Cargando…

Structural Homology-Based Drug Repurposing Approach for Targeting NSP12 SARS-CoV-2

The severe acute respiratory syndrome coronavirus 2, also known as SARS-CoV-2, is the causative agent of the COVID-19 global pandemic. SARS-CoV-2 has a highly conserved non-structural protein 12 (NSP-12) involved in RNA-dependent RNA polymerase (RdRp) activity. For the identification of potential in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aljuaid, Abdulelah, Salam, Abdus, Almehmadi, Mazen, Baammi, Soukayna, Alshabrmi, Fahad M., Allahyani, Mamdouh, Al-Zaydi, Khadijah M., Izmirly, Abdullah M., Almaghrabi, Sarah, Baothman, Bandar K., Shahab, Muhammad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694939/ https://www.ncbi.nlm.nih.gov/pubmed/36431833 http://dx.doi.org/10.3390/molecules27227732

Ejemplares similares

Molecular Mimicry Analyses Unveiled the Human Herpes Simplex and Poxvirus Epitopes as Possible Candidates to Incite Autoimmunity
por: Begum, Sara, et al.
Publicado: (2022)

Identification of Small Molecule Inhibitors of Human Cytomegalovirus pUL89 Endonuclease Using Integrated Computational Approaches
por: Almehmadi, Mazen, et al.
Publicado: (2023)

Core Proteomics and Immunoinformatic Approaches to Design a Multiepitope Reverse Vaccine Candidate against Chagas Disease
por: Islam, Sk Injamamul, et al.
Publicado: (2022)

Atorvastatin and Fluvastatin Potentiate Blood Pressure Lowering Effect of Amlodipine through Vasorelaxant Phenomenon
por: Ali, Niaz, et al.
Publicado: (2023)

Phytochemical Profiling, Antioxidant, Antimicrobial and Cholinesterase Inhibitory Effects of Essential Oils Isolated from the Leaves of Artemisia scoparia and Artemisia absinthium
por: Khan, Farman Ali, et al.
Publicado: (2022)

In Silico Identification of Natural Product-Based Inhibitors Targeting IL-1β/IL-1R Protein–Protein Interface
por: Liu, Ting-ting, et al.
Publicado: (2023)

Assessing the adverse effects of COVID-19 vaccine in different scenarios in Saudi Arabia: A cross-sectional study
por: Alsaiari, Ahad Amer, et al.
Publicado: (2023)

g-C(3)N(4) Based Photocatalyst for the Efficient Photodegradation of Toxic Methyl Orange Dye: Recent Modifications and Future Perspectives
por: Aljuaid, Abdulelah, et al.
Publicado: (2023)

In Silico Screening and Molecular Dynamics Simulation Studies in the Identification of Natural Compound Inhibitors Targeting the Human Norovirus RdRp Protein to Fight Gastroenteritis
por: Obaid, Rami J., et al.
Publicado: (2023)

Detection of erythroid progenitors and erythrocytopathies in patients with severe COVID-19 disease
por: Allahyani, Mamdouh A., et al.
Publicado: (2022)

Trofinetide for Rett Syndrome: Highlights on the Development and Related Inventions of the First USFDA-Approved Treatment for Rare Pediatric Unmet Medical Need
por: Hudu, Shuaibu A., et al.
Publicado: (2023)

Highlights on the Development, Related Patents, and Prospects of Lenacapavir: The First-in-Class HIV-1 Capsid Inhibitor for the Treatment of Multi-Drug-Resistant HIV-1 Infection
por: Dzinamarira, Tafadzwa, et al.
Publicado: (2023)

In silico protein engineering shows that novel mutations affecting NAD(+) binding sites may improve phosphite dehydrogenase stability and activity
por: Baammi, Soukayna, et al.
Publicado: (2023)

Unleashing Nature’s potential: a computational approach to discovering novel VEGFR-2 inhibitors from African natural compound using virtual screening, ADMET analysis, molecular dynamics, and MMPBSA calculations
por: Baammi, Soukayna, et al.
Publicado: (2023)

CRISPR-Cas Genome Editing Technique for Fish Disease Management: Current Study and Future Perspective
por: Ferdous, Md. Akib, et al.
Publicado: (2022)

Antibacterial Effects of Commiphora gileadensis Methanolic Extract on Wound Healing
por: Alhazmi, Ayman, et al.
Publicado: (2022)

