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Thickness of Biceps and Quadriceps Femoris Muscle Measured Using Point-of-Care Ultrasound as a Representation of Total Skeletal Muscle Mass

Generalized loss of muscle mass is associated with increased morbidity and mortality in patients with cancer. The gold standard to measure muscle mass is by using computed tomography (CT). However, the aim of this prospective observational cohort study was to determine whether point-of-care ultrasou...

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Autores principales: Hogenbirk, Rianne N. M., Viddeleer, Alain R., Hentzen, Judith E. K. R., van der Plas, Willemijn Y., van der Schans, Cees P., de Bock, Geertruida H., Kruijff, Schelto, Klaase, Joost M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695176/
https://www.ncbi.nlm.nih.gov/pubmed/36431082
http://dx.doi.org/10.3390/jcm11226606
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author Hogenbirk, Rianne N. M.
Viddeleer, Alain R.
Hentzen, Judith E. K. R.
van der Plas, Willemijn Y.
van der Schans, Cees P.
de Bock, Geertruida H.
Kruijff, Schelto
Klaase, Joost M.
author_facet Hogenbirk, Rianne N. M.
Viddeleer, Alain R.
Hentzen, Judith E. K. R.
van der Plas, Willemijn Y.
van der Schans, Cees P.
de Bock, Geertruida H.
Kruijff, Schelto
Klaase, Joost M.
author_sort Hogenbirk, Rianne N. M.
collection PubMed
description Generalized loss of muscle mass is associated with increased morbidity and mortality in patients with cancer. The gold standard to measure muscle mass is by using computed tomography (CT). However, the aim of this prospective observational cohort study was to determine whether point-of-care ultrasound (POCUS) could be an easy-to-use, bedside measurement alternative to evaluate muscle status. Patients scheduled for major abdominal cancer surgery with a recent preoperative CT scan available were included. POCUS was used to measure the muscle thickness of mm. biceps brachii, mm. recti femoris, and mm. vasti intermedius 1 day prior to surgery. The total skeletal muscle index (SMI) was derived from patients’ abdominal CT scan at the third lumbar level. Muscle force of the upper and lower extremities was measured using a handheld dynamometer. A total of 165 patients were included (55% male; 65 ± 12 years). All POCUS measurements of muscle thickness had a statistically significant correlation with CT-derived SMI (r ≥ 0.48; p < 0.001). The strongest correlation between POCUS muscle measurements and SMI was observed when all POCUS muscle groups were added together (r = 0.73; p < 0.001). Muscle strength had a stronger correlation with POCUS-measured muscle thickness than with CT-derived SMI. To conclude, this study indicated a strong correlation between combined muscle thickness measurements performed by POCUS- and CT-derived SMI and measurements of muscle strength. These results suggest that handheld ultrasound is a valid tool for the assessment of skeletal muscle status.
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spelling pubmed-96951762022-11-26 Thickness of Biceps and Quadriceps Femoris Muscle Measured Using Point-of-Care Ultrasound as a Representation of Total Skeletal Muscle Mass Hogenbirk, Rianne N. M. Viddeleer, Alain R. Hentzen, Judith E. K. R. van der Plas, Willemijn Y. van der Schans, Cees P. de Bock, Geertruida H. Kruijff, Schelto Klaase, Joost M. J Clin Med Article Generalized loss of muscle mass is associated with increased morbidity and mortality in patients with cancer. The gold standard to measure muscle mass is by using computed tomography (CT). However, the aim of this prospective observational cohort study was to determine whether point-of-care ultrasound (POCUS) could be an easy-to-use, bedside measurement alternative to evaluate muscle status. Patients scheduled for major abdominal cancer surgery with a recent preoperative CT scan available were included. POCUS was used to measure the muscle thickness of mm. biceps brachii, mm. recti femoris, and mm. vasti intermedius 1 day prior to surgery. The total skeletal muscle index (SMI) was derived from patients’ abdominal CT scan at the third lumbar level. Muscle force of the upper and lower extremities was measured using a handheld dynamometer. A total of 165 patients were included (55% male; 65 ± 12 years). All POCUS measurements of muscle thickness had a statistically significant correlation with CT-derived SMI (r ≥ 0.48; p < 0.001). The strongest correlation between POCUS muscle measurements and SMI was observed when all POCUS muscle groups were added together (r = 0.73; p < 0.001). Muscle strength had a stronger correlation with POCUS-measured muscle thickness than with CT-derived SMI. To conclude, this study indicated a strong correlation between combined muscle thickness measurements performed by POCUS- and CT-derived SMI and measurements of muscle strength. These results suggest that handheld ultrasound is a valid tool for the assessment of skeletal muscle status. MDPI 2022-11-08 /pmc/articles/PMC9695176/ /pubmed/36431082 http://dx.doi.org/10.3390/jcm11226606 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hogenbirk, Rianne N. M.
Viddeleer, Alain R.
Hentzen, Judith E. K. R.
van der Plas, Willemijn Y.
van der Schans, Cees P.
de Bock, Geertruida H.
Kruijff, Schelto
Klaase, Joost M.
Thickness of Biceps and Quadriceps Femoris Muscle Measured Using Point-of-Care Ultrasound as a Representation of Total Skeletal Muscle Mass
title Thickness of Biceps and Quadriceps Femoris Muscle Measured Using Point-of-Care Ultrasound as a Representation of Total Skeletal Muscle Mass
title_full Thickness of Biceps and Quadriceps Femoris Muscle Measured Using Point-of-Care Ultrasound as a Representation of Total Skeletal Muscle Mass
title_fullStr Thickness of Biceps and Quadriceps Femoris Muscle Measured Using Point-of-Care Ultrasound as a Representation of Total Skeletal Muscle Mass
title_full_unstemmed Thickness of Biceps and Quadriceps Femoris Muscle Measured Using Point-of-Care Ultrasound as a Representation of Total Skeletal Muscle Mass
title_short Thickness of Biceps and Quadriceps Femoris Muscle Measured Using Point-of-Care Ultrasound as a Representation of Total Skeletal Muscle Mass
title_sort thickness of biceps and quadriceps femoris muscle measured using point-of-care ultrasound as a representation of total skeletal muscle mass
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695176/
https://www.ncbi.nlm.nih.gov/pubmed/36431082
http://dx.doi.org/10.3390/jcm11226606
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