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Nucleic Acid Vaccines against SARS-CoV-2

The coronavirus disease 2019 (COVID-19) has spread worldwide and imposed a substantial burden on human health, the environment, and socioeconomic development, which has also accelerated the process of nucleic acid vaccine development and licensure. Nucleic acid vaccines are viral genetic sequence-ba...

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Detalles Bibliográficos
Autores principales: Liu, Ying, Ye, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695141/
https://www.ncbi.nlm.nih.gov/pubmed/36366358
http://dx.doi.org/10.3390/vaccines10111849
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author Liu, Ying
Ye, Qing
author_facet Liu, Ying
Ye, Qing
author_sort Liu, Ying
collection PubMed
description The coronavirus disease 2019 (COVID-19) has spread worldwide and imposed a substantial burden on human health, the environment, and socioeconomic development, which has also accelerated the process of nucleic acid vaccine development and licensure. Nucleic acid vaccines are viral genetic sequence-based vaccines and third-generation vaccines after whole virus vaccines and recombinant subunit vaccines, including DNA vaccines and RNA vaccines. They have many unique advantages, but there are many aspects that require optimization. Therefore, the purpose of this review is to discuss the research and development processes of nucleic acid vaccines, summarize the advantages and shortcomings, and propose further optimization strategies by taking COVID-19 vaccines as an example. Hopefully, this work can make a modest contribution in promoting the construction of emergency nucleic acid vaccine platforms and in avoiding the reemergence of similar public health emergencies.
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spelling pubmed-96951412022-11-26 Nucleic Acid Vaccines against SARS-CoV-2 Liu, Ying Ye, Qing Vaccines (Basel) Review The coronavirus disease 2019 (COVID-19) has spread worldwide and imposed a substantial burden on human health, the environment, and socioeconomic development, which has also accelerated the process of nucleic acid vaccine development and licensure. Nucleic acid vaccines are viral genetic sequence-based vaccines and third-generation vaccines after whole virus vaccines and recombinant subunit vaccines, including DNA vaccines and RNA vaccines. They have many unique advantages, but there are many aspects that require optimization. Therefore, the purpose of this review is to discuss the research and development processes of nucleic acid vaccines, summarize the advantages and shortcomings, and propose further optimization strategies by taking COVID-19 vaccines as an example. Hopefully, this work can make a modest contribution in promoting the construction of emergency nucleic acid vaccine platforms and in avoiding the reemergence of similar public health emergencies. MDPI 2022-10-31 /pmc/articles/PMC9695141/ /pubmed/36366358 http://dx.doi.org/10.3390/vaccines10111849 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liu, Ying
Ye, Qing
Nucleic Acid Vaccines against SARS-CoV-2
title Nucleic Acid Vaccines against SARS-CoV-2
title_full Nucleic Acid Vaccines against SARS-CoV-2
title_fullStr Nucleic Acid Vaccines against SARS-CoV-2
title_full_unstemmed Nucleic Acid Vaccines against SARS-CoV-2
title_short Nucleic Acid Vaccines against SARS-CoV-2
title_sort nucleic acid vaccines against sars-cov-2
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695141/
https://www.ncbi.nlm.nih.gov/pubmed/36366358
http://dx.doi.org/10.3390/vaccines10111849
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