Cargando…

Pharmaco-Toxicological Assessment of the Combined Cytotoxic Effects of Digoxin and Betulinic Acid in Melanoma Cells

Betulinic acid, a small molecule from pentacyclic triterpenes class, has been widely studied for its antitumor activity, revealing that it induces the apoptosis of tumor cells in a selective manner. In recent years, digoxin, a cardiac glycoside found particularly in the plant species Digitalis lanat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rednic, Robert, Macasoi, Ioana, Pinzaru, Iulia, Dehelean, Cristina Adriana, Tomescu, Mirela-Cleopatra, Susan, Monica, Feier, Horea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694166/ https://www.ncbi.nlm.nih.gov/pubmed/36430989 http://dx.doi.org/10.3390/life12111855

Ejemplares similares

Assessment of Betulinic Acid Cytotoxicity and Mitochondrial Metabolism Impairment in a Human Melanoma Cell Line
por: Coricovac, Dorina, et al.
Publicado: (2021)

Oleogel Formulations for the Topical Delivery of Betulin and Lupeol in Skin Injuries—Preparation, Physicochemical Characterization, and Pharmaco-Toxicological Evaluation
por: Pârvănescu (Pană), Ramona Daniela, et al.
Publicado: (2021)

In Vitro Toxicological Profile of Labetalol-Folic Acid/Folate Co-Administration in H9c2(2-1) and HepaRG Cells
por: Rednic, Robert, et al.
Publicado: (2022)

Antibiotics: Conventional Therapy and Natural Compounds with Antibacterial Activity—A Pharmaco-Toxicological Screening
por: Pancu, Daniel Florin, et al.
Publicado: (2021)

Rutin bioconjugates as potential nutraceutical prodrugs: An in vitro and in ovo toxicological screening
por: Dehelean, Cristina Adriana, et al.
Publicado: (2022)

Investigation of Lupeol as Anti-Melanoma Agent: An In Vitro-In Ovo Perspective
por: Bociort, Flavia, et al.
Publicado: (2021)

In Vitro Assessment of the Synergistic Effect of Aspirin and 5-Fluorouracil in Colorectal Adenocarcinoma Cells
por: Susan, Monica, et al.
Publicado: (2023)

Assessment of the In Vitro Cytotoxic Profile of Two Broad-Spectrum Antibiotics—Tetracycline and Ampicillin—On Pharyngeal Carcinoma Cells
por: Pancu, Daniel Florin, et al.
Publicado: (2022)

High Concentrations of Aspartame Induce Pro-Angiogenic Effects in Ovo and Cytotoxic Effects in HT-29 Human Colorectal Carcinoma Cells
por: Maghiari, Anca Laura, et al.
Publicado: (2020)

Simultaneous and Dose Dependent Melanoma Cytotoxic and Immune Stimulatory Activity of Betulin
por: Pfarr, Kathrin, et al.
Publicado: (2015)

Eugenol: In Vitro and In Ovo Assessment to Explore Cytotoxic Effects on Osteosarcoma and Oropharyngeal Cancer Cells
por: Racea, Robert-Cosmin, et al.
Publicado: (2023)

The Cytotoxic Effects of Betulin-Conjugated Gold Nanoparticles as Stable Formulations in Normal and Melanoma Cells
por: Mioc, Marius, et al.
Publicado: (2018)

Melanin and Melanin-Functionalized Nanoparticles as Promising Tools in Cancer Research—A Review
por: Marcovici, Iasmina, et al.
Publicado: (2022)

Silver Nanocolloids Loaded with Betulinic Acid with Enhanced Antitumor Potential: Physicochemical Characterization and In Vitro Evaluation
por: Pinzaru, Iulia, et al.
Publicado: (2021)

Rutin Exerts Cytotoxic and Senescence-Inducing Properties in Human Melanoma Cells
por: Pinzaru, Iulia, et al.
Publicado: (2021)

New ibuprofen derivatives with thiazolidine-4-one scaffold with improved pharmaco-toxicological profile
por: Vasincu, Ioana-Mirela, et al.
Publicado: (2021)

Controlled Synthesis and Characterization of Micrometric Single Crystalline Magnetite With Superparamagnetic Behavior and Cytocompatibility/Cytotoxicity Assessments
por: Farcas, Claudia Geanina, et al.
Publicado: (2020)

