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Antiviral Potential of Natural Resources against Influenza Virus Infections
Influenza is a severe contagious disease caused by influenza A and B viruses. The WHO estimates that annual outbreaks lead to 3–5 million severe infections of which approximately 10% lead to the death of the patient. While vaccination is the cornerstone of prevention, antiviral drugs represent the m...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693975/ https://www.ncbi.nlm.nih.gov/pubmed/36366550 http://dx.doi.org/10.3390/v14112452 |
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author | Eichberg, Johanna Maiworm, Elena Oberpaul, Markus Czudai-Matwich, Volker Lüddecke, Tim Vilcinskas, Andreas Hardes, Kornelia |
author_facet | Eichberg, Johanna Maiworm, Elena Oberpaul, Markus Czudai-Matwich, Volker Lüddecke, Tim Vilcinskas, Andreas Hardes, Kornelia |
author_sort | Eichberg, Johanna |
collection | PubMed |
description | Influenza is a severe contagious disease caused by influenza A and B viruses. The WHO estimates that annual outbreaks lead to 3–5 million severe infections of which approximately 10% lead to the death of the patient. While vaccination is the cornerstone of prevention, antiviral drugs represent the most important treatment option of acute infections. Only two classes of drugs are currently approved for the treatment of influenza in numerous countries: M2 channel blockers and neuraminidase inhibitors. In some countries, additional compounds such as the recently developed cap-dependent endonuclease inhibitor baloxavir marboxil or the polymerase inhibitor favipiravir are available. However, many of these compounds suffer from poor efficacy, if not applied early after infection. Furthermore, many influenza strains have developed resistances and lost susceptibility to these compounds. As a result, there is an urgent need to develop new anti-influenza drugs against a broad spectrum of subtypes. Natural products have made an important contribution to the development of new lead structures, particularly in the field of infectious diseases. Therefore, this article aims to review the research on the identification of novel lead structures isolated from natural resources suitable to treat influenza infections. |
format | Online Article Text |
id | pubmed-9693975 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96939752022-11-26 Antiviral Potential of Natural Resources against Influenza Virus Infections Eichberg, Johanna Maiworm, Elena Oberpaul, Markus Czudai-Matwich, Volker Lüddecke, Tim Vilcinskas, Andreas Hardes, Kornelia Viruses Review Influenza is a severe contagious disease caused by influenza A and B viruses. The WHO estimates that annual outbreaks lead to 3–5 million severe infections of which approximately 10% lead to the death of the patient. While vaccination is the cornerstone of prevention, antiviral drugs represent the most important treatment option of acute infections. Only two classes of drugs are currently approved for the treatment of influenza in numerous countries: M2 channel blockers and neuraminidase inhibitors. In some countries, additional compounds such as the recently developed cap-dependent endonuclease inhibitor baloxavir marboxil or the polymerase inhibitor favipiravir are available. However, many of these compounds suffer from poor efficacy, if not applied early after infection. Furthermore, many influenza strains have developed resistances and lost susceptibility to these compounds. As a result, there is an urgent need to develop new anti-influenza drugs against a broad spectrum of subtypes. Natural products have made an important contribution to the development of new lead structures, particularly in the field of infectious diseases. Therefore, this article aims to review the research on the identification of novel lead structures isolated from natural resources suitable to treat influenza infections. MDPI 2022-11-05 /pmc/articles/PMC9693975/ /pubmed/36366550 http://dx.doi.org/10.3390/v14112452 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Eichberg, Johanna Maiworm, Elena Oberpaul, Markus Czudai-Matwich, Volker Lüddecke, Tim Vilcinskas, Andreas Hardes, Kornelia Antiviral Potential of Natural Resources against Influenza Virus Infections |
title | Antiviral Potential of Natural Resources against Influenza Virus Infections |
title_full | Antiviral Potential of Natural Resources against Influenza Virus Infections |
title_fullStr | Antiviral Potential of Natural Resources against Influenza Virus Infections |
title_full_unstemmed | Antiviral Potential of Natural Resources against Influenza Virus Infections |
title_short | Antiviral Potential of Natural Resources against Influenza Virus Infections |
title_sort | antiviral potential of natural resources against influenza virus infections |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693975/ https://www.ncbi.nlm.nih.gov/pubmed/36366550 http://dx.doi.org/10.3390/v14112452 |
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