Discovery of a 2′-Fluoro,2′-Bromouridine Phosphoramidate Prodrug Exhibiting Anti-Yellow Fever Virus Activity in Culture and in Mice

Yellow fever virus (YFV) is a potentially lethal, zoonotic, blood-borne flavivirus transmitted to humans and non-human primates by mosquitoes. Owing to multiple deadly epidemics, the WHO classifies YFV as a “high impact, high threat disease” with resurgent epidemic potential. At present, there are n...

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Detalles Bibliográficos
Autores principales: LeCher, Julia C., Zandi, Keivan, Costa, Vivian Vasconcelos, Amblard, Franck, Tao, Sijia, Patel, Dharmeshkumar, Lee, Sujin, da Silva Santos, Felipe Rocha, Goncalves, Matheus Rodrigues, Queroz-Junior, Celso Martins, Marim, Fernanda Martins, Musall, Katie, Goh, Shu Ling, McBrayer, Tamara, Downs-Bowen, Jessica, De, Ramyani, Azadi, Niloufar, Kohler, James, Teixeira, Mauro Martins, Schinazi, Raymond F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694579/
https://www.ncbi.nlm.nih.gov/pubmed/36363688
http://dx.doi.org/10.3390/microorganisms10112098

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