Pathological 25 kDa C-Terminal Fragments of TDP-43 Are Present in Lymphoblastoid Cell Lines and Extracellular Vesicles from Patients Affected by Frontotemporal Lobar Degeneration and Neuronal Ceroidolipofuscinosis Carrying a GRN Mutation

Frontotemporal lobar degeneration (FTLD) is a complex disease, characterized by progressive degeneration of frontal and temporal lobes. Mutations in progranulin (GRN) gene have been found in up to 50% of patients with familial FTLD. Abnormal deposits of post-translationally-modified TAR DNA-binding...

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Detalles Bibliográficos
Autores principales: Cimini, Sara, Bellini, Sonia, Saraceno, Claudia, Benussi, Luisa, Ghidoni, Roberta, Giliani, Silvia Clara, Puoti, Gianfranco, Canafoglia, Laura, Giaccone, Giorgio, Rossi, Giacomina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694984/
https://www.ncbi.nlm.nih.gov/pubmed/36430231
http://dx.doi.org/10.3390/ijms232213753

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