Ion-Triggered In Situ Gelling Intranasal Spray of Dronedarone Hydrochloride Nanocarriers: In Vitro Optimization and In Vivo Pharmacokinetic Appraisal

The current study aims to develop niosomal nanocarriers for intranasal delivery of dronedarone hydrochloride to ameliorate its limited bioavailability. Niosomes were prepared by ethanol injection method and optimized using 3² full factorial experimental design. Both Span(®) type (X1) and Span(®): ch...

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Detalles Bibliográficos
Autores principales: Teaima, Mahmoud H., Helal, Doaa A., Alsofany, Jihad M., El-Nabarawi, Mohamed A., Yasser, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694345/
https://www.ncbi.nlm.nih.gov/pubmed/36365223
http://dx.doi.org/10.3390/pharmaceutics14112405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694345/
https://www.ncbi.nlm.nih.gov/pubmed/36365223
http://dx.doi.org/10.3390/pharmaceutics14112405

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