Cargando…

COVID-19 Mortality in Vaccinated vs. Unvaccinated Liver & Kidney Transplant Recipients: A Single-Center United States Propensity Score Matching Study on Historical Data

Introduction: Existing studies report variable impact of vaccination on Coronavirus Disease (COVID-19) morbidity and mortality in solid organ transplant (SOT) recipients. This study aimed to perform a propensity score matching (PSM) analysis on COVID-19 survival of vaccinated and unvaccinated SOT pa...

Descripción completa

Detalles Bibliográficos
Autores principales: Hardgrave, Hailey, Wells, Allison, Nigh, Joseph, Klutts, Garrett, Krinock, Derek, Osborn, Tamara, Bhusal, Sushma, Rude, Mary K., Burdine, Lyle, Giorgakis, Emmanouil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694459/
https://www.ncbi.nlm.nih.gov/pubmed/36423017
http://dx.doi.org/10.3390/vaccines10111921
_version_ 1784837804902055936
author Hardgrave, Hailey
Wells, Allison
Nigh, Joseph
Klutts, Garrett
Krinock, Derek
Osborn, Tamara
Bhusal, Sushma
Rude, Mary K.
Burdine, Lyle
Giorgakis, Emmanouil
author_facet Hardgrave, Hailey
Wells, Allison
Nigh, Joseph
Klutts, Garrett
Krinock, Derek
Osborn, Tamara
Bhusal, Sushma
Rude, Mary K.
Burdine, Lyle
Giorgakis, Emmanouil
author_sort Hardgrave, Hailey
collection PubMed
description Introduction: Existing studies report variable impact of vaccination on Coronavirus Disease (COVID-19) morbidity and mortality in solid organ transplant (SOT) recipients. This study aimed to perform a propensity score matching (PSM) analysis on COVID-19 survival of vaccinated and unvaccinated SOT patients who contracted the disease at a single US academic transplant center. Methods: All consecutive COVID-19 positive cases on adult liver, kidney or combined liver-kidney recipients were identified and demographics, comorbidities, immunosuppression, COVID-19 treatment and hospitalization status, COVID-19 vaccination status, and early mortality recorded. PSM study was performed on age and sex for completed vaccination status at time of infection, followed by multivariable analysis and survival curve plotting. Results: 144 SOT patients were diagnosed with COVID-19, with 98 unvaccinated. PSM reduced study number to 101. Matched data multivariable analysis for 60-day mortality identified age and post-kidney transplant status to significantly increase 60-day mortality odds (OR 1.22, p < 0.001 and OR 40.93, p < 0.001, respectively). Kaplan–Meier analysis showed inferior post-infection survival in the unvaccinated group [(30 days; vaccinated vs. unvaccinated 97.8% vs. 89.1%, respectively; p = 0.089) (60 days; 97.8% vs. 83.6%, respectively; p = 0.019)]. Conclusions: Matched data survival analysis demonstrated inferior survival in the unvaccinated group, supporting COVID-19 vaccination in SOT recipients.
format Online
Article
Text
id pubmed-9694459
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96944592022-11-26 COVID-19 Mortality in Vaccinated vs. Unvaccinated Liver & Kidney Transplant Recipients: A Single-Center United States Propensity Score Matching Study on Historical Data Hardgrave, Hailey Wells, Allison Nigh, Joseph Klutts, Garrett Krinock, Derek Osborn, Tamara Bhusal, Sushma Rude, Mary K. Burdine, Lyle Giorgakis, Emmanouil Vaccines (Basel) Article Introduction: Existing studies report variable impact of vaccination on Coronavirus Disease (COVID-19) morbidity and mortality in solid organ transplant (SOT) recipients. This study aimed to perform a propensity score matching (PSM) analysis on COVID-19 survival of vaccinated and unvaccinated SOT patients who contracted the disease at a single US academic transplant center. Methods: All consecutive COVID-19 positive cases on adult liver, kidney or combined liver-kidney recipients were identified and demographics, comorbidities, immunosuppression, COVID-19 treatment and hospitalization status, COVID-19 vaccination status, and early mortality recorded. PSM study was performed on age and sex for completed vaccination status at time of infection, followed by multivariable analysis