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Natural Reno-Protective Agents against Cyclosporine A-Induced Nephrotoxicity: An Overview

CA (cyclosporine A) is a powerful immunosuppressing agent that is commonly utilized for treating various autoimmune illnesses and in transplantation surgery. However, its usage has been significantly restricted because of its unwanted effects, including nephrotoxicity. The pathophysiology of CA-indu...

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Autores principales: Ibrahim, Sabrin R. M., Abdallah, Hossam M., El-Halawany, Ali M., Mohamed, Gamal A., Alhaddad, Aisha A., Samman, Waad A., Alqarni, Ali A., Rizq, Akaber T., Ghazawi, Kholoud F., El-Dine, Riham Salah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693876/
https://www.ncbi.nlm.nih.gov/pubmed/36431872
http://dx.doi.org/10.3390/molecules27227771
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author Ibrahim, Sabrin R. M.
Abdallah, Hossam M.
El-Halawany, Ali M.
Mohamed, Gamal A.
Alhaddad, Aisha A.
Samman, Waad A.
Alqarni, Ali A.
Rizq, Akaber T.
Ghazawi, Kholoud F.
El-Dine, Riham Salah
author_facet Ibrahim, Sabrin R. M.
Abdallah, Hossam M.
El-Halawany, Ali M.
Mohamed, Gamal A.
Alhaddad, Aisha A.
Samman, Waad A.
Alqarni, Ali A.
Rizq, Akaber T.
Ghazawi, Kholoud F.
El-Dine, Riham Salah
author_sort Ibrahim, Sabrin R. M.
collection PubMed
description CA (cyclosporine A) is a powerful immunosuppressing agent that is commonly utilized for treating various autoimmune illnesses and in transplantation surgery. However, its usage has been significantly restricted because of its unwanted effects, including nephrotoxicity. The pathophysiology of CA-induced kidney injury involves inflammation, apoptosis, tubular injury, oxidative stress, and vascular injury. Despite the fact that exact mechanism accountable for CA’s effects is inadequately understood, ROS (reactive oxygen species) involvement has been widely proposed. At present, there are no efficient methods or drugs for treating CA-caused kidney damage. It is noteworthy that diverse natural products have been investigated both in vivo and in-vitro for their possible preventive potential in CA-produced nephrotoxicity. Various extracts and natural metabolites have been found to possess a remarkable potential for restoring CA-produced renal damage and oxidative stress alterations via their anti-apoptosis, anti-inflammatory, and antioxidative potentials. The present article reviews the reported studies that assess the protective capacity of natural products, as well as dietary regimens, in relation to CA-induced nephrotoxicity. Thus, the present study presents novel ideas for designing and developing more efficient prophylactic or remedial strategies versus CA passive influences.
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spelling pubmed-96938762022-11-26 Natural Reno-Protective Agents against Cyclosporine A-Induced Nephrotoxicity: An Overview Ibrahim, Sabrin R. M. Abdallah, Hossam M. El-Halawany, Ali M. Mohamed, Gamal A. Alhaddad, Aisha A. Samman, Waad A. Alqarni, Ali A. Rizq, Akaber T. Ghazawi, Kholoud F. El-Dine, Riham Salah Molecules Review CA (cyclosporine A) is a powerful immunosuppressing agent that is commonly utilized for treating various autoimmune illnesses and in transplantation surgery. However, its usage has been significantly restricted because of its unwanted effects, including nephrotoxicity. The pathophysiology of CA-induced kidney injury involves inflammation, apoptosis, tubular injury, oxidative stress, and vascular injury. Despite the fact that exact mechanism accountable for CA’s effects is inadequately understood, ROS (reactive oxygen species) involvement has been widely proposed. At present, there are no efficient methods or drugs for treating CA-caused kidney damage. It is noteworthy that diverse natural products have been investigated both in vivo and in-vitro for their possible preventive potential in CA-produced nephrotoxicity. Various extracts and natural metabolites have been found to possess a remarkable potential for restoring CA-produced renal damage and oxidative stress alterations via their anti-apoptosis, anti-inflammatory, and antioxidative potentials. The present article reviews the reported studies that assess the protective capacity of natural products, as well as dietary regimens, in relation to CA-induced nephrotoxicity. Thus, the present study presents novel ideas for designing and developing more efficient prophylactic or remedial strategies versus CA passive influences. MDPI 2022-11-11 /pmc/articles/PMC9693876/ /pubmed/36431872 http://dx.doi.org/10.3390/molecules27227771 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ibrahim, Sabrin R. M.
Abdallah, Hossam M.
El-Halawany, Ali M.
Mohamed, Gamal A.
Alhaddad, Aisha A.
Samman, Waad A.
Alqarni, Ali A.
Rizq, Akaber T.
Ghazawi, Kholoud F.
El-Dine, Riham Salah
Natural Reno-Protective Agents against Cyclosporine A-Induced Nephrotoxicity: An Overview
title Natural Reno-Protective Agents against Cyclosporine A-Induced Nephrotoxicity: An Overview
title_full Natural Reno-Protective Agents against Cyclosporine A-Induced Nephrotoxicity: An Overview
title_fullStr Natural Reno-Protective Agents against Cyclosporine A-Induced Nephrotoxicity: An Overview
title_full_unstemmed Natural Reno-Protective Agents against Cyclosporine A-Induced Nephrotoxicity: An Overview
title_short Natural Reno-Protective Agents against Cyclosporine A-Induced Nephrotoxicity: An Overview
title_sort natural reno-protective agents against cyclosporine a-induced nephrotoxicity: an overview
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693876/
https://www.ncbi.nlm.nih.gov/pubmed/36431872
http://dx.doi.org/10.3390/molecules27227771
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