Cargando…

Comparison of the Concordance of Cardiometabolic Diseases and Physical and Laboratory Examination Findings between Monozygotic and Dizygotic Korean Adult Twins: A Cross-Sectional Study Using KoGES HTS Data

This study investigated the contribution of genetic and environmental factors to cardiometabolic diseases (CMDs) by comparing disease concordance in monozygotic and dizygotic twins. This cross-sectional study analyzed 1294 (1040 monozygotic and 254 dizygotic) twin pairs (>20 years) based on the K...

Descripción completa

Detalles Bibliográficos
Autores principales: Kang, Ho Suk, Kim, So Young, Choi, Hyo Geun, Lim, Hyun, Kim, Joo-Hee, Kim, Ji Hee, Cho, Seong-Jin, Nam, Eun Sook, Min, Kyueng-Whan, Park, Ha Young, Kim, Nan Young, Choi, Younghee, Kwon, Mi Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693823/
https://www.ncbi.nlm.nih.gov/pubmed/36432523
http://dx.doi.org/10.3390/nu14224834
_version_ 1784837641141747712
author Kang, Ho Suk
Kim, So Young
Choi, Hyo Geun
Lim, Hyun
Kim, Joo-Hee
Kim, Ji Hee
Cho, Seong-Jin
Nam, Eun Sook
Min, Kyueng-Whan
Park, Ha Young
Kim, Nan Young
Choi, Younghee
Kwon, Mi Jung
author_facet Kang, Ho Suk
Kim, So Young
Choi, Hyo Geun
Lim, Hyun
Kim, Joo-Hee
Kim, Ji Hee
Cho, Seong-Jin
Nam, Eun Sook
Min, Kyueng-Whan
Park, Ha Young
Kim, Nan Young
Choi, Younghee
Kwon, Mi Jung
author_sort Kang, Ho Suk
collection PubMed
description This study investigated the contribution of genetic and environmental factors to cardiometabolic diseases (CMDs) by comparing disease concordance in monozygotic and dizygotic twins. This cross-sectional study analyzed 1294 (1040 monozygotic and 254 dizygotic) twin pairs (>20 years) based on the Korean Genome and Epidemiology Study data (2005–2014). The odds ratios of disease concordance were calculated using binomial and multinomial logistic regression models. The occurrence of CMDs (hypertension, hyperlipidemia, type 2 diabetes, cerebral stroke, transient ischemic attack, and ischemic heart disease) and related physical and laboratory levels did not differ between the monozygotic and dizygotic twin groups. The odds for concordance of the presence/absence of CMDs and the likelihood of incident CMD within monozygotic twins were comparable to that of dizygotic twins. The absolute differences in hemoglobin A1c, insulin, low- and high-density lipoprotein cholesterol, total cholesterol, triglycerides, and systolic blood pressure were lower in monozygotic twins than in dizygotic twins. Absolute differences in fasting glucose and diastolic blood pressure did not differ between groups. Although baseline levels of several laboratory parameters related to CMD showed a strong likelihood of heritability in monozygotic twins, CMD phenotype appears to be largely affected by environmental factors.
format Online
Article
Text
id pubmed-9693823
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96938232022-11-26 Comparison of the Concordance of Cardiometabolic Diseases and Physical and Laboratory Examination Findings between Monozygotic and Dizygotic Korean Adult Twins: A Cross-Sectional Study Using KoGES HTS Data Kang, Ho Suk Kim, So Young Choi, Hyo Geun Lim, Hyun Kim, Joo-Hee Kim, Ji Hee Cho, Seong-Jin Nam, Eun Sook Min, Kyueng-Whan Park, Ha Young Kim, Nan Young Choi, Younghee Kwon, Mi Jung Nutrients Article This study investigated the contribution of genetic and environmental factors to cardiometabolic diseases (CMDs) by comparing disease concordance in monozygotic and dizygotic twins. This cross-sectional study analyzed 1294 (1040 monozygotic and 254 dizygotic) twin pairs (>20 years) based on the Korean Genome and Epidemiology Study data (2005–2014). The odds ratios of disease concordance were calculated using binomial and multinomial logistic regression models. The occurrence of CMDs (hypertension, hyperlipidemia, type 2 diabetes, cerebral stroke, transient ischemic attack, and ischemic heart disease) and related physical and laboratory levels did not differ between the monozygotic and dizygotic twin groups. The odds for concordance of the presence/absence of CMDs and the likelihood of incident CMD within monozygotic twins were comparable to that of dizygotic twins. The absolute differences in hemoglobin A1c, insulin, low- and high-density lipoprotein cholesterol, total cholesterol, triglycerides, and systolic blood pressure were lower in monozygotic twins than in dizygotic twins. Absolute differences in fasting glucose and diastolic blood pressure did not differ between groups. Although baseline levels of several laboratory parameters related to CMD showed a strong likelihood of heritability in monozygotic twins, CMD phenotype appears to be largely affected by environmental factors. MDPI 2022-11-15 /pmc/articles/PMC9693823/ /pubmed/36432523 http://dx.doi.org/10.3390/nu14224834 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kang, Ho Suk
