Novel Uracil-Based Inhibitors of Acetylcholinesterase with Potency for Treating Memory Impairment in an Animal Model of Alzheimer’s Disease

Novel derivatives based on 6-methyluracil and condensed uracil, 2,4-quinazoline-2,4-dione, were synthesized with terminal meta- and para-benzoate moieties in polymethylene chains at the N atoms of the pyrimidine ring. In the synthesized compounds, the polymethylene chains were varied from having tri...

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Detalles Bibliográficos
Autores principales: Semenov, Vyacheslav E., Zueva, Irina V., Lushchekina, Sofya V., Suleimanov, Eduard G., Gubaidullina, Liliya M., Shulaeva, Marina M., Lenina, Oksana A., Petrov, Konstantin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694926/
https://www.ncbi.nlm.nih.gov/pubmed/36431954
http://dx.doi.org/10.3390/molecules27227855

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694926/
https://www.ncbi.nlm.nih.gov/pubmed/36431954
http://dx.doi.org/10.3390/molecules27227855

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