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Integrating Mechanisms in Thrombotic Peripheral Arterial Disease
Peripheral arterial disease (PAD), a manifestation of systemic atherosclerosis, is underdiagnosed in the general population. Despite the extensive research performed to unravel its pathophysiology, inadequate knowledge exists, thus preventing the development of new treatments. This review aims to hi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695058/ https://www.ncbi.nlm.nih.gov/pubmed/36422558 http://dx.doi.org/10.3390/ph15111428 |
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author | Nagy, Magdolna van der Meijden, Paola E. J. Glunz, Julia Schurgers, Leon Lutgens, Esther ten Cate, Hugo Heitmeier, Stefan Spronk, Henri M. H. |
author_facet | Nagy, Magdolna van der Meijden, Paola E. J. Glunz, Julia Schurgers, Leon Lutgens, Esther ten Cate, Hugo Heitmeier, Stefan Spronk, Henri M. H. |
author_sort | Nagy, Magdolna |
collection | PubMed |
description | Peripheral arterial disease (PAD), a manifestation of systemic atherosclerosis, is underdiagnosed in the general population. Despite the extensive research performed to unravel its pathophysiology, inadequate knowledge exists, thus preventing the development of new treatments. This review aims to highlight the essential elements of atherosclerosis contributing to the pathophysiology of PAD. Furthermore, emphasis will be placed on the role of thrombo-inflammation, with particular focus on platelet and coagulation activation as well as cell–cell interactions. Additional insight will be then discussed to reveal the contribution of hypercoagulability to the development of vascular diseases such as PAD. Lastly, the current antithrombotic treatments will be discussed, and light will be shed on promising new targets aiming to aid the development of new treatments. |
format | Online Article Text |
id | pubmed-9695058 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96950582022-11-26 Integrating Mechanisms in Thrombotic Peripheral Arterial Disease Nagy, Magdolna van der Meijden, Paola E. J. Glunz, Julia Schurgers, Leon Lutgens, Esther ten Cate, Hugo Heitmeier, Stefan Spronk, Henri M. H. Pharmaceuticals (Basel) Review Peripheral arterial disease (PAD), a manifestation of systemic atherosclerosis, is underdiagnosed in the general population. Despite the extensive research performed to unravel its pathophysiology, inadequate knowledge exists, thus preventing the development of new treatments. This review aims to highlight the essential elements of atherosclerosis contributing to the pathophysiology of PAD. Furthermore, emphasis will be placed on the role of thrombo-inflammation, with particular focus on platelet and coagulation activation as well as cell–cell interactions. Additional insight will be then discussed to reveal the contribution of hypercoagulability to the development of vascular diseases such as PAD. Lastly, the current antithrombotic treatments will be discussed, and light will be shed on promising new targets aiming to aid the development of new treatments. MDPI 2022-11-18 /pmc/articles/PMC9695058/ /pubmed/36422558 http://dx.doi.org/10.3390/ph15111428 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nagy, Magdolna van der Meijden, Paola E. J. Glunz, Julia Schurgers, Leon Lutgens, Esther ten Cate, Hugo Heitmeier, Stefan Spronk, Henri M. H. Integrating Mechanisms in Thrombotic Peripheral Arterial Disease |
title | Integrating Mechanisms in Thrombotic Peripheral Arterial Disease |
title_full | Integrating Mechanisms in Thrombotic Peripheral Arterial Disease |
title_fullStr | Integrating Mechanisms in Thrombotic Peripheral Arterial Disease |
title_full_unstemmed | Integrating Mechanisms in Thrombotic Peripheral Arterial Disease |
title_short | Integrating Mechanisms in Thrombotic Peripheral Arterial Disease |
title_sort | integrating mechanisms in thrombotic peripheral arterial disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695058/ https://www.ncbi.nlm.nih.gov/pubmed/36422558 http://dx.doi.org/10.3390/ph15111428 |
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