Kim, So Young
Choi, Hyo Geun
Lim, Hyun
Kim, Joo-Hee
Kim, Ji Hee
Cho, Seong-Jin
Nam, Eun Sook
Min, Kyueng-Whan
Park, Ha Young
Kim, Nan Young
Choi, Younghee
Kwon, Mi Jung
Comparison of the Concordance of Cardiometabolic Diseases and Physical and Laboratory Examination Findings between Monozygotic and Dizygotic Korean Adult Twins: A Cross-Sectional Study Using KoGES HTS Data
title Comparison of the Concordance of Cardiometabolic Diseases and Physical and Laboratory Examination Findings between Monozygotic and Dizygotic Korean Adult Twins: A Cross-Sectional Study Using KoGES HTS Data
title_full Comparison of the Concordance of Cardiometabolic Diseases and Physical and Laboratory Examination Findings between Monozygotic and Dizygotic Korean Adult Twins: A Cross-Sectional Study Using KoGES HTS Data
title_fullStr Comparison of the Concordance of Cardiometabolic Diseases and Physical and Laboratory Examination Findings between Monozygotic and Dizygotic Korean Adult Twins: A Cross-Sectional Study Using KoGES HTS Data
title_full_unstemmed Comparison of the Concordance of Cardiometabolic Diseases and Physical and Laboratory Examination Findings between Monozygotic and Dizygotic Korean Adult Twins: A Cross-Sectional Study Using KoGES HTS Data
title_short Comparison of the Concordance of Cardiometabolic Diseases and Physical and Laboratory Examination Findings between Monozygotic and Dizygotic Korean Adult Twins: A Cross-Sectional Study Using KoGES HTS Data
title_sort comparison of the concordance of cardiometabolic diseases and physical and laboratory examination findings between monozygotic and dizygotic korean adult twins: a cross-sectional study using koges hts data
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693823/
https://www.ncbi.nlm.nih.gov/pubmed/36432523
http://dx.doi.org/10.3390/nu14224834
work_keys_str_mv AT kanghosuk comparisonoftheconcordanceofcardiometabolicdiseasesandphysicalandlaboratoryexaminationfindingsbetweenmonozygoticanddizygotickoreanadulttwinsacrosssectionalstudyusingkogeshtsdata
AT kimsoyoung comparisonoftheconcordanceofcardiometabolicdiseasesandphysicalandlaboratoryexaminationfindingsbetweenmonozygoticanddizygotickoreanadulttwinsacrosssectionalstudyusingkogeshtsdata
AT choihyogeun comparisonoftheconcordanceofcardiometabolicdiseasesandphysicalandlaboratoryexaminationfindingsbetweenmonozygoticanddizygotickoreanadulttwinsacrosssectionalstudyusingkogeshtsdata
AT limhyun comparisonoftheconcordanceofcardiometabolicdiseasesandphysicalandlaboratoryexaminationfindingsbetweenmonozygoticanddizygotickoreanadulttwinsacrosssectionalstudyusingkogeshtsdata
AT kimjoohee comparisonoftheconcordanceofcardiometabolicdiseasesandphysicalandlaboratoryexaminationfindingsbetweenmonozygoticanddizygotickoreanadulttwinsacrosssectionalstudyusingkogeshtsdata
AT kimjihee comparisonoftheconcordanceofcardiometabolicdiseasesandphysicalandlaboratoryexaminationfindingsbetweenmonozygoticanddizygotickoreanadulttwinsacrosssectionalstudyusingkogeshtsdata
AT choseongjin comparisonoftheconcordanceofcardiometabolicdiseasesandphysicalandlaboratoryexaminationfindingsbetweenmonozygoticanddizygotickoreanadulttwinsacrosssectionalstudyusingkogeshtsdata
AT nameunsook comparisonoftheconcordanceofcardiometabolicdiseasesandphysicalandlaboratoryexaminationfindingsbetweenmonozygoticanddizygotickoreanadulttwinsacrosssectionalstudyusingkogeshtsdata
AT minkyuengwhan comparisonoftheconcordanceofcardiometabolicdiseasesandphysicalandlaboratoryexaminationfindingsbetweenmonozygoticanddizygotickoreanadulttwinsacrosssectionalstudyusingkogeshtsdata
AT parkhayoung comparisonoftheconcordanceofcardiometabolicdiseasesandphysicalandlaboratoryexaminationfindingsbetweenmonozygoticanddizygotickoreanadulttwinsacrosssectionalstudyusingkogeshtsdata
AT kimnanyoung comparisonoftheconcordanceofcardiometabolicdiseasesandphysicalandlaboratoryexaminationfindingsbetweenmonozygoticanddizygotickoreanadulttwinsacrosssectionalstudyusingkogeshtsdata
AT choiyounghee comparisonoftheconcordanceofcardiometabolicdiseasesandphysicalandlaboratoryexaminationfindingsbetweenmonozygoticanddizygotickoreanadulttwinsacrosssectionalstudyusingkogeshtsdata
AT kwonmijung comparisonoftheconcordanceofcardiometabolicdiseasesandphysicalandlaboratoryexaminationfindingsbetweenmonozygoticanddizygotickoreanadulttwinsacrosssectionalstudyusingkogeshtsdata