Cargando…

Chromosomally Unstable Gastric Cancers Overexpressing Claudin-6 Disclose Cross-Talk between HNF1A and HNF4A, and Upregulated Cholesterol Metabolism

(1) Abnormally increased expression of claudin-6 in gastric cancer is considered a prognostic marker of the chromosomal unstable molecular subtype. However, a detailed molecular profile analysis of differentially expressed genes and affected pathways associated with claudin-6 increased (Cldn6(high))...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dwivedi, Sanyog, Hernández-Montes, Georgina, Montaño, Luis Felipe, Rendón-Huerta, Erika Patricia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694805/ https://www.ncbi.nlm.nih.gov/pubmed/36430456 http://dx.doi.org/10.3390/ijms232213977

Ejemplares similares

Species-Specific Differences in the Expression of the HNF1A, HNF1B and HNF4A Genes
por: Harries, Lorna W., et al.
Publicado: (2009)

Functional inhibition of Oct leads to HNF4α upregulation
por: Vollmar, Johanna, et al.
Publicado: (2021)

Inhibitory effects of HNF4α on migration/maltransformation of hepatic progenitors: HNF4α-overexpressing hepatic progenitors for liver repopulation
por: Wang, Ping, et al.
Publicado: (2017)

Disruption of Tumor Suppressors HNF4α/HNF1α Causes Tumorigenesis in Liver
por: Teeli, Aamir Salam, et al.
Publicado: (2021)

HNF4 and HNF1 as well as a panel of hepatic functions are extinguished and reexpressed in parallel in chromosomally reduced rat hepatoma-human fibroblast hybrids
Publicado: (1993)

Epistasis of Transcriptomes Reveals Synergism between Transcriptional Activators Hnf1α and Hnf4α
por: Boj, Sylvia F., et al.
Publicado: (2010)

Structural insights into the HNF4 biology
por: Beinsteiner, Brice, et al.
Publicado: (2023)

Assessment of the HNF1B Score as a Tool to Select Patients for HNF1B Genetic Testing
por: Clissold, Rhian, et al.
Publicado: (2015)

Differential regulation of serum microRNA expression by HNF1β and HNF1α transcription factors
por: Fendler, Wojciech, et al.
Publicado: (2016)

An Atypical HNF4A Mutation Which Does Not Conform to the Classic Presentation of HNF4A-MODY
por: Spiro, Andrew J., et al.
Publicado: (2018)

Crystallization of hepatocyte nuclear factor 4α (HNF4α) in complex with the HNF1α promoter element
por: Lu, Peng, et al.
Publicado: (2008)

HNF4alpha and HNF1alpha Dysfunction as a Molecular Rational for Cyclosporine Induced Posttransplantation Diabetes Mellitus
por: Borlak, Jürgen, et al.
Publicado: (2009)

CD38 and Regulation of the Immune Response Cells in Cancer
por: Dwivedi, Sanyog, et al.
Publicado: (2021)

The Roles of Long Noncoding RNAs HNF1α-AS1 and HNF4α-AS1 in Drug Metabolism and Human Diseases
por: Chen, Liming, et al.
Publicado: (2020)

Reduced penetrance of MODY-associated HNF1A/HNF4A variants but not GCK variants in clinically unselected cohorts
por: Mirshahi, Uyenlinh L, et al.
Publicado: (2022)

LncRNA Hnf4αos exacerbates liver ischemia/reperfusion injury in mice via Hnf4αos/Hnf4α duplex-mediated PGC1α suppression
por: Wang, Chaoqun, et al.
Publicado: (2022)

Sigma 1 Receptor Is Overexpressed in Hepatocellular Adenoma: Involvement of ERα and HNF1α
por: Villemain, Laure, et al.
Publicado: (2020)

A Comprehensive Analysis of Hungarian MODY Patients—Part I: Gene Panel Sequencing Reveals Pathogenic Mutations in HNF1A, HNF1B, HNF4A, ABCC8 and INS Genes
por: Gaál, Zsolt, et al.
Publicado: (2021)