Two Antibiotics, Ampicillin and Tetracycline, Exert Different Effects in HT-29 Colorectal Adenocarcinoma Cells in Terms of Cell Viability and Migration Capacity
por: Hut, Emil-Florin, et al.
Publicado: (2021)

Nicotine Exerts Cytotoxic Effects in a Panel of Healthy Cell Lines and Strong Irritating Potential on Blood Vessels
por: Chioran, Doina, et al.
Publicado: (2022)

Study of the betulin enriched birch bark extracts effects on human carcinoma cells and ear inflammation
por: Dehelean, Cristina A, et al.
Publicado: (2012)

Thermosensitive Betulinic Acid-Loaded Magnetoliposomes: A Promising Antitumor Potential for Highly Aggressive Human Breast Adenocarcinoma Cells Under Hyperthermic Conditions
por: Farcas, Claudia Geanina, et al.
Publicado: (2020)

In Vitro Evaluation of the Antimicrobial Ability and Cytotoxicity on Two Melanoma Cell Lines of a Benzylamide Derivative of Maslinic Acid
por: Pavel, Ioana Zinuca, et al.
Publicado: (2016)

Design, synthesis and pharmaco-toxicological assessment of 5-mercapto-1,2,4-triazole derivatives with antibacterial and antiproliferative activity
por: Mioc, Marius, et al.
Publicado: (2017)

Partial Reversible Inhibition of Enzymes and Its Metabolic and Pharmaco-Toxicological Implications
por: Masson, Patrick, et al.
Publicado: (2023)

Comparative Evaluation of the Potential Antitumor of Helleborus purpurascens in Skin and Breast Cancer
por: Pilut, Ciprian Nicolae, et al.
Publicado: (2022)

SARS-CoV-2: Repurposed Drugs and Novel Therapeutic Approaches—Insights into Chemical Structure—Biological Activity and Toxicological Screening
por: Dehelean, Cristina Adriana, et al.
Publicado: (2020)

Biocompatible Colloidal Suspensions Based on Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Toxicological Profile
por: Coricovac, Dorina-Elena, et al.
Publicado: (2017)

The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco-Toxicological Problems
por: Firenzuoli, F., et al.
Publicado: (2008)

The Predictive Value of Endothelial Inflammatory Markers in the Onset of Schizophrenia
por: Radu, Gabriela, et al.
Publicado: (2020)

High cytotoxicity of betulin towards fish and murine fibroblasts: Is betulin safe for nonneoplastic cells?
por: Małaczewska, Joanna, et al.
Publicado: (2021)

Cutaneous Melanoma—A Long Road from Experimental Models to Clinical Outcome: A Review
por: Coricovac, Dorina, et al.
Publicado: (2018)

Toxicological Assessment of an Acrylic Removable Orthodontic Appliance Using 2D and 3D In Vitro Methods
por: Dinu, Stefania, et al.
Publicado: (2022)

Betulin Phosphonates; Synthesis, Structure, and Cytotoxic Activity
por: Chrobak, Elwira, et al.
Publicado: (2016)

The Anti-Melanoma Effect of Betulinic Acid Functionalized Gold Nanoparticles: A Mechanistic In Vitro Approach
por: Ghiulai, Roxana, et al.
Publicado: (2022)

Fetal Tachyarrhythmia Management from Digoxin to Amiodarone—A Review
por: Gozar, Liliana, et al.
Publicado: (2022)

Vegetal Compounds as Sources of Prophylactic and Therapeutic Agents in Dentistry
por: Milutinovici, Raluca-Adriana, et al.
Publicado: (2021)

Raman-guided subcellular pharmaco-metabolomics for metastatic melanoma cells
por: Du, Jiajun, et al.
Publicado: (2020)

Proniosomal Gel for Topical Delivery of Rutin: Preparation, Physicochemical Characterization and In Vitro Toxicological Profile Using 3D Reconstructed Human Epidermis Tissue and 2D Cells
por: Pinzaru, Iulia, et al.
Publicado: (2021)

A robust reprogramming strategy for generating hepatocyte-like cells usable in pharmaco-toxicological studies
por: Garcia-Llorens, Guillem, et al.
Publicado: (2023)

Cocrystal Formation of Betulinic Acid and Ascorbic Acid: Synthesis, Physico-Chemical Assessment, Antioxidant, and Antiproliferative Activity
por: Nicolov, Mirela, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_0dm21tudpcjd6domhemp1bajl9