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Integrating Mechanisms in Thrombotic Peripheral Arterial Disease

Peripheral arterial disease (PAD), a manifestation of systemic atherosclerosis, is underdiagnosed in the general population. Despite the extensive research performed to unravel its pathophysiology, inadequate knowledge exists, thus preventing the development of new treatments. This review aims to hi...

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Autores principales: Nagy, Magdolna, van der Meijden, Paola E. J., Glunz, Julia, Schurgers, Leon, Lutgens, Esther, ten Cate, Hugo, Heitmeier, Stefan, Spronk, Henri M. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695058/
https://www.ncbi.nlm.nih.gov/pubmed/36422558
http://dx.doi.org/10.3390/ph15111428
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author Nagy, Magdolna
van der Meijden, Paola E. J.
Glunz, Julia
Schurgers, Leon
Lutgens, Esther
ten Cate, Hugo
Heitmeier, Stefan
Spronk, Henri M. H.
author_facet Nagy, Magdolna
van der Meijden, Paola E. J.
Glunz, Julia
Schurgers, Leon
Lutgens, Esther
ten Cate, Hugo
Heitmeier, Stefan
Spronk, Henri M. H.
author_sort Nagy, Magdolna
collection PubMed
description Peripheral arterial disease (PAD), a manifestation of systemic atherosclerosis, is underdiagnosed in the general population. Despite the extensive research performed to unravel its pathophysiology, inadequate knowledge exists, thus preventing the development of new treatments. This review aims to highlight the essential elements of atherosclerosis contributing to the pathophysiology of PAD. Furthermore, emphasis will be placed on the role of thrombo-inflammation, with particular focus on platelet and coagulation activation as well as cell–cell interactions. Additional insight will be then discussed to reveal the contribution of hypercoagulability to the development of vascular diseases such as PAD. Lastly, the current antithrombotic treatments will be discussed, and light will be shed on promising new targets aiming to aid the development of new treatments.
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spelling pubmed-96950582022-11-26 Integrating Mechanisms in Thrombotic Peripheral Arterial Disease Nagy, Magdolna van der Meijden, Paola E. J. Glunz, Julia Schurgers, Leon Lutgens, Esther ten Cate, Hugo Heitmeier, Stefan Spronk, Henri M. H. Pharmaceuticals (Basel) Review Peripheral arterial disease (PAD), a manifestation of systemic atherosclerosis, is underdiagnosed in the general population. Despite the extensive research performed to unravel its pathophysiology, inadequate knowledge exists, thus preventing the development of new treatments. This review aims to highlight the essential elements of atherosclerosis contributing to the pathophysiology of PAD. Furthermore, emphasis will be placed on the role of thrombo-inflammation, with particular focus on platelet and coagulation activation as well as cell–cell interactions. Additional insight will be then discussed to reveal the contribution of hypercoagulability to the development of vascular diseases such as PAD. Lastly, the current antithrombotic treatments will be discussed, and light will be shed on promising new targets aiming to aid the development of new treatments. MDPI 2022-11-18 /pmc/articles/PMC9695058/ /pubmed/36422558 http://dx.doi.org/10.3390/ph15111428 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nagy, Magdolna
van der Meijden, Paola E. J.
Glunz, Julia
Schurgers, Leon
Lutgens, Esther
ten Cate, Hugo
Heitmeier, Stefan
Spronk, Henri M. H.
Integrating Mechanisms in Thrombotic Peripheral Arterial Disease
title Integrating Mechanisms in Thrombotic Peripheral Arterial Disease
title_full Integrating Mechanisms in Thrombotic Peripheral Arterial Disease
title_fullStr Integrating Mechanisms in Thrombotic Peripheral Arterial Disease
title_full_unstemmed Integrating Mechanisms in Thrombotic Peripheral Arterial Disease
title_short Integrating Mechanisms in Thrombotic Peripheral Arterial Disease
title_sort integrating mechanisms in thrombotic peripheral arterial disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695058/
https://www.ncbi.nlm.nih.gov/pubmed/36422558
http://dx.doi.org/10.3390/ph15111428
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