelihood of heritability in monozygotic twins, CMD phenotype appears to be largely affected by environmental factors. MDPI 2022-11-15 /pmc/articles/PMC9693823/ /pubmed/36432523 http://dx.doi.org/10.3390/nu14224834 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kang, Ho Suk Kim, So Young Choi, Hyo Geun Lim, Hyun Kim, Joo-Hee Kim, Ji Hee Cho, Seong-Jin Nam, Eun Sook Min, Kyueng-Whan Park, Ha Young Kim, Nan Young Choi, Younghee Kwon, Mi Jung Comparison of the Concordance of Cardiometabolic Diseases and Physical and Laboratory Examination Findings between Monozygotic and Dizygotic Korean Adult Twins: A Cross-Sectional Study Using KoGES HTS Data |
title | Comparison of the Concordance of Cardiometabolic Diseases and Physical and Laboratory Examination Findings between Monozygotic and Dizygotic Korean Adult Twins: A Cross-Sectional Study Using KoGES HTS Data |
title_full | Comparison of the Concordance of Cardiometabolic Diseases and Physical and Laboratory Examination Findings between Monozygotic and Dizygotic Korean Adult Twins: A Cross-Sectional Study Using KoGES HTS Data |
title_fullStr | Comparison of the Concordance of Cardiometabolic Diseases and Physical and Laboratory Examination Findings between Monozygotic and Dizygotic Korean Adult Twins: A Cross-Sectional Study Using KoGES HTS Data |
title_full_unstemmed | Comparison of the Concordance of Cardiometabolic Diseases and Physical and Laboratory Examination Findings between Monozygotic and Dizygotic Korean Adult Twins: A Cross-Sectional Study Using KoGES HTS Data |
title_short | Comparison of the Concordance of Cardiometabolic Diseases and Physical and Laboratory Examination Findings between Monozygotic and Dizygotic Korean Adult Twins: A Cross-Sectional Study Using KoGES HTS Data |
title_sort | comparison of the concordance of cardiometabolic diseases and physical and laboratory examination findings between monozygotic and dizygotic korean adult twins: a cross-sectional study using koges hts data |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693823/ https://www.ncbi.nlm.nih.gov/pubmed/36432523 http://dx.doi.org/10.3390/nu14224834 |
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