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Effect of Goreisan, a Japanese Traditional Medicine, on Cortical Spreading Depolarization in Mice

Goreisan, a traditional Japanese Kampo medicine, is often used to treat headaches, including migraines; however, the underlying mechanisms remain unknown. Therefore, we investigated whether chronic treatment with Goreisan affects cortical spreading depolarization (CSD) in migraines. CSD susceptibili...

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Detalles Bibliográficos
Autores principales: Iba, Chisato, Unekawa, Miyuki, Izawa, Yoshikane, Nakahara, Jin, Takizawa, Tsubasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694318/
https://www.ncbi.nlm.nih.gov/pubmed/36430280
http://dx.doi.org/10.3390/ijms232213803
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author Iba, Chisato
Unekawa, Miyuki
Izawa, Yoshikane
Nakahara, Jin
Takizawa, Tsubasa
author_facet Iba, Chisato
Unekawa, Miyuki
Izawa, Yoshikane
Nakahara, Jin
Takizawa, Tsubasa
author_sort Iba, Chisato
collection PubMed
description Goreisan, a traditional Japanese Kampo medicine, is often used to treat headaches, including migraines; however, the underlying mechanisms remain unknown. Therefore, we investigated whether chronic treatment with Goreisan affects cortical spreading depolarization (CSD) in migraines. CSD susceptibility was assessed in male and female C57BL/6 mice by comparing CSD threshold, propagation velocity, and CSD frequency between animals treated with Goreisan for approximately 3 weeks and the corresponding controls with a potassium-induced CSD model. No significant differences were observed in CSD susceptibility between mice that were chronically treated with Goreisan and the control mice. Additionally, no significant differences were observed in other physiological parameters, including body weight, blood gases, and blood pressure. CSD susceptibility was not affected by chronic treatment with Goreisan, which suggests that the drug treats headaches via mechanisms that do not involve CSD modulation.
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spelling pubmed-96943182022-11-26 Effect of Goreisan, a Japanese Traditional Medicine, on Cortical Spreading Depolarization in Mice Iba, Chisato Unekawa, Miyuki Izawa, Yoshikane Nakahara, Jin Takizawa, Tsubasa Int J Mol Sci Communication Goreisan, a traditional Japanese Kampo medicine, is often used to treat headaches, including migraines; however, the underlying mechanisms remain unknown. Therefore, we investigated whether chronic treatment with Goreisan affects cortical spreading depolarization (CSD) in migraines. CSD susceptibility was assessed in male and female C57BL/6 mice by comparing CSD threshold, propagation velocity, and CSD frequency between animals treated with Goreisan for approximately 3 weeks and the corresponding controls with a potassium-induced CSD model. No significant differences were observed in CSD susceptibility between mice that were chronically treated with Goreisan and the control mice. Additionally, no significant differences were observed in other physiological parameters, including body weight, blood gases, and blood pressure. CSD susceptibility was not affected by chronic treatment with Goreisan, which suggests that the drug treats headaches via mechanisms that do not involve CSD modulation. MDPI 2022-11-09 /pmc/articles/PMC9694318/ /pubmed/36430280 http://dx.doi.org/10.3390/ijms232213803 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Iba, Chisato
Unekawa, Miyuki
Izawa, Yoshikane
Nakahara, Jin
Takizawa, Tsubasa
Effect of Goreisan, a Japanese Traditional Medicine, on Cortical Spreading Depolarization in Mice
title Effect of Goreisan, a Japanese Traditional Medicine, on Cortical Spreading Depolarization in Mice
title_full Effect of Goreisan, a Japanese Traditional Medicine, on Cortical Spreading Depolarization in Mice
title_fullStr Effect of Goreisan, a Japanese Traditional Medicine, on Cortical Spreading Depolarization in Mice
title_full_unstemmed Effect of Goreisan, a Japanese Traditional Medicine, on Cortical Spreading Depolarization in Mice
title_short Effect of Goreisan, a Japanese Traditional Medicine, on Cortical Spreading Depolarization in Mice
title_sort effect of goreisan, a japanese traditional medicine, on cortical spreading depolarization in mice
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694318/
https://www.ncbi.nlm.nih.gov/pubmed/36430280
http://dx.doi.org/10.3390/ijms232213803
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