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Effect of Goreisan, a Japanese Traditional Medicine, on Cortical Spreading Depolarization in Mice
Goreisan, a traditional Japanese Kampo medicine, is often used to treat headaches, including migraines; however, the underlying mechanisms remain unknown. Therefore, we investigated whether chronic treatment with Goreisan affects cortical spreading depolarization (CSD) in migraines. CSD susceptibili...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694318/ https://www.ncbi.nlm.nih.gov/pubmed/36430280 http://dx.doi.org/10.3390/ijms232213803 |
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author | Iba, Chisato Unekawa, Miyuki Izawa, Yoshikane Nakahara, Jin Takizawa, Tsubasa |
author_facet | Iba, Chisato Unekawa, Miyuki Izawa, Yoshikane Nakahara, Jin Takizawa, Tsubasa |
author_sort | Iba, Chisato |
collection | PubMed |
description | Goreisan, a traditional Japanese Kampo medicine, is often used to treat headaches, including migraines; however, the underlying mechanisms remain unknown. Therefore, we investigated whether chronic treatment with Goreisan affects cortical spreading depolarization (CSD) in migraines. CSD susceptibility was assessed in male and female C57BL/6 mice by comparing CSD threshold, propagation velocity, and CSD frequency between animals treated with Goreisan for approximately 3 weeks and the corresponding controls with a potassium-induced CSD model. No significant differences were observed in CSD susceptibility between mice that were chronically treated with Goreisan and the control mice. Additionally, no significant differences were observed in other physiological parameters, including body weight, blood gases, and blood pressure. CSD susceptibility was not affected by chronic treatment with Goreisan, which suggests that the drug treats headaches via mechanisms that do not involve CSD modulation. |
format | Online Article Text |
id | pubmed-9694318 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96943182022-11-26 Effect of Goreisan, a Japanese Traditional Medicine, on Cortical Spreading Depolarization in Mice Iba, Chisato Unekawa, Miyuki Izawa, Yoshikane Nakahara, Jin Takizawa, Tsubasa Int J Mol Sci Communication Goreisan, a traditional Japanese Kampo medicine, is often used to treat headaches, including migraines; however, the underlying mechanisms remain unknown. Therefore, we investigated whether chronic treatment with Goreisan affects cortical spreading depolarization (CSD) in migraines. CSD susceptibility was assessed in male and female C57BL/6 mice by comparing CSD threshold, propagation velocity, and CSD frequency between animals treated with Goreisan for approximately 3 weeks and the corresponding controls with a potassium-induced CSD model. No significant differences were observed in CSD susceptibility between mice that were chronically treated with Goreisan and the control mice. Additionally, no significant differences were observed in other physiological parameters, including body weight, blood gases, and blood pressure. CSD susceptibility was not affected by chronic treatment with Goreisan, which suggests that the drug treats headaches via mechanisms that do not involve CSD modulation. MDPI 2022-11-09 /pmc/articles/PMC9694318/ /pubmed/36430280 http://dx.doi.org/10.3390/ijms232213803 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Iba, Chisato Unekawa, Miyuki Izawa, Yoshikane Nakahara, Jin Takizawa, Tsubasa Effect of Goreisan, a Japanese Traditional Medicine, on Cortical Spreading Depolarization in Mice |
title | Effect of Goreisan, a Japanese Traditional Medicine, on Cortical Spreading Depolarization in Mice |
title_full | Effect of Goreisan, a Japanese Traditional Medicine, on Cortical Spreading Depolarization in Mice |
title_fullStr | Effect of Goreisan, a Japanese Traditional Medicine, on Cortical Spreading Depolarization in Mice |
title_full_unstemmed | Effect of Goreisan, a Japanese Traditional Medicine, on Cortical Spreading Depolarization in Mice |
title_short | Effect of Goreisan, a Japanese Traditional Medicine, on Cortical Spreading Depolarization in Mice |
title_sort | effect of goreisan, a japanese traditional medicine, on cortical spreading depolarization in mice |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694318/ https://www.ncbi.nlm.nih.gov/pubmed/36430280 http://dx.doi.org/10.3390/ijms232213803 |
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