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Concomitant Intra-Aortic Balloon Pumping Significantly Reduces Left Ventricular Pressure during Central Veno-Arterial Extracorporeal Membrane Oxygenation—Results from a Large Animal Model
(1) Introduction: Simultaneous ECMO and IABP therapy is frequently used. Haemodynamic changes responsible for the success of the concomitant mechanical circulatory support system approach are rarely investigated. In a large-animal model, we analysed haemodynamic parameters before and during ECMO the...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694613/ https://www.ncbi.nlm.nih.gov/pubmed/36430994 http://dx.doi.org/10.3390/life12111859 |
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author | Djordjevic, Ilija Liakopoulos, Oliver Elskamp, Mara Maier-Trauth, Johanna Gerfer, Stephen Mühlbauer, Thomas Slottosch, Ingo Kuhn, Elmar Sabashnikov, Anton Rademann, Pia Maul, Alexandra Paunel-Görgülü, Adnana Wahlers, Thorsten Deppe, Antje Christin |
author_facet | Djordjevic, Ilija Liakopoulos, Oliver Elskamp, Mara Maier-Trauth, Johanna Gerfer, Stephen Mühlbauer, Thomas Slottosch, Ingo Kuhn, Elmar Sabashnikov, Anton Rademann, Pia Maul, Alexandra Paunel-Görgülü, Adnana Wahlers, Thorsten Deppe, Antje Christin |
author_sort | Djordjevic, Ilija |
collection | PubMed |
description | (1) Introduction: Simultaneous ECMO and IABP therapy is frequently used. Haemodynamic changes responsible for the success of the concomitant mechanical circulatory support system approach are rarely investigated. In a large-animal model, we analysed haemodynamic parameters before and during ECMO therapy, comparing central and peripheral ECMO circulation with and without simultaneous IABP support. (2) Methods: Thirty-three female pigs were divided into five groups: (1) SHAM, (2) (peripheral)ECMO(–)IABP, (3) (p)ECMO(+)IABP, (4) (central)ECMO(–)IABP, and (5) (c)ECMO(+)IABP. Pigs were cannulated in accordance with the group and supported with ECMO (±IABP) for 10 h. Systemic haemodynamics, cardiac index (CI), and coronary and carotid artery blood flow were determined before, directly after, and at five and ten hours on extracorporeal support. Systemic inflammation (IL-6; IL-10; TNFα; IFNγ), immune response (NETs; cf-DNA), and endothelial injury (ET-1) were also measured. (3) Results: IABP support during antegrade ECMO circulation led to a significant reduction of left ventricular pressure in comparison to retrograde flow in (p)ECMO(–)IABP and (p)ECMO(+)IABP. Blood flow in the left anterior coronary and carotid artery was not affected by extracorporeal circulation. (4) Conclusions: Concomitant central ECMO and IABP therapy leads to significant reduction of intracavitary cardiac pressure, reduces cardiac work, and might therefore contribute to improved recovery in ECMO patients. |
format | Online Article Text |
id | pubmed-9694613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96946132022-11-26 Concomitant Intra-Aortic Balloon Pumping Significantly Reduces Left Ventricular Pressure during Central Veno-Arterial Extracorporeal Membrane Oxygenation—Results from a Large Animal Model Djordjevic, Ilija Liakopoulos, Oliver Elskamp, Mara Maier-Trauth, Johanna Gerfer, Stephen Mühlbauer, Thomas Slottosch, Ingo Kuhn, Elmar Sabashnikov, Anton Rademann, Pia Maul, Alexandra Paunel-Görgülü, Adnana Wahlers, Thorsten Deppe, Antje Christin Life (Basel) Article (1) Introduction: Simultaneous ECMO and IABP therapy is frequently used. Haemodynamic changes responsible for the success of the concomitant mechanical circulatory support system approach are rarely investigated. In a large-animal model, we analysed haemodynamic parameters before and during ECMO therapy, comparing central and peripheral ECMO circulation with and without simultaneous IABP support. (2) Methods: Thirty-three female pigs were divided into five groups: (1) SHAM, (2) (peripheral)ECMO(–)IABP, (3) (p)ECMO(+)IABP, (4) (central)ECMO(–)IABP, and (5) (c)ECMO(+)IABP. Pigs were cannulated in accordance with the group and supported with ECMO (±IABP) for 10 h. Systemic haemodynamics, cardiac index (CI), and coronary and carotid artery blood flow were determined before, directly after, and at five and ten hours on extracorporeal support. Systemic inflammation (IL-6; IL-10; TNFα; IFNγ), immune response (NETs; cf-DNA), and endothelial injury (ET-1) were also measured. (3) Results: IABP support during antegrade ECMO circulation led to a significant reduction of left ventricular pressure in comparison to retrograde flow in (p)ECMO(–)IABP and (p)ECMO(+)IABP. Blood flow in the left anterior coronary and carotid artery was not affected by extracorporeal circulation. (4) Conclusions: Concomitant central ECMO and IABP therapy leads to significant reduction of intracavitary cardiac pressure, reduces cardiac work, and might therefore contribute to improved recovery in ECMO patients. MDPI 2022-11-12 /pmc/articles/PMC9694613/ /pubmed/36430994 http://dx.doi.org/10.3390/life12111859 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Djordjevic, Ilija Liakopoulos, Oliver Elskamp, Mara Maier-Trauth, Johanna Gerfer, Stephen Mühlbauer, Thomas Slottosch, Ingo Kuhn, Elmar Sabashnikov, Anton Rademann, Pia Maul, Alexandra Paunel-Görgülü, Adnana Wahlers, Thorsten Deppe, Antje Christin Concomitant Intra-Aortic Balloon Pumping Significantly Reduces Left Ventricular Pressure during Central Veno-Arterial Extracorporeal Membrane Oxygenation—Results from a Large Animal Model |
title | Concomitant Intra-Aortic Balloon Pumping Significantly Reduces Left Ventricular Pressure during Central Veno-Arterial Extracorporeal Membrane Oxygenation—Results from a Large Animal Model |
title_full | Concomitant Intra-Aortic Balloon Pumping Significantly Reduces Left Ventricular Pressure during Central Veno-Arterial Extracorporeal Membrane Oxygenation—Results from a Large Animal Model |
title_fullStr | Concomitant Intra-Aortic Balloon Pumping Significantly Reduces Left Ventricular Pressure during Central Veno-Arterial Extracorporeal Membrane Oxygenation—Results from a Large Animal Model |
title_full_unstemmed | Concomitant Intra-Aortic Balloon Pumping Significantly Reduces Left Ventricular Pressure during Central Veno-Arterial Extracorporeal Membrane Oxygenation—Results from a Large Animal Model |
title_short | Concomitant Intra-Aortic Balloon Pumping Significantly Reduces Left Ventricular Pressure during Central Veno-Arterial Extracorporeal Membrane Oxygenation—Results from a Large Animal Model |
title_sort | concomitant intra-aortic balloon pumping significantly reduces left ventricular pressure during central veno-arterial extracorporeal membrane oxygenation—results from a large animal model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694613/ https://www.ncbi.nlm.nih.gov/pubmed/36430994 http://dx.doi.org/10.3390/life12111859 |
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