Cargando…

Artificial intelligence to guide precision anticancer therapy with multitargeted kinase inhibitors

BACKGROUND: Vast amounts of rapidly accumulating biological data related to cancer and a remarkable progress in the field of artificial intelligence (AI) have paved the way for precision oncology. Our recent contribution to this area of research is CancerOmicsNet, an AI-based system to predict the t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Singha, Manali, Pu, Limeng, Stanfield, Brent A., Uche, Ifeanyi K., Rider, Paul J. F., Kousoulas, Konstantin G., Ramanujam, J., Brylinski, Michal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694576/ https://www.ncbi.nlm.nih.gov/pubmed/36434556 http://dx.doi.org/10.1186/s12885-022-10293-0

Ejemplares similares

Unlocking the Potential of Kinase Targets in Cancer: Insights from CancerOmicsNet, an AI-Driven Approach to Drug Response Prediction in Cancer
por: Singha, Manali, et al.
Publicado: (2023)

CancerOmicsNet: a multi-omics network-based approach to anti-cancer drug profiling
por: Pu, Limeng, et al.
Publicado: (2022)

Pocket2Drug: An Encoder-Decoder Deep Neural Network for the Target-Based Drug Design
por: Shi, Wentao, et al.
Publicado: (2022)

GraphSite: Ligand Binding Site Classification with Deep Graph Learning
por: Shi, Wentao, et al.
Publicado: (2022)

An integrated network representation of multiple cancer-specific data for graph-based machine learning
por: Pu, Limeng, et al.
Publicado: (2022)

Utility of a Recombinant HSV-1 Vaccine Vector for Personalized Cancer Vaccines
por: Uche, Ifeanyi Kingsley, et al.
Publicado: (2022)

GraphDTI: A robust deep learning predictor of drug-target interactions from multiple heterogeneous data
por: Liu, Guannan, et al.
Publicado: (2021)

The Effect of Herpes Simplex Virus-Type-1 (HSV-1) Oncolytic Immunotherapy on the Tumor Microenvironment
por: Uche, Ifeanyi Kingsley, et al.
Publicado: (2021)

Augmented drug combination dataset to improve the performance of machine learning models predicting synergistic anticancer effects
por: Liu, Mengmeng, et al.
Publicado: (2023)

Identification and Visualization of Functionally Important Domains and Residues in Herpes Simplex Virus Glycoprotein K(gK) Using a Combination of Phylogenetics and Protein Modeling
por: Rider, Paul J. F., et al.
Publicado: (2019)

Rational Design of Live-Attenuated Vaccines against Herpes Simplex Viruses
por: Stanfield, Brent A., et al.
Publicado: (2021)

Large-scale computational drug repositioning to find treatments for rare diseases
por: Govindaraj, Rajiv Gandhi, et al.
Publicado: (2018)

Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents
por: Ververis, Katherine, et al.
Publicado: (2013)

Novel Oncolytic Herpes Simplex Virus 1 VC2 Promotes Long-Lasting, Systemic Anti-melanoma Tumor Immune Responses and Increased Survival in an Immunocompetent B16F10-Derived Mouse Melanoma Model
por: Uche, Ifeanyi Kingsley, et al.
Publicado: (2021)

45724 VC2 Oncolytic Virotherapy Induces Robust Systemic Anti-Tumor Immunity and Increases Survival in an Immunocompetent B16F10-derived Mouse Melanoma Model
por: Uche, Ifeanyi Kingsley, et al.
Publicado: (2021)

Multitarget Anticancer Agents Based on Histone Deacetylase and Protein Kinase CK2 Inhibitors
por: Martínez, Regina, et al.
Publicado: (2020)

Aryl Urea Based Scaffolds for Multitarget Drug Discovery in Anticancer Immunotherapies
por: Martín-Beltrán, Celia, et al.
Publicado: (2021)

Synthesis and Biological Evaluation of Small Molecules as Potential Anticancer Multitarget Agents
por: Pla-López, Alberto, et al.
Publicado: (2022)

Editorial: Artificial Intelligence for Precision Medicine
por: Deng, Jun, et al.
Publicado: (2022)

Artificial intelligence for the discovery of novel antimicrobial agents for emerging infectious diseases
por: Bess, Adam, et al.
Publicado: (2022)

Single dose of Glycoprotein K (gK)-deleted HSV-1 live-attenuated virus protects mice against lethal vaginal challenge with HSV-1 and HSV-2 and induces lasting T cell memory immune responses
por: Iyer, Arun V, et al.
Publicado: (2013)

eToxPred: a machine learning-based approach to estimate the toxicity of drug candidates
por: Pu, Limeng, et al.
Publicado: (2019)

DeepDrug3D: Classification of ligand-binding pockets in proteins with a convolutional neural network
por: Pu, Limeng, et al.
Publicado: (2019)

Intramuscular vaccination of mice with the human herpes simplex virus type-1(HSV-1) VC2 vaccine, but not its parental strain HSV-1(F) confers full protection against lethal ocular HSV-1 (McKrae) pathogenesis
por: Naidu, Shan K., et al.
Publicado: (2020)

Precision immunoprofiling by image analysis and artificial intelligence
por: Koelzer, Viktor H., et al.
Publicado: (2018)

Artificial intelligence for precision medicine in neurodevelopmental disorders
por: Uddin, Mohammed, et al.
Publicado: (2019)

Opportunities for Artificial Intelligence in Advancing Precision Medicine
por: Filipp, Fabian V.
Publicado: (2019)

Artificial intelligence for the next generation of precision oncology
por: Ballester, Pedro J., et al.
Publicado: (2021)

Multiomics, Artificial Intelligence and Precision Medicine in Perinatology
por: Pammi, Mohan, et al.
Publicado: (2023)

Precision Medicine Approaches with Metabolomics and Artificial Intelligence
por: Barberis, Elettra, et al.
Publicado: (2022)

Extended Arm of Precision in Prosthodontics: Artificial Intelligence
por: Singi, Shriya R, et al.
Publicado: (2022)

Multitargeting activity of miR-24 inhibits long-term melatonin anticancer effects
por: Mori, Federica, et al.
Publicado: (2016)

Unveiling a New Selenocyanate as a Multitarget Candidate with Anticancer, Antileishmanial and Antibacterial Potential
por: Ramos-Inza, Sandra, et al.
Publicado: (2022)

Herpes Simplex Virus 1 UL37 Protein Tyrosine Residues Conserved among All Alphaherpesviruses Are Required for Interactions with Glycoprotein K, Cytoplasmic Virion Envelopment, and Infectious Virus Production
por: Chouljenko, Dmitry V., et al.
Publicado: (2016)

Artificial intelligence in precision health: from concept to applications
por: Barh, Debmalya
Publicado: (2020)

Artificial intelligence for drug development, precision medicine, and healthcare
por: Chang, Mark
Publicado: (2020)

Radiomics with artificial intelligence for precision medicine in radiation therapy
por: Arimura, Hidetaka, et al.
Publicado: (2019)

Artificial intelligence for precision oncology: beyond patient stratification
por: Azuaje, Francisco
Publicado: (2019)

Artificial intelligence, radiology, precision medicine, and personalized medicine
por: Leite, Claudia da Costa
Publicado: (2019)

On the Role of Artificial Intelligence in Genomics to Enhance Precision Medicine
por: Álvarez-Machancoses, Óscar, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_3bo58d9r83ghgsul7llo9irtvq