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Olfactory Function and Diffusion Tensor Imaging as Markers of Mild Cognitive Impairment in Early Stages of Parkinson's Disease
Parkinson's disease (PD) is a neurodegenerative disorder that is typified by motor signs and symptoms but can also lead to significant cognitive impairment and dementia Parkinson's Disease Dementia (PDD). While dementia is considered a nonmotor feature of PD that typically occurs later, in...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693894/ https://www.ncbi.nlm.nih.gov/pubmed/34841903 http://dx.doi.org/10.1177/15500594211058263 |
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author | Stewart, Sophie A. Pimer, Laura Fisk, John D. Rusak, Benjamin Leslie, Ron A. Eskes, Gail Schoffer, Kerrie McKelvey, J. Roger Rolheiser, Tyler Khan, M. Naeem Robertson, Harold Good, Kimberley P. |
author_facet | Stewart, Sophie A. Pimer, Laura Fisk, John D. Rusak, Benjamin Leslie, Ron A. Eskes, Gail Schoffer, Kerrie McKelvey, J. Roger Rolheiser, Tyler Khan, M. Naeem Robertson, Harold Good, Kimberley P. |
author_sort | Stewart, Sophie A. |
collection | PubMed |
description | Parkinson's disease (PD) is a neurodegenerative disorder that is typified by motor signs and symptoms but can also lead to significant cognitive impairment and dementia Parkinson's Disease Dementia (PDD). While dementia is considered a nonmotor feature of PD that typically occurs later, individuals with PD may experience mild cognitive impairment (PD-MCI) earlier in the disease course. Olfactory deficit (OD) is considered another nonmotor symptom of PD and often presents even before the motor signs and diagnosis of PD. We examined potential links among cognitive impairment, olfactory functioning, and white matter integrity of olfactory brain regions in persons with early-stage PD. Cognitive tests were used to establish groups with PD-MCI and with normal cognition (PD-NC). Olfactory functioning was examined using the University of Pennsylvania Smell Identification Test (UPSIT) while the white matter integrity of the anterior olfactory structures (AOS) was examined using magnetic resonance imaging (MRI) diffusion tensor imaging (DTI) analysis. Those with PD-MCI demonstrated poorer olfactory functioning and abnormalities based on all DTI parameters in the AOS, relative to PD-NC individuals. OD and microstructural changes in the AOS of individuals with PD may serve as additional biological markers of PD-MCI. |
format | Online Article Text |
id | pubmed-9693894 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-96938942022-11-26 Olfactory Function and Diffusion Tensor Imaging as Markers of Mild Cognitive Impairment in Early Stages of Parkinson's Disease Stewart, Sophie A. Pimer, Laura Fisk, John D. Rusak, Benjamin Leslie, Ron A. Eskes, Gail Schoffer, Kerrie McKelvey, J. Roger Rolheiser, Tyler Khan, M. Naeem Robertson, Harold Good, Kimberley P. Clin EEG Neurosci Special Issue: Mild Cognitive Impairment Parkinson's disease (PD) is a neurodegenerative disorder that is typified by motor signs and symptoms but can also lead to significant cognitive impairment and dementia Parkinson's Disease Dementia (PDD). While dementia is considered a nonmotor feature of PD that typically occurs later, individuals with PD may experience mild cognitive impairment (PD-MCI) earlier in the disease course. Olfactory deficit (OD) is considered another nonmotor symptom of PD and often presents even before the motor signs and diagnosis of PD. We examined potential links among cognitive impairment, olfactory functioning, and white matter integrity of olfactory brain regions in persons with early-stage PD. Cognitive tests were used to establish groups with PD-MCI and with normal cognition (PD-NC). Olfactory functioning was examined using the University of Pennsylvania Smell Identification Test (UPSIT) while the white matter integrity of the anterior olfactory structures (AOS) was examined using magnetic resonance imaging (MRI) diffusion tensor imaging (DTI) analysis. Those with PD-MCI demonstrated poorer olfactory functioning and abnormalities based on all DTI parameters in the AOS, relative to PD-NC individuals. OD and microstructural changes in the AOS of individuals with PD may serve as additional biological markers of PD-MCI. SAGE Publications 2021-11-29 2023-01 /pmc/articles/PMC9693894/ /pubmed/34841903 http://dx.doi.org/10.1177/15500594211058263 Text en © EEG and Clinical Neuroscience Society (ECNS) 2021 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Special Issue: Mild Cognitive Impairment Stewart, Sophie A. Pimer, Laura Fisk, John D. Rusak, Benjamin Leslie, Ron A. Eskes, Gail Schoffer, Kerrie McKelvey, J. Roger Rolheiser, Tyler Khan, M. Naeem Robertson, Harold Good, Kimberley P. Olfactory Function and Diffusion Tensor Imaging as Markers of Mild Cognitive Impairment in Early Stages of Parkinson's Disease |
title | Olfactory Function and Diffusion Tensor Imaging as Markers of Mild Cognitive Impairment in Early Stages of Parkinson's Disease |
title_full | Olfactory Function and Diffusion Tensor Imaging as Markers of Mild Cognitive Impairment in Early Stages of Parkinson's Disease |
title_fullStr | Olfactory Function and Diffusion Tensor Imaging as Markers of Mild Cognitive Impairment in Early Stages of Parkinson's Disease |
title_full_unstemmed | Olfactory Function and Diffusion Tensor Imaging as Markers of Mild Cognitive Impairment in Early Stages of Parkinson's Disease |
title_short | Olfactory Function and Diffusion Tensor Imaging as Markers of Mild Cognitive Impairment in Early Stages of Parkinson's Disease |
title_sort | olfactory function and diffusion tensor imaging as markers of mild cognitive impairment in early stages of parkinson's disease |
topic | Special Issue: Mild Cognitive Impairment |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693894/ https://www.ncbi.nlm.nih.gov/pubmed/34841903 http://dx.doi.org/10.1177/15500594211058263 |
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