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Association between Migraines and Prior Proton Pump Inhibitor Use: A Nested Case-Control Study Using a National Health Screening Cohort

The effect of proton pump inhibitor (PPI) use on migraine risk remains controversial. We explored the odds of migraines in relation to prior PPI use and treatment duration. Data from the Korean National Health Insurance Service-Health Screening Cohort (2002–2015) were analyzed in this nested case-co...

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Autores principales: Kang, Ho Suk, Kim, So Young, Kim, Ji Hee, Kim, Eun Soo, Choi, Hyo Geun, Lim, Hyun, Kim, Joo-Hee, Park, Ha Young, Kim, Nan Young, Hong, Sangkyoon, Choi, Kyung Chan, Kwon, Mi Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694889/
https://www.ncbi.nlm.nih.gov/pubmed/36355557
http://dx.doi.org/10.3390/ph15111385
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author Kang, Ho Suk
Kim, So Young
Kim, Ji Hee
Kim, Eun Soo
Choi, Hyo Geun
Lim, Hyun
Kim, Joo-Hee
Park, Ha Young
Kim, Nan Young
Hong, Sangkyoon
Choi, Kyung Chan
Kwon, Mi Jung
author_facet Kang, Ho Suk
Kim, So Young
Kim, Ji Hee
Kim, Eun Soo
Choi, Hyo Geun
Lim, Hyun
Kim, Joo-Hee
Park, Ha Young
Kim, Nan Young
Hong, Sangkyoon
Choi, Kyung Chan
Kwon, Mi Jung
author_sort Kang, Ho Suk
collection PubMed
description The effect of proton pump inhibitor (PPI) use on migraine risk remains controversial. We explored the odds of migraines in relation to prior PPI use and treatment duration. Data from the Korean National Health Insurance Service-Health Screening Cohort (2002–2015) were analyzed in this nested case-control study involving 28,159 participants with incident migraines and 112,636 controls (1:4 matched by sex, age, income, and residential region). The baseline covariates were balanced by performing propensity score overlap weighting-based adjustments, and the effect of prior PPI use (past vs. current) and treatment duration (<30 and 30–365 days vs. ≥365 days) on incident migraines was evaluated using logistic regression. In past and current PPI users, prior PPI use raised the likelihood of migraines (adjusted odds ratio [95% confidence interval]: 2.56 [2.36–2.79] and 4.66 [4.29–5.06], respectively). Participants who used PPI for <30, 30–365, or ≥365 days exhibited high odds of migraines (2.49 [2.29–2.72], 4.41 [4.05–4.79], and 4.14 [3.77–4.54], respectively). Incident migraines with or without aura also increased independently of PPI use history or duration. In summary, prior PPI use, irrespective of the elapsed time since use and the duration of use, is possibly associated with incident migraines with or without aura.
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spelling pubmed-96948892022-11-26 Association between Migraines and Prior Proton Pump Inhibitor Use: A Nested Case-Control Study Using a National Health Screening Cohort Kang, Ho Suk Kim, So Young Kim, Ji Hee Kim, Eun Soo Choi, Hyo Geun Lim, Hyun Kim, Joo-Hee Park, Ha Young Kim, Nan Young Hong, Sangkyoon Choi, Kyung Chan Kwon, Mi Jung Pharmaceuticals (Basel) Article The effect of proton pump inhibitor (PPI) use on migraine risk remains controversial. We explored the odds of migraines in relation to prior PPI use and treatment duration. Data from the Korean National Health Insurance Service-Health Screening Cohort (2002–2015) were analyzed in this nested case-control study involving 28,159 participants with incident migraines and 112,636 controls (1:4 matched by sex, age, income, and residential region). The baseline covariates were balanced by performing propensity score overlap weighting-based adjustments, and the effect of prior PPI use (past vs. current) and treatment duration (<30 and 30–365 days vs. ≥365 days) on incident migraines was evaluated using logistic regression. In past and current PPI users, prior PPI use raised the likelihood of migraines (adjusted odds ratio [95% confidence interval]: 2.56 [2.36–2.79] and 4.66 [4.29–5.06], respectively). Participants who used PPI for <30, 30–365, or ≥365 days exhibited high odds of migraines (2.49 [2.29–2.72], 4.41 [4.05–4.79], and 4.14 [3.77–4.54], respectively). Incident migraines with or without aura also increased independently of PPI use history or duration. In summary, prior PPI use, irrespective of the elapsed time since use and the duration of use, is possibly associated with incident migraines with or without aura. MDPI 2022-11-10 /pmc/articles/PMC9694889/ /pubmed/36355557 http://dx.doi.org/10.3390/ph15111385 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kang, Ho Suk
Kim, So Young
Kim, Ji Hee
Kim, Eun Soo
Choi, Hyo Geun
Lim, Hyun
Kim, Joo-Hee
Park, Ha Young
Kim, Nan Young
Hong, Sangkyoon
Choi, Kyung Chan
Kwon, Mi Jung
Association between Migraines and Prior Proton Pump Inhibitor Use: A Nested Case-Control Study Using a National Health Screening Cohort
title Association between Migraines and Prior Proton Pump Inhibitor Use: A Nested Case-Control Study Using a National Health Screening Cohort
title_full Association between Migraines and Prior Proton Pump Inhibitor Use: A Nested Case-Control Study Using a National Health Screening Cohort
title_fullStr Association between Migraines and Prior Proton Pump Inhibitor Use: A Nested Case-Control Study Using a National Health Screening Cohort
title_full_unstemmed Association between Migraines and Prior Proton Pump Inhibitor Use: A Nested Case-Control Study Using a National Health Screening Cohort
title_short Association between Migraines and Prior Proton Pump Inhibitor Use: A Nested Case-Control Study Using a National Health Screening Cohort
title_sort association between migraines and prior proton pump inhibitor use: a nested case-control study using a national health screening cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694889/
https://www.ncbi.nlm.nih.gov/pubmed/36355557
http://dx.doi.org/10.3390/ph15111385
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