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Epidemiology of Community-Acquired Sepsis: Data from an E-Sepsis Registry of a Tertiary Care Center in South India

The study aims to characterize community-acquired sepsis patients admitted to our 1300-bedded tertiary care hospital in South India from the Surviving Sepsis Campaign (SSC) guideline-compliant e-sepsis registry stratified by focus of infection. The prospective observational study recruited 1009 adul...

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Autores principales: Edathadathil, Fabia, Alex, Soumya, Prasanna, Preetha, Sudhir, Sangita, Balachandran, Sabarish, Moni, Merlin, Menon, Vidya, Sathyapalan, Dipu T., Singh, Sanjeev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694227/
https://www.ncbi.nlm.nih.gov/pubmed/36364977
http://dx.doi.org/10.3390/pathogens11111226
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author Edathadathil, Fabia
Alex, Soumya
Prasanna, Preetha
Sudhir, Sangita
Balachandran, Sabarish
Moni, Merlin
Menon, Vidya
Sathyapalan, Dipu T.
Singh, Sanjeev
author_facet Edathadathil, Fabia
Alex, Soumya
Prasanna, Preetha
Sudhir, Sangita
Balachandran, Sabarish
Moni, Merlin
Menon, Vidya
Sathyapalan, Dipu T.
Singh, Sanjeev
author_sort Edathadathil, Fabia
collection PubMed
description The study aims to characterize community-acquired sepsis patients admitted to our 1300-bedded tertiary care hospital in South India from the Surviving Sepsis Campaign (SSC) guideline-compliant e-sepsis registry stratified by focus of infection. The prospective observational study recruited 1009 adult sepsis patients presenting to the emergency department at the center based on Sepsis-2 criteria for a period of three years. Of the patients, 41% were between 61 and 80 years with a mean age of 57.37 ± 13.5%. A total of 13.5% (136) was under septic shock and in-hospital mortality for the study cohort was 25%. The 3 h and 6 h bundle compliance rates observed were 37% and 49%, respectively, without significant survival benefits. Predictors of mortality among patients with bloodstream infections were septic shock (p = 0.01, OR 2.4, 95% CI 1.23–4.79) and neutrophil-to-lymphocyte ratio (p = 0.008, OR 1.01, 95% CI 1.009–1.066). The presence of Acinetobacter (p = 0.005, OR 4.07, 95% CI 1.37–12.09), Candida non-albicans (p = 0.001, OR16.02, 95% CI 3.0–84.2) and septic shock (p = 0.071, OR 2.5, 95% CI 0.97–6.6) were significant predictors of mortality in patients with community-acquired pneumonia. The registry has proven to be a key data source detailing regional microbial etiology and clinical outcomes of adult sepsis patients, enabling comprehensive evaluation of regional community-acquired sepsis to tailor institutional sepsis treatment protocols.
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spelling pubmed-96942272022-11-26 Epidemiology of Community-Acquired Sepsis: Data from an E-Sepsis Registry of a Tertiary Care Center in South India Edathadathil, Fabia Alex, Soumya Prasanna, Preetha Sudhir, Sangita Balachandran, Sabarish Moni, Merlin Menon, Vidya Sathyapalan, Dipu T. Singh, Sanjeev Pathogens Article The study aims to characterize community-acquired sepsis patients admitted to our 1300-bedded tertiary care hospital in South India from the Surviving Sepsis Campaign (SSC) guideline-compliant e-sepsis registry stratified by focus of infection. The prospective observational study recruited 1009 adult sepsis patients presenting to the emergency department at the center based on Sepsis-2 criteria for a period of three years. Of the patients, 41% were between 61 and 80 years with a mean age of 57.37 ± 13.5%. A total of 13.5% (136) was under septic shock and in-hospital mortality for the study cohort was 25%. The 3 h and 6 h bundle compliance rates observed were 37% and 49%, respectively, without significant survival benefits. Predictors of mortality among patients with bloodstream infections were septic shock (p = 0.01, OR 2.4, 95% CI 1.23–4.79) and neutrophil-to-lymphocyte ratio (p = 0.008, OR 1.01, 95% CI 1.009–1.066). The presence of Acinetobacter (p = 0.005, OR 4.07, 95% CI 1.37–12.09), Candida non-albicans (p = 0.001, OR16.02, 95% CI 3.0–84.2) and septic shock (p = 0.071, OR 2.5, 95% CI 0.97–6.6) were significant predictors of mortality in patients with community-acquired pneumonia. The registry has proven to be a key data source detailing regional microbial etiology and clinical outcomes of adult sepsis patients, enabling comprehensive evaluation of regional community-acquired sepsis to tailor institutional sepsis treatment protocols. MDPI 2022-10-24 /pmc/articles/PMC9694227/ /pubmed/36364977 http://dx.doi.org/10.3390/pathogens11111226 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Edathadathil, Fabia
Alex, Soumya
Prasanna, Preetha
Sudhir, Sangita
Balachandran, Sabarish
Moni, Merlin
Menon, Vidya
Sathyapalan, Dipu T.
Singh, Sanjeev
Epidemiology of Community-Acquired Sepsis: Data from an E-Sepsis Registry of a Tertiary Care Center in South India
title Epidemiology of Community-Acquired Sepsis: Data from an E-Sepsis Registry of a Tertiary Care Center in South India
title_full Epidemiology of Community-Acquired Sepsis: Data from an E-Sepsis Registry of a Tertiary Care Center in South India
title_fullStr Epidemiology of Community-Acquired Sepsis: Data from an E-Sepsis Registry of a Tertiary Care Center in South India
title_full_unstemmed Epidemiology of Community-Acquired Sepsis: Data from an E-Sepsis Registry of a Tertiary Care Center in South India
title_short Epidemiology of Community-Acquired Sepsis: Data from an E-Sepsis Registry of a Tertiary Care Center in South India
title_sort epidemiology of community-acquired sepsis: data from an e-sepsis registry of a tertiary care center in south india
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694227/
https://www.ncbi.nlm.nih.gov/pubmed/36364977
http://dx.doi.org/10.3390/pathogens11111226
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