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Glioma Stem Cells: Novel Data Obtained by Single-Cell Sequencing

Glioma is the most common type of primary CNS tumor, composed of cells that resemble normal glial cells. Recent genetic studies have provided insight into the inter-tumoral heterogeneity of gliomas, resulting in the updated 2021 WHO classification of gliomas. Thorough understanding of inter-tumoral...

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Autores principales: Gisina, Alisa, Kholodenko, Irina, Kim, Yan, Abakumov, Maxim, Lupatov, Alexey, Yarygin, Konstantin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694247/
https://www.ncbi.nlm.nih.gov/pubmed/36430704
http://dx.doi.org/10.3390/ijms232214224
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author Gisina, Alisa
Kholodenko, Irina
Kim, Yan
Abakumov, Maxim
Lupatov, Alexey
Yarygin, Konstantin
author_facet Gisina, Alisa
Kholodenko, Irina
Kim, Yan
Abakumov, Maxim
Lupatov, Alexey
Yarygin, Konstantin
author_sort Gisina, Alisa
collection PubMed
description Glioma is the most common type of primary CNS tumor, composed of cells that resemble normal glial cells. Recent genetic studies have provided insight into the inter-tumoral heterogeneity of gliomas, resulting in the updated 2021 WHO classification of gliomas. Thorough understanding of inter-tumoral heterogeneity has already improved the prognosis and treatment outcomes of some types of gliomas. Currently, the challenge for researchers is to study the intratumoral cell heterogeneity of newly defined glioma subtypes. Cancer stem cells (CSCs) present in gliomas and many other tumors are an example of intratumoral heterogeneity of great importance. In this review, we discuss the modern concept of glioma stem cells and recent single-cell sequencing-driven progress in the research of intratumoral glioma cell heterogeneity. The particular emphasis was placed on the recently revealed variations of the cell composition of the subtypes of the adult-type diffuse gliomas, including astrocytoma, oligodendroglioma and glioblastoma. The novel data explain the inconsistencies in earlier glioma stem cell research and also provide insight into the development of more effective targeted therapy and the cell-based immunotherapy of gliomas. Separate sections are devoted to the description of single-cell sequencing approach and its role in the development of cell-based immunotherapies for glioma.
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spelling pubmed-96942472022-11-26 Glioma Stem Cells: Novel Data Obtained by Single-Cell Sequencing Gisina, Alisa Kholodenko, Irina Kim, Yan Abakumov, Maxim Lupatov, Alexey Yarygin, Konstantin Int J Mol Sci Review Glioma is the most common type of primary CNS tumor, composed of cells that resemble normal glial cells. Recent genetic studies have provided insight into the inter-tumoral heterogeneity of gliomas, resulting in the updated 2021 WHO classification of gliomas. Thorough understanding of inter-tumoral heterogeneity has already improved the prognosis and treatment outcomes of some types of gliomas. Currently, the challenge for researchers is to study the intratumoral cell heterogeneity of newly defined glioma subtypes. Cancer stem cells (CSCs) present in gliomas and many other tumors are an example of intratumoral heterogeneity of great importance. In this review, we discuss the modern concept of glioma stem cells and recent single-cell sequencing-driven progress in the research of intratumoral glioma cell heterogeneity. The particular emphasis was placed on the recently revealed variations of the cell composition of the subtypes of the adult-type diffuse gliomas, including astrocytoma, oligodendroglioma and glioblastoma. The novel data explain the inconsistencies in earlier glioma stem cell research and also provide insight into the development of more effective targeted therapy and the cell-based immunotherapy of gliomas. Separate sections are devoted to the description of single-cell sequencing approach and its role in the development of cell-based immunotherapies for glioma. MDPI 2022-11-17 /pmc/articles/PMC9694247/ /pubmed/36430704 http://dx.doi.org/10.3390/ijms232214224 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gisina, Alisa
Kholodenko, Irina
Kim, Yan
Abakumov, Maxim
Lupatov, Alexey
Yarygin, Konstantin
Glioma Stem Cells: Novel Data Obtained by Single-Cell Sequencing
title Glioma Stem Cells: Novel Data Obtained by Single-Cell Sequencing
title_full Glioma Stem Cells: Novel Data Obtained by Single-Cell Sequencing
title_fullStr Glioma Stem Cells: Novel Data Obtained by Single-Cell Sequencing
title_full_unstemmed Glioma Stem Cells: Novel Data Obtained by Single-Cell Sequencing
title_short Glioma Stem Cells: Novel Data Obtained by Single-Cell Sequencing
title_sort glioma stem cells: novel data obtained by single-cell sequencing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694247/
https://www.ncbi.nlm.nih.gov/pubmed/36430704
http://dx.doi.org/10.3390/ijms232214224
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