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Host genetic control on rumen microbiota and its impact on dairy traits in sheep

BACKGROUND: Milk yield and fine composition in sheep depend on the volatile and long-chain fatty acids, microbial proteins, vitamins produced through feedstuff digestion by the rumen microbiota. In cattle, the host genome has been shown to have a low to moderate genetic control on rumen microbiota a...

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Autores principales: Martinez Boggio, Guillermo, Meynadier, Annabelle, Buitenhuis, Albert Johannes, Marie-Etancelin, Christel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694848/
https://www.ncbi.nlm.nih.gov/pubmed/36434501
http://dx.doi.org/10.1186/s12711-022-00769-9
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author Martinez Boggio, Guillermo
Meynadier, Annabelle
Buitenhuis, Albert Johannes
Marie-Etancelin, Christel
author_facet Martinez Boggio, Guillermo
Meynadier, Annabelle
Buitenhuis, Albert Johannes
Marie-Etancelin, Christel
author_sort Martinez Boggio, Guillermo
collection PubMed
description BACKGROUND: Milk yield and fine composition in sheep depend on the volatile and long-chain fatty acids, microbial proteins, vitamins produced through feedstuff digestion by the rumen microbiota. In cattle, the host genome has been shown to have a low to moderate genetic control on rumen microbiota abundance but a high control on dairy traits with heritabilities higher than 0.30. There is little information on the genetic correlations and quantitative trait loci (QTL) that simultaneously affect rumen microbiota abundance and dairy traits in ruminants, especially in sheep. Thus, our aim was to quantify the effect of the host genetics on rumen bacterial abundance and the genetic correlations between rumen bacterial abundance and several dairy traits, and to identify QTL that are associated with both rumen bacterial abundance and milk traits. RESULTS: Our results in Lacaune sheep show that the heritability of rumen bacterial abundance ranges from 0 to 0.29 and that the heritability of 306 operational taxonomic units (OTU) is significantly different from 0. Of these 306 OTU, 96 that belong mainly to the Prevotellaceae, Lachnospiraceae and Ruminococcaceae bacterial families show strong genetic correlations with milk fatty acids and proteins (absolute values ranging from 0.33 to 0.99). Genome-wide association studies revealed a QTL for alpha-lactalbumin concentration in milk on Ovis aries chromosome (OAR) 11, and six QTL for rumen bacterial abundances i.e., for two OTU belonging to the genera Prevotella (OAR3 and 5), Rikeneleaceae_RC9_gut_group (OAR5), Ruminococcus (OAR5), an unknown genus of order Clostridia UCG-014 (OAR10), and CAG-352 (OAR11). None of these detected regions are simultaneously associated with rumen bacterial abundance and dairy traits, but the bacterial families Prevotellaceae, Lachnospiraceae and F082 show colocalized signals on OAR3, 5, 15 and 26. CONCLUSIONS: In Lacaune dairy sheep, rumen microbiota abundance is partially controlled by the host genetics and is poorly genetically linked with milk protein and fatty acid compositions, and three main bacterial families, Prevotellaceae, Lachnospiraceae and F082, show specific associations with OAR3, 5, 15 and 26. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12711-022-00769-9.
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spelling pubmed-96948482022-11-26 Host genetic control on rumen microbiota and its impact on dairy traits in sheep Martinez Boggio, Guillermo Meynadier, Annabelle Buitenhuis, Albert Johannes Marie-Etancelin, Christel Genet Sel Evol Research Article BACKGROUND: Milk yield and fine composition in sheep depend on the volatile and long-chain fatty acids, microbial proteins, vitamins produced through feedstuff digestion by the rumen microbiota. In cattle, the host genome has been shown to have a low to moderate genetic control on rumen microbiota abundance but a high control on dairy traits with heritabilities higher than 0.30. There is little information on the genetic correlations and quantitative trait loci (QTL) that simultaneously affect rumen microbiota abundance and dairy traits in ruminants, especially in sheep. Thus, our aim was to quantify the effect of the host genetics on rumen bacterial abundance and the genetic correlations between rumen bacterial abundance and several dairy traits, and to identify QTL that are associated with both rumen bacterial abundance and milk traits. RESULTS: Our results in Lacaune sheep show that the heritability of rumen bacterial abundance ranges from 0 to 0.29 and that the heritability of 306 operational taxonomic units (OTU) is significantly different from 0. Of these 306 OTU, 96 that belong mainly to the Prevotellaceae, Lachnospiraceae and Ruminococcaceae bacterial families show strong genetic correlations with milk fatty acids and proteins (absolute values ranging from 0.33 to 0.99). Genome-wide association studies revealed a QTL for alpha-lactalbumin concentration in milk on Ovis aries chromosome (OAR) 11, and six QTL for rumen bacterial abundances i.e., for two OTU belonging to the genera Prevotella (OAR3 and 5), Rikeneleaceae_RC9_gut_group (OAR5), Ruminococcus (OAR5), an unknown genus of order Clostridia UCG-014 (OAR10), and CAG-352 (OAR11). None of these detected regions are simultaneously associated with rumen bacterial abundance and dairy traits, but the bacterial families Prevotellaceae, Lachnospiraceae and F082 show colocalized signals on OAR3, 5, 15 and 26. CONCLUSIONS: In Lacaune dairy sheep, rumen microbiota abundance is partially controlled by the host genetics and is poorly genetically linked with milk protein and fatty acid compositions, and three main bacterial families, Prevotellaceae, Lachnospiraceae and F082, show specific associations with OAR3, 5, 15 and 26. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12711-022-00769-9. BioMed Central 2022-11-24 /pmc/articles/PMC9694848/ /pubmed/36434501 http://dx.doi.org/10.1186/s12711-022-00769-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Martinez Boggio, Guillermo
Meynadier, Annabelle
Buitenhuis, Albert Johannes
Marie-Etancelin, Christel
Host genetic control on rumen microbiota and its impact on dairy traits in sheep
title Host genetic control on rumen microbiota and its impact on dairy traits in sheep
title_full Host genetic control on rumen microbiota and its impact on dairy traits in sheep
title_fullStr Host genetic control on rumen microbiota and its impact on dairy traits in sheep
title_full_unstemmed Host genetic control on rumen microbiota and its impact on dairy traits in sheep
title_short Host genetic control on rumen microbiota and its impact on dairy traits in sheep
title_sort host genetic control on rumen microbiota and its impact on dairy traits in sheep
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694848/
https://www.ncbi.nlm.nih.gov/pubmed/36434501
http://dx.doi.org/10.1186/s12711-022-00769-9
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