and survival curve plotting. Results: 144 SOT patients were diagnosed with COVID-19, with 98 unvaccinated. PSM reduced study number to 101. Matched data multivariable analysis for 60-day mortality identified age and post-kidney transplant status to significantly increase 60-day mortality odds (OR 1.22, p < 0.001 and OR 40.93, p < 0.001, respectively). Kaplan–Meier analysis showed inferior post-infection survival in the unvaccinated group [(30 days; vaccinated vs. unvaccinated 97.8% vs. 89.1%, respectively; p = 0.089) (60 days; 97.8% vs. 83.6%, respectively; p = 0.019)]. Conclusions: Matched data survival analysis demonstrated inferior survival in the unvaccinated group, supporting COVID-19 vaccination in SOT recipients. MDPI 2022-11-13 /pmc/articles/PMC9694459/ /pubmed/36423017 http://dx.doi.org/10.3390/vaccines10111921 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hardgrave, Hailey
Wells, Allison
Nigh, Joseph
Klutts, Garrett
Krinock, Derek
Osborn, Tamara
Bhusal, Sushma
Rude, Mary K.
Burdine, Lyle
Giorgakis, Emmanouil
COVID-19 Mortality in Vaccinated vs. Unvaccinated Liver & Kidney Transplant Recipients: A Single-Center United States Propensity Score Matching Study on Historical Data
title COVID-19 Mortality in Vaccinated vs. Unvaccinated Liver & Kidney Transplant Recipients: A Single-Center United States Propensity Score Matching Study on Historical Data
title_full COVID-19 Mortality in Vaccinated vs. Unvaccinated Liver & Kidney Transplant Recipients: A Single-Center United States Propensity Score Matching Study on Historical Data
title_fullStr COVID-19 Mortality in Vaccinated vs. Unvaccinated Liver & Kidney Transplant Recipients: A Single-Center United States Propensity Score Matching Study on Historical Data
title_full_unstemmed COVID-19 Mortality in Vaccinated vs. Unvaccinated Liver & Kidney Transplant Recipients: A Single-Center United States Propensity Score Matching Study on Historical Data
title_short COVID-19 Mortality in Vaccinated vs. Unvaccinated Liver & Kidney Transplant Recipients: A Single-Center United States Propensity Score Matching Study on Historical Data
title_sort covid-19 mortality in vaccinated vs. unvaccinated liver & kidney transplant recipients: a single-center united states propensity score matching study on historical data
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694459/
https://www.ncbi.nlm.nih.gov/pubmed/36423017
http://dx.doi.org/10.3390/vaccines10111921
work_keys_str_mv AT hardgravehailey covid19mortalityinvaccinatedvsunvaccinatedliverkidneytransplantrecipientsasinglecenterunitedstatespropensityscorematchingstudyonhistoricaldata
AT wellsallison covid19mortalityinvaccinatedvsunvaccinatedliverkidneytransplantrecipientsasinglecenterunitedstatespropensityscorematchingstudyonhistoricaldata
AT nighjoseph covid19mortalityinvaccinatedvsunvaccinatedliverkidneytransplantrecipientsasinglecenterunitedstatespropensityscorematchingstudyonhistoricaldata
AT kluttsgarrett covid19mortalityinvaccinatedvsunvaccinatedliverkidneytransplantrecipientsasinglecenterunitedstatespropensityscorematchingstudyonhistoricaldata
AT krinockderek covid19mortalityinvaccinatedvsunvaccinatedliverkidneytransplantrecipientsasinglecenterunitedstatespropensityscorematchingstudyonhistoricaldata
AT osborntamara covid19mortalityinvaccinatedvsunvaccinatedliverkidneytransplantrecipientsasinglecenterunitedstatespropensityscorematchingstudyonhistoricaldata
AT bhusalsushma covid19mortalityinvaccinatedvsunvaccinatedliverkidneytransplantrecipientsasinglecenterunitedstatespropensityscorematchingstudyonhistoricaldata
AT rudemaryk covid19mortalityinvaccinatedvsunvaccinatedliverkidneytransplantrecipientsasinglecenterunitedstatespropensityscorematchingstudyonhistoricaldata
AT burdinelyle covid19mortalityinvaccinatedvsunvaccinatedliverkidneytransplantrecipientsasinglecenterunitedstatespropensityscorematchingstudyonhistoricaldata
AT giorgakisemmanouil covid19mortalityinvaccinatedvsunvaccinatedliverkidneytransplantrecipientsasinglecenterunitedstatespropensityscorematchingstudyonhistoricaldata