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Curious Case of Superfitial Spreading Cervical Squamocellular Carcinoma with Adnexal Involvement

Background and Objectives: Cervical squamous cell carcinoma (SCC) usually showed an infiltrative growth pattern into endocervical stroma. In rare cases, SCC spreads superficially as an intraepithelial lesion to proximal uterine segments, and more rarely, involves invasive and more aggressive behavio...

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Autores principales: Dokić, Milan, Milenković, Svetlana, Jovanović, Ljubiša, Milošević, Branislav, Andrić, Luka, Šaponjski, Dušan, Kesić, Vesna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694448/
https://www.ncbi.nlm.nih.gov/pubmed/36422194
http://dx.doi.org/10.3390/medicina58111655
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author Dokić, Milan
Milenković, Svetlana
Jovanović, Ljubiša
Milošević, Branislav
Andrić, Luka
Šaponjski, Dušan
Kesić, Vesna
author_facet Dokić, Milan
Milenković, Svetlana
Jovanović, Ljubiša
Milošević, Branislav
Andrić, Luka
Šaponjski, Dušan
Kesić, Vesna
author_sort Dokić, Milan
collection PubMed
description Background and Objectives: Cervical squamous cell carcinoma (SCC) usually showed an infiltrative growth pattern into endocervical stroma. In rare cases, SCC spreads superficially as an intraepithelial lesion to proximal uterine segments, and more rarely, involves invasive and more aggressive behavior on secondary sites. Materials and Methods: In this study, we present the case of an interesting form of cervical SCC growth and we discuss the possible reasons for that presentation. Results: After clinical examination and repeated histomorphological analysis, we found remarkable cervical epithelial dysplasia (a high-grade squamous intraepithelial lesion—H-SIL). A histopathology report after conization and hysterectomy showed squamocellular carcinoma with microinvasive focuses. Interestingly, squamocellular carcinoma was found in the proximal uterine and adnexal structure, as well as intraepithelial and microinvasive lesions. Conclusions: Our study described a rare presentation of primary cervical SCC with unusual adnexal involvement. This pattern of tumor growth should be especially considered for patients who are proposed for sparing surgical procedures. A detailed and multidisciplinary approach for every patient is very important because unpredictable cases are present. However, they are rare.
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spelling pubmed-96944482022-11-26 Curious Case of Superfitial Spreading Cervical Squamocellular Carcinoma with Adnexal Involvement Dokić, Milan Milenković, Svetlana Jovanović, Ljubiša Milošević, Branislav Andrić, Luka Šaponjski, Dušan Kesić, Vesna Medicina (Kaunas) Case Report Background and Objectives: Cervical squamous cell carcinoma (SCC) usually showed an infiltrative growth pattern into endocervical stroma. In rare cases, SCC spreads superficially as an intraepithelial lesion to proximal uterine segments, and more rarely, involves invasive and more aggressive behavior on secondary sites. Materials and Methods: In this study, we present the case of an interesting form of cervical SCC growth and we discuss the possible reasons for that presentation. Results: After clinical examination and repeated histomorphological analysis, we found remarkable cervical epithelial dysplasia (a high-grade squamous intraepithelial lesion—H-SIL). A histopathology report after conization and hysterectomy showed squamocellular carcinoma with microinvasive focuses. Interestingly, squamocellular carcinoma was found in the proximal uterine and adnexal structure, as well as intraepithelial and microinvasive lesions. Conclusions: Our study described a rare presentation of primary cervical SCC with unusual adnexal involvement. This pattern of tumor growth should be especially considered for patients who are proposed for sparing surgical procedures. A detailed and multidisciplinary approach for every patient is very important because unpredictable cases are present. However, they are rare. MDPI 2022-11-16 /pmc/articles/PMC9694448/ /pubmed/36422194 http://dx.doi.org/10.3390/medicina58111655 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Dokić, Milan
Milenković, Svetlana
Jovanović, Ljubiša
Milošević, Branislav
Andrić, Luka
Šaponjski, Dušan
Kesić, Vesna
Curious Case of Superfitial Spreading Cervical Squamocellular Carcinoma with Adnexal Involvement
title Curious Case of Superfitial Spreading Cervical Squamocellular Carcinoma with Adnexal Involvement
title_full Curious Case of Superfitial Spreading Cervical Squamocellular Carcinoma with Adnexal Involvement
title_fullStr Curious Case of Superfitial Spreading Cervical Squamocellular Carcinoma with Adnexal Involvement
title_full_unstemmed Curious Case of Superfitial Spreading Cervical Squamocellular Carcinoma with Adnexal Involvement
title_short Curious Case of Superfitial Spreading Cervical Squamocellular Carcinoma with Adnexal Involvement
title_sort curious case of superfitial spreading cervical squamocellular carcinoma with adnexal involvement
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694448/
https://www.ncbi.nlm.nih.gov/pubmed/36422194
http://dx.doi.org/10.3390/medicina58111655
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