Insight into the Spatial Arrangement of the Lysine Tyrosylquinone and Cu(2+) in the Active Site of Lysyl Oxidase-like 2

Lysyl oxidase-2 (LOXL2) is a Cu(2+) and lysine tyrosylquinone (LTQ)-dependent amine oxidase that catalyzes the oxidative deamination of peptidyl lysine and hydroxylysine residues to promote crosslinking of extracellular matrix proteins. LTQ is post-translationally derived from Lys653 and Tyr689, but...

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Detalles Bibliográficos
Autores principales: Meier, Alex A., Moon, Hee-Jung, Sabuncu, Sinan, Singh, Priya, Ronnebaum, Trey A., Ou, Siyu, Douglas, Justin T., Jackson, Timothy A., Moënne-Loccoz, Pierre, Mure, Minae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694262/
https://www.ncbi.nlm.nih.gov/pubmed/36430446
http://dx.doi.org/10.3390/ijms232213966

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