Microwave Assisted Synthesis, Part 1: Rapid Solventless Synthesis of 3-Substituted Coumarins and Benzocoumarins by Microwave Irradiation of the Corresponding Enaminones
por: Al-Zaydi, Khadijah M.
Publicado: (2003)

Green synthesis of MgO nanoparticles and its antibacterial properties
por: Rotti, Rajeshwari B., et al.
Publicado: (2023)

Eco-friendly synthesized nanoparticles as antimicrobial agents: an updated review
por: Borehalli Mayegowda, Shilpa, et al.
Publicado: (2023)

The Effects of Moxifloxacin and Gemifloxacin on the ECG Morphology in Healthy Volunteers: A Phase 1 Randomized Clinical Trial
por: Ullah, Abid, et al.
Publicado: (2023)

Investigation of Antistress and Antidepressant Activities of Synthetic Curcumin Analogues: Behavioral and Biomarker Approach
por: Hussain, Haya, et al.
Publicado: (2022)

In-Silico targeting of SARS-CoV-2 NSP6 for drug and natural products repurposing
por: Abdelkader, Ahmed, et al.
Publicado: (2022)

Association of the Red Cell Distribution Width With the Glycemic Index and Lipid Profile in Patients With Type 2 Diabetes Mellitus
por: Allahyani, Mamdouh
Publicado: (2023)

In silico structure modelling of SARS-CoV-2 Nsp13 helicase and Nsp14 and repurposing of FDA approved antiviral drugs as dual inhibitors
por: Gurung, Arun Bahadur
Publicado: (2020)

Vancomycin as an Antibacterial Agent Capped with Silver Nanoparticles: An Experimental Potential Analysis
por: Patwekar, Mohsina, et al.
Publicado: (2022)

2-Arylhydrazonopropanals as Building Blocks in Heterocyclic Chemistry: Microwave Assisted Condensation of 2-Aryl-hydrazonopropanals with Amines and Active Methylene Reagents
por: Al-Zaydi, Khadijah M., et al.
Publicado: (2003)

Synthetic Mono-Carbonyl Curcumin Analogues Attenuate Oxidative Stress in Mouse Models
por: Hussain, Haya, et al.
Publicado: (2022)

Ethnobotanical Study of Medicinal Plants Used against COVID-19
por: Chebaibi, Mohamed, et al.
Publicado: (2022)

Synergistic interactions of repurposed drugs that inhibit Nsp1, a major virulence factor for COVID-19
por: Kao, Hung-Teh, et al.
Publicado: (2022)

Exploring potent aldose reductase inhibitors for anti-diabetic (anti-hyperglycemic) therapy: integrating structure-based drug design, and MMGBSA approaches
por: Shahab, Muhammad, et al.
Publicado: (2023)

Bis(pyridine)enaminone as a Precursor for the Synthesis of Bis(azoles) and Bis(azine) Utilizing Recent Economic Green Chemistry Technology: The Q-Tube System
por: Al-Zaydi, Khadijah M., et al.
Publicado: (2023)

PEGylated Graphene Oxide as a Nanodrug Delivery Vehicle for Podophyllotoxin (GO/PEG/PTOX) and In Vitro α-Amylase/α-Glucosidase Inhibition Activities
por: Islam, Fawad, et al.
Publicado: (2023)

Structural and Dynamic Insights into the W68L, L85P, and T87A Mutations of Mycobacterium tuberculosis Inducing Resistance to Pyrazinamide
por: Alatawi, Eid A., et al.
Publicado: (2022)

Coronavirus NSP6 protein (nsp6)
Publicado: (2014)

Association Between Random Glucose Level and Leukocytes Count in Female Cancer Patients
por: Almehmadi, Mazen M
Publicado: (2020)

A Glance at the Development and Patent Literature of Tecovirimat: The First-in-Class Therapy for Emerging Monkeypox Outbreak
por: Almehmadi, Mazen, et al.
Publicado: (2022)

Repurposing Disulfiram as an Anti-Obesity Drug: Treating and Preventing Obesity in High-Fat-Fed Rats
por: Omran, Ziad, et al.
Publicado: (2020)

Sonochemical Degradation of Benzothiophene (BT) in Deionized Water, Natural Water and Sea Water
por: Al-Zaydi, Khadijah M., et al.
Publicado: (2019)

Irradiation as a Promising Technology to Improve Bacteriological and Physicochemical Quality of Fish
por: Mohamed, Eman F. E., et al.
Publicado: (2023)

Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replication
por: Wilamowski, Mateusz, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_720g2jsare6103ij9768okatpm