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Biomedical Indicators of Patients with Non-Puerperal Mastitis: A Retrospective Study

Background: Non-puerperal mastitis (NPM), a recurrent chronic inflammation of non-lactating breast, often proves tremendous difficulty in treatment, and it may give rise to its complicated symptoms and unclear etiology. Furthermore, the clinical morbidity rate of NPM has been increasing in recent ye...

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Autores principales: Shi, Liang, Wu, Jing, Hu, Yue, Zhang, Xu, Li, Zhi, Xi, Pei-Wen, Wei, Ji-Fu, Ding, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695051/
https://www.ncbi.nlm.nih.gov/pubmed/36432503
http://dx.doi.org/10.3390/nu14224816
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author Shi, Liang
Wu, Jing
Hu, Yue
Zhang, Xu
Li, Zhi
Xi, Pei-Wen
Wei, Ji-Fu
Ding, Qiang
author_facet Shi, Liang
Wu, Jing
Hu, Yue
Zhang, Xu
Li, Zhi
Xi, Pei-Wen
Wei, Ji-Fu
Ding, Qiang
author_sort Shi, Liang
collection PubMed
description Background: Non-puerperal mastitis (NPM), a recurrent chronic inflammation of non-lactating breast, often proves tremendous difficulty in treatment, and it may give rise to its complicated symptoms and unclear etiology. Furthermore, the clinical morbidity rate of NPM has been increasing in recent years. Methods: Overall, 284 patients diagnosed with NPM were consecutively recruited as cases in this study, and patients with benign breast disease (n = 1128) were enrolled as control. The clinical, biomedical, and pathological indicators were analyzed. Univariate and multivariate logistic analysis were used to distinguish risks between NPM and benign breast mass patients. Furthermore, according to the pathological characteristics, the patients of NPM were classified into two subgroups: mammary duct ectasia (MDE) and granulomatous lobular mastitis (GLM). The differences of biomedical indicators between MDE and GLM groups were also analyzed. Results: Compared with benign breast mass group, the level of high-density lipoprotein (HDL-C) significantly decreased, while lipoprotein(a) (Lp(a)) and blood glucose (GLU) both increased in NPM group. According to univariate and multivariate logistic analysis, the onset age and HDL-C were generally decreased, while Lp(a) and GLU were increased in NPM group. The onset age, HDL-C, Lp(a), and GLU were modeled to distinguish NPM and benign breast mass. Significant differences were also observed between MDE and GLM patients in biomedical indicators, such as lipoprotein(a) (Lp(a)), lactate dehydrogenase (LDH), creatine kinase (CK), total cholesterol (TC), and so on. Conclusions: Our results indicated for the first time that biomarkers were associated with NPM. The biomedical indicators involved in lipid metabolism might be important factors in the development and treatment of NPM. In addition, MDE and GLM are two diseases with different inflammatory states of NPM. These findings would be helpful for a better understanding of NPM and give us some insights to develop new diagnostic and therapeutic strategies.
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spelling pubmed-96950512022-11-26 Biomedical Indicators of Patients with Non-Puerperal Mastitis: A Retrospective Study Shi, Liang Wu, Jing Hu, Yue Zhang, Xu Li, Zhi Xi, Pei-Wen Wei, Ji-Fu Ding, Qiang Nutrients Article Background: Non-puerperal mastitis (NPM), a recurrent chronic inflammation of non-lactating breast, often proves tremendous difficulty in treatment, and it may give rise to its complicated symptoms and unclear etiology. Furthermore, the clinical morbidity rate of NPM has been increasing in recent years. Methods: Overall, 284 patients diagnosed with NPM were consecutively recruited as cases in this study, and patients with benign breast disease (n = 1128) were enrolled as control. The clinical, biomedical, and pathological indicators were analyzed. Univariate and multivariate logistic analysis were used to distinguish risks between NPM and benign breast mass patients. Furthermore, according to the pathological characteristics, the patients of NPM were classified into two subgroups: mammary duct ectasia (MDE) and granulomatous lobular mastitis (GLM). The differences of biomedical indicators between MDE and GLM groups were also analyzed. Results: Compared with benign breast mass group, the level of high-density lipoprotein (HDL-C) significantly decreased, while lipoprotein(a) (Lp(a)) and blood glucose (GLU) both increased in NPM group. According to univariate and multivariate logistic analysis, the onset age and HDL-C were generally decreased, while Lp(a) and GLU were increased in NPM group. The onset age, HDL-C, Lp(a), and GLU were modeled to distinguish NPM and benign breast mass. Significant differences were also observed between MDE and GLM patients in biomedical indicators, such as lipoprotein(a) (Lp(a)), lactate dehydrogenase (LDH), creatine kinase (CK), total cholesterol (TC), and so on. Conclusions: Our results indicated for the first time that biomarkers were associated with NPM. The biomedical indicators involved in lipid metabolism might be important factors in the development and treatment of NPM. In addition, MDE and GLM are two diseases with different inflammatory states of NPM. These findings would be helpful for a better understanding of NPM and give us some insights to develop new diagnostic and therapeutic strategies. MDPI 2022-11-14 /pmc/articles/PMC9695051/ /pubmed/36432503 http://dx.doi.org/10.3390/nu14224816 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shi, Liang
Wu, Jing
Hu, Yue
Zhang, Xu
Li, Zhi
Xi, Pei-Wen
Wei, Ji-Fu
Ding, Qiang
Biomedical Indicators of Patients with Non-Puerperal Mastitis: A Retrospective Study
title Biomedical Indicators of Patients with Non-Puerperal Mastitis: A Retrospective Study
title_full Biomedical Indicators of Patients with Non-Puerperal Mastitis: A Retrospective Study
title_fullStr Biomedical Indicators of Patients with Non-Puerperal Mastitis: A Retrospective Study
title_full_unstemmed Biomedical Indicators of Patients with Non-Puerperal Mastitis: A Retrospective Study
title_short Biomedical Indicators of Patients with Non-Puerperal Mastitis: A Retrospective Study
title_sort biomedical indicators of patients with non-puerperal mastitis: a retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695051/
https://www.ncbi.nlm.nih.gov/pubmed/36432503
http://dx.doi.org/10.3390/nu14224816
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