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ATP-Binding Cassette Protein ABCC10 Deficiency Prevents Diet-Induced Obesity but Not Atherosclerosis in Mice

Excess plasma lipid levels are a risk factor for various cardiometabolic disorders. Studies have shown that improving dyslipidemia lowers the progression of these disorders. In this study, we investigated the role of ATP-binding cassette transporter C10 (ABCC10) in regulating lipid metabolism. Our d...

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Autores principales: Otaibi, Abeer Al, Mubarak, Sindiyan Alshaikh, Qarni, Ali Al, Hawwari, Abbas, Bakillah, Ahmed, Iqbal, Jahangir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694421/
https://www.ncbi.nlm.nih.gov/pubmed/36430292
http://dx.doi.org/10.3390/ijms232213813
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author Otaibi, Abeer Al
Mubarak, Sindiyan Alshaikh
Qarni, Ali Al
Hawwari, Abbas
Bakillah, Ahmed
Iqbal, Jahangir
author_facet Otaibi, Abeer Al
Mubarak, Sindiyan Alshaikh
Qarni, Ali Al
Hawwari, Abbas
Bakillah, Ahmed
Iqbal, Jahangir
author_sort Otaibi, Abeer Al
collection PubMed
description Excess plasma lipid levels are a risk factor for various cardiometabolic disorders. Studies have shown that improving dyslipidemia lowers the progression of these disorders. In this study, we investigated the role of ATP-binding cassette transporter C10 (ABCC10) in regulating lipid metabolism. Our data indicate that deletion of the Abcc10 gene in male mice results in lower plasma and intestinal triglycerides by around 38% and 36%, respectively. Furthermore, deletion of ABCC10 ameliorates diet-induced obesity in mice and leads to a better response during insulin and glucose tolerance tests. Unexpectedly, ABCC10 deficiency does not affect triglyceride levels or atherosclerosis in ApoE-deficient mice. In addition, our studies demonstrate low oleate uptake by enterocytes (~25–30%) and less absorption (~37%) of triglycerides in the small intestine of ABCC10 knockout mice. Deletion of the Abcc10 gene also alters several lipid metabolism genes in the intestine, suggesting that ABCC10 regulates dietary fat absorption, which may contribute to diet-induced obesity in mice.
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spelling pubmed-96944212022-11-26 ATP-Binding Cassette Protein ABCC10 Deficiency Prevents Diet-Induced Obesity but Not Atherosclerosis in Mice Otaibi, Abeer Al Mubarak, Sindiyan Alshaikh Qarni, Ali Al Hawwari, Abbas Bakillah, Ahmed Iqbal, Jahangir Int J Mol Sci Article Excess plasma lipid levels are a risk factor for various cardiometabolic disorders. Studies have shown that improving dyslipidemia lowers the progression of these disorders. In this study, we investigated the role of ATP-binding cassette transporter C10 (ABCC10) in regulating lipid metabolism. Our data indicate that deletion of the Abcc10 gene in male mice results in lower plasma and intestinal triglycerides by around 38% and 36%, respectively. Furthermore, deletion of ABCC10 ameliorates diet-induced obesity in mice and leads to a better response during insulin and glucose tolerance tests. Unexpectedly, ABCC10 deficiency does not affect triglyceride levels or atherosclerosis in ApoE-deficient mice. In addition, our studies demonstrate low oleate uptake by enterocytes (~25–30%) and less absorption (~37%) of triglycerides in the small intestine of ABCC10 knockout mice. Deletion of the Abcc10 gene also alters several lipid metabolism genes in the intestine, suggesting that ABCC10 regulates dietary fat absorption, which may contribute to diet-induced obesity in mice. MDPI 2022-11-10 /pmc/articles/PMC9694421/ /pubmed/36430292 http://dx.doi.org/10.3390/ijms232213813 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Otaibi, Abeer Al
Mubarak, Sindiyan Alshaikh
Qarni, Ali Al
Hawwari, Abbas
Bakillah, Ahmed
Iqbal, Jahangir
ATP-Binding Cassette Protein ABCC10 Deficiency Prevents Diet-Induced Obesity but Not Atherosclerosis in Mice
title ATP-Binding Cassette Protein ABCC10 Deficiency Prevents Diet-Induced Obesity but Not Atherosclerosis in Mice
title_full ATP-Binding Cassette Protein ABCC10 Deficiency Prevents Diet-Induced Obesity but Not Atherosclerosis in Mice
title_fullStr ATP-Binding Cassette Protein ABCC10 Deficiency Prevents Diet-Induced Obesity but Not Atherosclerosis in Mice
title_full_unstemmed ATP-Binding Cassette Protein ABCC10 Deficiency Prevents Diet-Induced Obesity but Not Atherosclerosis in Mice
title_short ATP-Binding Cassette Protein ABCC10 Deficiency Prevents Diet-Induced Obesity but Not Atherosclerosis in Mice
title_sort atp-binding cassette protein abcc10 deficiency prevents diet-induced obesity but not atherosclerosis in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694421/
https://www.ncbi.nlm.nih.gov/pubmed/36430292
http://dx.doi.org/10.3390/ijms232213813
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