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Impact of Dysfunctional Adipose Tissue Depots on the Cardiovascular System
Obesity with its associated complications represents a social, economic and health problem of utmost importance worldwide. Specifically, obese patients carry a significantly higher risk of developing cardiovascular disease compared to nonobese individuals. Multiple molecular mechanisms contribute to...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695168/ https://www.ncbi.nlm.nih.gov/pubmed/36430774 http://dx.doi.org/10.3390/ijms232214296 |
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author | D’Oria, Rossella Genchi, Valentina Annamaria Caccioppoli, Cristina Calderoni, Isabella Marrano, Nicola Biondi, Giuseppina Borrelli, Anna Di Gioia, Ludovico Giorgino, Francesco Laviola, Luigi |
author_facet | D’Oria, Rossella Genchi, Valentina Annamaria Caccioppoli, Cristina Calderoni, Isabella Marrano, Nicola Biondi, Giuseppina Borrelli, Anna Di Gioia, Ludovico Giorgino, Francesco Laviola, Luigi |
author_sort | D’Oria, Rossella |
collection | PubMed |
description | Obesity with its associated complications represents a social, economic and health problem of utmost importance worldwide. Specifically, obese patients carry a significantly higher risk of developing cardiovascular disease compared to nonobese individuals. Multiple molecular mechanisms contribute to the impaired biological activity of the distinct adipose tissue depots in obesity, including secretion of proinflammatory mediators and reactive oxygen species, ultimately leading to an unfavorable impact on the cardiovascular system. This review summarizes data relating to the contribution of the main adipose tissue depots, including both remote (i.e., intra-abdominal, hepatic, skeletal, pancreatic, renal, and mesenteric adipose fat), and cardiac (i.e., the epicardial fat) adipose locations, on the cardiovascular system. Finally, we discuss both pharmacological and non-pharmacological strategies aimed at reducing cardiovascular risk through acting on adipose tissues, with particular attention to the epicardial fat. |
format | Online Article Text |
id | pubmed-9695168 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96951682022-11-26 Impact of Dysfunctional Adipose Tissue Depots on the Cardiovascular System D’Oria, Rossella Genchi, Valentina Annamaria Caccioppoli, Cristina Calderoni, Isabella Marrano, Nicola Biondi, Giuseppina Borrelli, Anna Di Gioia, Ludovico Giorgino, Francesco Laviola, Luigi Int J Mol Sci Review Obesity with its associated complications represents a social, economic and health problem of utmost importance worldwide. Specifically, obese patients carry a significantly higher risk of developing cardiovascular disease compared to nonobese individuals. Multiple molecular mechanisms contribute to the impaired biological activity of the distinct adipose tissue depots in obesity, including secretion of proinflammatory mediators and reactive oxygen species, ultimately leading to an unfavorable impact on the cardiovascular system. This review summarizes data relating to the contribution of the main adipose tissue depots, including both remote (i.e., intra-abdominal, hepatic, skeletal, pancreatic, renal, and mesenteric adipose fat), and cardiac (i.e., the epicardial fat) adipose locations, on the cardiovascular system. Finally, we discuss both pharmacological and non-pharmacological strategies aimed at reducing cardiovascular risk through acting on adipose tissues, with particular attention to the epicardial fat. MDPI 2022-11-18 /pmc/articles/PMC9695168/ /pubmed/36430774 http://dx.doi.org/10.3390/ijms232214296 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review D’Oria, Rossella Genchi, Valentina Annamaria Caccioppoli, Cristina Calderoni, Isabella Marrano, Nicola Biondi, Giuseppina Borrelli, Anna Di Gioia, Ludovico Giorgino, Francesco Laviola, Luigi Impact of Dysfunctional Adipose Tissue Depots on the Cardiovascular System |
title | Impact of Dysfunctional Adipose Tissue Depots on the Cardiovascular System |
title_full | Impact of Dysfunctional Adipose Tissue Depots on the Cardiovascular System |
title_fullStr | Impact of Dysfunctional Adipose Tissue Depots on the Cardiovascular System |
title_full_unstemmed | Impact of Dysfunctional Adipose Tissue Depots on the Cardiovascular System |
title_short | Impact of Dysfunctional Adipose Tissue Depots on the Cardiovascular System |
title_sort | impact of dysfunctional adipose tissue depots on the cardiovascular system |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695168/ https://www.ncbi.nlm.nih.gov/pubmed/36430774 http://dx.doi.org/10.3390/ijms232214296 |
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