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SNH Amidation of 5-Nitroisoquinoline: Access to Nitro- and Nitroso Derivatives of Amides and Ureas on the Basis of Isoquinoline

For the first time, amides and ureas based on both 5-nitroisoquinoline and 5-nitrosoisoquinoline were obtained by direct nucleophilic substitution of hydrogen in the 5-nitroisoquinoline molecule. In the case of urea and monosubstituted ureas, only 5-nitrosoisoquinoline-6-amine is formed under anhydr...

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Autores principales: Avakyan, Elena K., Borovleva, Anastasia A., Pobedinskaya, Diana Yu., Demidov, Oleg P., Ermolenko, Artem P., Larin, Alexander N., Borovlev, Ivan V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694180/
https://www.ncbi.nlm.nih.gov/pubmed/36431962
http://dx.doi.org/10.3390/molecules27227862
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author Avakyan, Elena K.
Borovleva, Anastasia A.
Pobedinskaya, Diana Yu.
Demidov, Oleg P.
Ermolenko, Artem P.
Larin, Alexander N.
Borovlev, Ivan V.
author_facet Avakyan, Elena K.
Borovleva, Anastasia A.
Pobedinskaya, Diana Yu.
Demidov, Oleg P.
Ermolenko, Artem P.
Larin, Alexander N.
Borovlev, Ivan V.
author_sort Avakyan, Elena K.
collection PubMed
description For the first time, amides and ureas based on both 5-nitroisoquinoline and 5-nitrosoisoquinoline were obtained by direct nucleophilic substitution of hydrogen in the 5-nitroisoquinoline molecule. In the case of urea and monosubstituted ureas, only 5-nitrosoisoquinoline-6-amine is formed under anhydrous conditions.
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spelling pubmed-96941802022-11-26 SNH Amidation of 5-Nitroisoquinoline: Access to Nitro- and Nitroso Derivatives of Amides and Ureas on the Basis of Isoquinoline Avakyan, Elena K. Borovleva, Anastasia A. Pobedinskaya, Diana Yu. Demidov, Oleg P. Ermolenko, Artem P. Larin, Alexander N. Borovlev, Ivan V. Molecules Article For the first time, amides and ureas based on both 5-nitroisoquinoline and 5-nitrosoisoquinoline were obtained by direct nucleophilic substitution of hydrogen in the 5-nitroisoquinoline molecule. In the case of urea and monosubstituted ureas, only 5-nitrosoisoquinoline-6-amine is formed under anhydrous conditions. MDPI 2022-11-14 /pmc/articles/PMC9694180/ /pubmed/36431962 http://dx.doi.org/10.3390/molecules27227862 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Avakyan, Elena K.
Borovleva, Anastasia A.
Pobedinskaya, Diana Yu.
Demidov, Oleg P.
Ermolenko, Artem P.
Larin, Alexander N.
Borovlev, Ivan V.
SNH Amidation of 5-Nitroisoquinoline: Access to Nitro- and Nitroso Derivatives of Amides and Ureas on the Basis of Isoquinoline
title SNH Amidation of 5-Nitroisoquinoline: Access to Nitro- and Nitroso Derivatives of Amides and Ureas on the Basis of Isoquinoline
title_full SNH Amidation of 5-Nitroisoquinoline: Access to Nitro- and Nitroso Derivatives of Amides and Ureas on the Basis of Isoquinoline
title_fullStr SNH Amidation of 5-Nitroisoquinoline: Access to Nitro- and Nitroso Derivatives of Amides and Ureas on the Basis of Isoquinoline
title_full_unstemmed SNH Amidation of 5-Nitroisoquinoline: Access to Nitro- and Nitroso Derivatives of Amides and Ureas on the Basis of Isoquinoline
title_short SNH Amidation of 5-Nitroisoquinoline: Access to Nitro- and Nitroso Derivatives of Amides and Ureas on the Basis of Isoquinoline
title_sort snh amidation of 5-nitroisoquinoline: access to nitro- and nitroso derivatives of amides and ureas on the basis of isoquinoline
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694180/
https://www.ncbi.nlm.nih.gov/pubmed/36431962
http://dx.doi.org/10.3390/molecules27227862
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