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Microplastics Exacerbate Cadmium-Induced Kidney Injury by Enhancing Oxidative Stress, Autophagy, Apoptosis, and Fibrosis

Cadmium (Cd) is a potential pathogenic factor in the urinary system that is associated with various kidney diseases. Microplastics (MPs), comprising of plastic particles less than 5 mm in diameter, are a major carrier of contaminants. We applied 10 mg/L particle 5 μm MPs and 50 mg/L CdCl2 in water f...

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Detalles Bibliográficos
Autores principales: Zou, Hui, Chen, Yan, Qu, Huayi, Sun, Jian, Wang, Tao, Ma, Yonggang, Yuan, Yan, Bian, Jianchun, Liu, Zongping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694236/
https://www.ncbi.nlm.nih.gov/pubmed/36430889
http://dx.doi.org/10.3390/ijms232214411
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author Zou, Hui
Chen, Yan
Qu, Huayi
Sun, Jian
Wang, Tao
Ma, Yonggang
Yuan, Yan
Bian, Jianchun
Liu, Zongping
author_facet Zou, Hui
Chen, Yan
Qu, Huayi
Sun, Jian
Wang, Tao
Ma, Yonggang
Yuan, Yan
Bian, Jianchun
Liu, Zongping
author_sort Zou, Hui
collection PubMed
description Cadmium (Cd) is a potential pathogenic factor in the urinary system that is associated with various kidney diseases. Microplastics (MPs), comprising of plastic particles less than 5 mm in diameter, are a major carrier of contaminants. We applied 10 mg/L particle 5 μm MPs and 50 mg/L CdCl2 in water for three months in vivo assay to assess the damaging effects of MPs and Cd exposure on the kidney. In vivo tests showed that MPs exacerbated Cd-induced kidney injury. In addition, the involvement of oxidative stress, autophagy, apoptosis, and fibrosis in the damaging effects of MPs and Cd on mouse kidneys were investigated. The results showed that MPs aggravated Cd-induced kidney injury by enhancing oxidative stress, autophagy, apoptosis, and fibrosis. These findings provide new insights into the toxic effects of MPs on the mouse kidney.
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spelling pubmed-96942362022-11-26 Microplastics Exacerbate Cadmium-Induced Kidney Injury by Enhancing Oxidative Stress, Autophagy, Apoptosis, and Fibrosis Zou, Hui Chen, Yan Qu, Huayi Sun, Jian Wang, Tao Ma, Yonggang Yuan, Yan Bian, Jianchun Liu, Zongping Int J Mol Sci Article Cadmium (Cd) is a potential pathogenic factor in the urinary system that is associated with various kidney diseases. Microplastics (MPs), comprising of plastic particles less than 5 mm in diameter, are a major carrier of contaminants. We applied 10 mg/L particle 5 μm MPs and 50 mg/L CdCl2 in water for three months in vivo assay to assess the damaging effects of MPs and Cd exposure on the kidney. In vivo tests showed that MPs exacerbated Cd-induced kidney injury. In addition, the involvement of oxidative stress, autophagy, apoptosis, and fibrosis in the damaging effects of MPs and Cd on mouse kidneys were investigated. The results showed that MPs aggravated Cd-induced kidney injury by enhancing oxidative stress, autophagy, apoptosis, and fibrosis. These findings provide new insights into the toxic effects of MPs on the mouse kidney. MDPI 2022-11-19 /pmc/articles/PMC9694236/ /pubmed/36430889 http://dx.doi.org/10.3390/ijms232214411 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zou, Hui
Chen, Yan
Qu, Huayi
Sun, Jian
Wang, Tao
Ma, Yonggang
Yuan, Yan
Bian, Jianchun
Liu, Zongping
Microplastics Exacerbate Cadmium-Induced Kidney Injury by Enhancing Oxidative Stress, Autophagy, Apoptosis, and Fibrosis
title Microplastics Exacerbate Cadmium-Induced Kidney Injury by Enhancing Oxidative Stress, Autophagy, Apoptosis, and Fibrosis
title_full Microplastics Exacerbate Cadmium-Induced Kidney Injury by Enhancing Oxidative Stress, Autophagy, Apoptosis, and Fibrosis
title_fullStr Microplastics Exacerbate Cadmium-Induced Kidney Injury by Enhancing Oxidative Stress, Autophagy, Apoptosis, and Fibrosis
title_full_unstemmed Microplastics Exacerbate Cadmium-Induced Kidney Injury by Enhancing Oxidative Stress, Autophagy, Apoptosis, and Fibrosis
title_short Microplastics Exacerbate Cadmium-Induced Kidney Injury by Enhancing Oxidative Stress, Autophagy, Apoptosis, and Fibrosis
title_sort microplastics exacerbate cadmium-induced kidney injury by enhancing oxidative stress, autophagy, apoptosis, and fibrosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694236/
https://www.ncbi.nlm.nih.gov/pubmed/36430889
http://dx.doi.org/10.3390/ijms232214411
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