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Laboratory Indicators for Identifying Hand, Foot, and Mouth Disease Severity: A Systematic Review and Meta-Analysis

Objective: The purpose of this study is to study laboratory indicators for the identification of hand, foot, and mouth disease (HFMD) severity. Methods: We searched PubMed, Embase, and the Web of Science for literature that was published before May 2022. The main results are presented as forest plot...

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Autores principales: Xie, Yaqi, Hu, Quanman, Jiang, Wenjie, Ji, Wangquan, Chen, Shuaiyin, Jin, Yuefei, Duan, Guangcai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694715/
https://www.ncbi.nlm.nih.gov/pubmed/36366337
http://dx.doi.org/10.3390/vaccines10111829
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author Xie, Yaqi
Hu, Quanman
Jiang, Wenjie
Ji, Wangquan
Chen, Shuaiyin
Jin, Yuefei
Duan, Guangcai
author_facet Xie, Yaqi
Hu, Quanman
Jiang, Wenjie
Ji, Wangquan
Chen, Shuaiyin
Jin, Yuefei
Duan, Guangcai
author_sort Xie, Yaqi
collection PubMed
description Objective: The purpose of this study is to study laboratory indicators for the identification of hand, foot, and mouth disease (HFMD) severity. Methods: We searched PubMed, Embase, and the Web of Science for literature that was published before May 2022. The main results are presented as forest plots. Subgroup analyses, sensitivity analyses, and publication bias were also performed. Results: Our study indicated that white blood cells (WBC) (95%CI: 0.205–0.778), blood glucose (95%CI: 0.505–0.778), lymphocytes (95%CI: 0.072–0.239), creatinine (95%CI: 0.024–0.228), interleukin (IL)-2 (95%CI: 0.192–1.642), IL-6 (95%CI: 0.289–0.776), IL-8 (95%CI: 0.499–0.867), IL-10 (95%CI: 0.226–0.930), interferon-γ (IFN-γ) (95%CI: 0.193–2.584), tumor necrosis factor-α (TNF-α) (95%CI: 1.078–2.715), and creatine kinase MB isoenzyme (CK-MB) (95%CI: 0.571–1.459) were associated with an increased risk of HFMD severity, and the results of the sensitivity analysis of these indicators were stable and free of publication bias. Conclusions: Our results suggest that various deleterious immune and metabolic changes can increase the risk of HFMD severity, which can provide a basis for predicting the prognosis and useful evidence for clinicians to manage patients efficiently.
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spelling pubmed-96947152022-11-26 Laboratory Indicators for Identifying Hand, Foot, and Mouth Disease Severity: A Systematic Review and Meta-Analysis Xie, Yaqi Hu, Quanman Jiang, Wenjie Ji, Wangquan Chen, Shuaiyin Jin, Yuefei Duan, Guangcai Vaccines (Basel) Review Objective: The purpose of this study is to study laboratory indicators for the identification of hand, foot, and mouth disease (HFMD) severity. Methods: We searched PubMed, Embase, and the Web of Science for literature that was published before May 2022. The main results are presented as forest plots. Subgroup analyses, sensitivity analyses, and publication bias were also performed. Results: Our study indicated that white blood cells (WBC) (95%CI: 0.205–0.778), blood glucose (95%CI: 0.505–0.778), lymphocytes (95%CI: 0.072–0.239), creatinine (95%CI: 0.024–0.228), interleukin (IL)-2 (95%CI: 0.192–1.642), IL-6 (95%CI: 0.289–0.776), IL-8 (95%CI: 0.499–0.867), IL-10 (95%CI: 0.226–0.930), interferon-γ (IFN-γ) (95%CI: 0.193–2.584), tumor necrosis factor-α (TNF-α) (95%CI: 1.078–2.715), and creatine kinase MB isoenzyme (CK-MB) (95%CI: 0.571–1.459) were associated with an increased risk of HFMD severity, and the results of the sensitivity analysis of these indicators were stable and free of publication bias. Conclusions: Our results suggest that various deleterious immune and metabolic changes can increase the risk of HFMD severity, which can provide a basis for predicting the prognosis and useful evidence for clinicians to manage patients efficiently. MDPI 2022-10-29 /pmc/articles/PMC9694715/ /pubmed/36366337 http://dx.doi.org/10.3390/vaccines10111829 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Xie, Yaqi
Hu, Quanman
Jiang, Wenjie
Ji, Wangquan
Chen, Shuaiyin
Jin, Yuefei
Duan, Guangcai
Laboratory Indicators for Identifying Hand, Foot, and Mouth Disease Severity: A Systematic Review and Meta-Analysis
title Laboratory Indicators for Identifying Hand, Foot, and Mouth Disease Severity: A Systematic Review and Meta-Analysis
title_full Laboratory Indicators for Identifying Hand, Foot, and Mouth Disease Severity: A Systematic Review and Meta-Analysis
title_fullStr Laboratory Indicators for Identifying Hand, Foot, and Mouth Disease Severity: A Systematic Review and Meta-Analysis
title_full_unstemmed Laboratory Indicators for Identifying Hand, Foot, and Mouth Disease Severity: A Systematic Review and Meta-Analysis
title_short Laboratory Indicators for Identifying Hand, Foot, and Mouth Disease Severity: A Systematic Review and Meta-Analysis
title_sort laboratory indicators for identifying hand, foot, and mouth disease severity: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694715/
https://www.ncbi.nlm.nih.gov/pubmed/36366337
http://dx.doi.org/10.3390/vaccines10111829
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