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Impact of Dysfunctional Adipose Tissue Depots on the Cardiovascular System

Obesity with its associated complications represents a social, economic and health problem of utmost importance worldwide. Specifically, obese patients carry a significantly higher risk of developing cardiovascular disease compared to nonobese individuals. Multiple molecular mechanisms contribute to...

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Autores principales: D’Oria, Rossella, Genchi, Valentina Annamaria, Caccioppoli, Cristina, Calderoni, Isabella, Marrano, Nicola, Biondi, Giuseppina, Borrelli, Anna, Di Gioia, Ludovico, Giorgino, Francesco, Laviola, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695168/
https://www.ncbi.nlm.nih.gov/pubmed/36430774
http://dx.doi.org/10.3390/ijms232214296
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author D’Oria, Rossella
Genchi, Valentina Annamaria
Caccioppoli, Cristina
Calderoni, Isabella
Marrano, Nicola
Biondi, Giuseppina
Borrelli, Anna
Di Gioia, Ludovico
Giorgino, Francesco
Laviola, Luigi
author_facet D’Oria, Rossella
Genchi, Valentina Annamaria
Caccioppoli, Cristina
Calderoni, Isabella
Marrano, Nicola
Biondi, Giuseppina
Borrelli, Anna
Di Gioia, Ludovico
Giorgino, Francesco
Laviola, Luigi
author_sort D’Oria, Rossella
collection PubMed
description Obesity with its associated complications represents a social, economic and health problem of utmost importance worldwide. Specifically, obese patients carry a significantly higher risk of developing cardiovascular disease compared to nonobese individuals. Multiple molecular mechanisms contribute to the impaired biological activity of the distinct adipose tissue depots in obesity, including secretion of proinflammatory mediators and reactive oxygen species, ultimately leading to an unfavorable impact on the cardiovascular system. This review summarizes data relating to the contribution of the main adipose tissue depots, including both remote (i.e., intra-abdominal, hepatic, skeletal, pancreatic, renal, and mesenteric adipose fat), and cardiac (i.e., the epicardial fat) adipose locations, on the cardiovascular system. Finally, we discuss both pharmacological and non-pharmacological strategies aimed at reducing cardiovascular risk through acting on adipose tissues, with particular attention to the epicardial fat.
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spelling pubmed-96951682022-11-26 Impact of Dysfunctional Adipose Tissue Depots on the Cardiovascular System D’Oria, Rossella Genchi, Valentina Annamaria Caccioppoli, Cristina Calderoni, Isabella Marrano, Nicola Biondi, Giuseppina Borrelli, Anna Di Gioia, Ludovico Giorgino, Francesco Laviola, Luigi Int J Mol Sci Review Obesity with its associated complications represents a social, economic and health problem of utmost importance worldwide. Specifically, obese patients carry a significantly higher risk of developing cardiovascular disease compared to nonobese individuals. Multiple molecular mechanisms contribute to the impaired biological activity of the distinct adipose tissue depots in obesity, including secretion of proinflammatory mediators and reactive oxygen species, ultimately leading to an unfavorable impact on the cardiovascular system. This review summarizes data relating to the contribution of the main adipose tissue depots, including both remote (i.e., intra-abdominal, hepatic, skeletal, pancreatic, renal, and mesenteric adipose fat), and cardiac (i.e., the epicardial fat) adipose locations, on the cardiovascular system. Finally, we discuss both pharmacological and non-pharmacological strategies aimed at reducing cardiovascular risk through acting on adipose tissues, with particular attention to the epicardial fat. MDPI 2022-11-18 /pmc/articles/PMC9695168/ /pubmed/36430774 http://dx.doi.org/10.3390/ijms232214296 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
D’Oria, Rossella
Genchi, Valentina Annamaria
Caccioppoli, Cristina
Calderoni, Isabella
Marrano, Nicola
Biondi, Giuseppina
Borrelli, Anna
Di Gioia, Ludovico
Giorgino, Francesco
Laviola, Luigi
Impact of Dysfunctional Adipose Tissue Depots on the Cardiovascular System
title Impact of Dysfunctional Adipose Tissue Depots on the Cardiovascular System
title_full Impact of Dysfunctional Adipose Tissue Depots on the Cardiovascular System
title_fullStr Impact of Dysfunctional Adipose Tissue Depots on the Cardiovascular System
title_full_unstemmed Impact of Dysfunctional Adipose Tissue Depots on the Cardiovascular System
title_short Impact of Dysfunctional Adipose Tissue Depots on the Cardiovascular System
title_sort impact of dysfunctional adipose tissue depots on the cardiovascular system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695168/
https://www.ncbi.nlm.nih.gov/pubmed/36430774
http://dx.doi.org/10.3390/ijms232214296
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