TFEB acetylation promotes lysosome biogenesis and ameliorates Alzheimer’s disease–relevant phenotypes in mice

Lysosomes are one of the major centers for regulating cargo degradation and protein quality control. Transcription factor EB (TFEB)–promoted lysosome biogenesis enhances lysosome-mediated degradation and alleviates neurodegenerative diseases, but the mechanisms underlying TFEB modification and activ...

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Detalles Bibliográficos
Autores principales: Li, Tianyou, Yin, Limin, Kang, Xinyi, Xue, Wenlong, Wang, Ning, Zhang, Jie, Yuan, Ping, Lin, Lingxi, Li, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694136/
https://www.ncbi.nlm.nih.gov/pubmed/36441024
http://dx.doi.org/10.1016/j.jbc.2022.102649

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