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Modern imaging techniques for monitoring patients with multiple myeloma

Bone disease is a serious problem for many patients, often causing pathological bone fractures. A spinal collapse is a condition that affects the quality of life. It is the most frequent feature of multiple myeloma (MM), used in establishing the diagnosis and the need to start treatment. Because of...

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Autores principales: Pop, Vlad Stefan, Tomoaia, Gheorghe, Parvu, Andrada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iuliu Hatieganu University of Medicine and Pharmacy 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694753/
https://www.ncbi.nlm.nih.gov/pubmed/36506611
http://dx.doi.org/10.15386/mpr-2215
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author Pop, Vlad Stefan
Tomoaia, Gheorghe
Parvu, Andrada
author_facet Pop, Vlad Stefan
Tomoaia, Gheorghe
Parvu, Andrada
author_sort Pop, Vlad Stefan
collection PubMed
description Bone disease is a serious problem for many patients, often causing pathological bone fractures. A spinal collapse is a condition that affects the quality of life. It is the most frequent feature of multiple myeloma (MM), used in establishing the diagnosis and the need to start treatment. Because of these complications, imaging plays a vital role in the diagnosis and workup of myeloma patients. For many years, conventional radiography has been considered the gold standard for detecting bone lesions. The main reasons are the wide availability, low cost, the relatively low radiation dose and the ability of this imaging method to cover the entire bone system. Because of its incapacity to evaluate the response to therapy, more sophisticated techniques such as whole-body low-dose computed tomography (WBLDCT), whole-body magnetic resonance imaging, and 18F-fluorodeoxyglucose–positron emission tomography/computed tomography (PET/CT) are used. In this review, some of the advantages, indications and applications of the three techniques in managing patients with MM will be discussed. The European Myeloma Network guidelines have recommended WBLDCT as the imaging modality of choice for the initial assessment of MM-related lytic bone lesions. Magnetic resonance imaging is the gold-standard imaging modality for the detection of bone marrow involvement. One of the modern imaging methods and PET/CT can provide valuable prognostic data and is the preferred technique for assessing response to therapy.
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spelling pubmed-96947532022-12-08 Modern imaging techniques for monitoring patients with multiple myeloma Pop, Vlad Stefan Tomoaia, Gheorghe Parvu, Andrada Med Pharm Rep Review Bone disease is a serious problem for many patients, often causing pathological bone fractures. A spinal collapse is a condition that affects the quality of life. It is the most frequent feature of multiple myeloma (MM), used in establishing the diagnosis and the need to start treatment. Because of these complications, imaging plays a vital role in the diagnosis and workup of myeloma patients. For many years, conventional radiography has been considered the gold standard for detecting bone lesions. The main reasons are the wide availability, low cost, the relatively low radiation dose and the ability of this imaging method to cover the entire bone system. Because of its incapacity to evaluate the response to therapy, more sophisticated techniques such as whole-body low-dose computed tomography (WBLDCT), whole-body magnetic resonance imaging, and 18F-fluorodeoxyglucose–positron emission tomography/computed tomography (PET/CT) are used. In this review, some of the advantages, indications and applications of the three techniques in managing patients with MM will be discussed. The European Myeloma Network guidelines have recommended WBLDCT as the imaging modality of choice for the initial assessment of MM-related lytic bone lesions. Magnetic resonance imaging is the gold-standard imaging modality for the detection of bone marrow involvement. One of the modern imaging methods and PET/CT can provide valuable prognostic data and is the preferred technique for assessing response to therapy. Iuliu Hatieganu University of Medicine and Pharmacy 2022-10 2022-10-27 /pmc/articles/PMC9694753/ /pubmed/36506611 http://dx.doi.org/10.15386/mpr-2215 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License https://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Review
Pop, Vlad Stefan
Tomoaia, Gheorghe
Parvu, Andrada
Modern imaging techniques for monitoring patients with multiple myeloma
title Modern imaging techniques for monitoring patients with multiple myeloma
title_full Modern imaging techniques for monitoring patients with multiple myeloma
title_fullStr Modern imaging techniques for monitoring patients with multiple myeloma
title_full_unstemmed Modern imaging techniques for monitoring patients with multiple myeloma
title_short Modern imaging techniques for monitoring patients with multiple myeloma
title_sort modern imaging techniques for monitoring patients with multiple myeloma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694753/
https://www.ncbi.nlm.nih.gov/pubmed/36506611
http://dx.doi.org/10.15386/mpr-2215
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