Functional Targets of the Monogenic Diabetes Transcription Factors HNF-1α and HNF-4α Are Highly Conserved Between Mice and Humans
por: Boj, Sylvia F., et al.
Publicado: (2009)

Liver fat storage is controlled by HNF4α through induction of lipophagy and is reversed by a potent HNF4α agonist
por: Lee, Seung-Hee, et al.
Publicado: (2021)

In Silico Docking of HNF-1a Receptor Ligands
por: Sridhar, Gumpeny Ramachandra, et al.
Publicado: (2012)

HNF4A modulates glucocorticoid action in the liver
por: Hunter, A. Louise, et al.
Publicado: (2022)

Structural properties of the HNF-1A transactivation domain
por: Kind, Laura, et al.
Publicado: (2023)

The protein architecture and allosteric landscape of HNF4α
por: Rastinejad, Fraydoon
Publicado: (2023)

HNF1β Diabetes or Maturity-Onset Diabetes of the Young Type 5 With Rare HNF1β Mutation: A Case Report
por: Haynes, Autumn L., et al.
Publicado: (2019)

An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function
por: Cujba, Ana-Maria, et al.
Publicado: (2022)

A potent HNF4α agonist reveals that HNF4α controls genes important in inflammatory bowel disease and Paneth cells
por: Lee, Seung-Hee, et al.
Publicado: (2022)

GSK-3β mediates the effects of HNF-1β overexpression in ovarian clear cell carcinoma
por: Kawahara, Naoki, et al.
Publicado: (2020)

Double Heterozygous Mutations Involving Both HNF1A/MODY3 and HNF4A/MODY1 Genes: A case report
por: Forlani, Gabriele, et al.
Publicado: (2010)

Impact of Nucleotide Mutations at the HNF3- and HNF4-Binding Sites in Enhancer 1 on Viral Replication in Patients with Chronic Hepatitis B Virus Infection
por: Cho, Eun-young, et al.
Publicado: (2013)

The HNF1α-regulated lncRNA HNF1A-AS1 reverses the malignancy of hepatocellular carcinoma by enhancing the phosphatase activity of SHP-1
por: Ding, Chen-Hong, et al.
Publicado: (2018)

Saikosaponin C exerts anti-HBV effects by attenuating HNF1α and HNF4α expression to suppress HBV pgRNA synthesis
por: Pan, Yanchao, et al.
Publicado: (2019)

Mir214-3p and Hnf4a/Hnf4α reciprocally regulate Ulk1 expression and autophagy in nonalcoholic hepatic steatosis
por: Lee, Da-Hye, et al.
Publicado: (2020)

Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation
por: Wang, Chengcheng, et al.
Publicado: (2020)

Integrated bioinformatic analysis of HNF1A in human cancers
por: Zhang, Enfan, et al.
Publicado: (2021)

HNF1A Mutations and Beta Cell Dysfunction in Diabetes
por: Miyachi, Yasutaka, et al.
Publicado: (2022)

Variants influencing age at diagnosis of HNF1A-MODY
por: Ludwig-Słomczyńska, Agnieszka H., et al.
Publicado: (2022)

In vivo Environment Swiftly Restricts Human Pancreatic Progenitors Toward Mono-Hormonal Identity via a HNF1A/HNF4A Mechanism
por: Legøy, Thomas Aga, et al.
Publicado: (2020)

Neddylation inhibitor MLN4924 has anti‐HBV activity via modulating the ERK‐HNF1α‐C/EBPα‐HNF4α axis
por: Xie, Mingjie, et al.
Publicado: (2020)

Co-encapsulation of HNF4α overexpressing UMSCs and human primary hepatocytes ameliorates mouse acute liver failure
por: Kong, Defu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_42tq8bpb7ikv42nvjfsp1kpu08