Cargando…

Gotta Go Slow: Two Evolutionarily Distinct Annelids Retain a Common Hedgehog Pathway Composition, Outlining Its Pan-Bilaterian Core

Hedgehog signaling is one of the key regulators of morphogenesis, cell differentiation, and regeneration. While the Hh pathway is present in all bilaterians, it has mainly been studied in model animals such as Drosophila and vertebrates. Despite the conservatism of its core components, mechanisms of...

Descripción completa

Detalles Bibliográficos
Autores principales: Platova, Sofia, Poliushkevich, Liudmila, Kulakova, Milana, Nesterenko, Maksim, Starunov, Viktor, Novikova, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695228/
https://www.ncbi.nlm.nih.gov/pubmed/36430788
http://dx.doi.org/10.3390/ijms232214312
_version_ 1784838003891372032
author Platova, Sofia
Poliushkevich, Liudmila
Kulakova, Milana
Nesterenko, Maksim
Starunov, Viktor
Novikova, Elena
author_facet Platova, Sofia
Poliushkevich, Liudmila
Kulakova, Milana
Nesterenko, Maksim
Starunov, Viktor
Novikova, Elena
author_sort Platova, Sofia
collection PubMed
description Hedgehog signaling is one of the key regulators of morphogenesis, cell differentiation, and regeneration. While the Hh pathway is present in all bilaterians, it has mainly been studied in model animals such as Drosophila and vertebrates. Despite the conservatism of its core components, mechanisms of signal transduction and additional components vary in Ecdysozoa and Deuterostomia. Vertebrates have multiple copies of the pathway members, which complicates signaling implementation, whereas model ecdysozoans appear to have lost some components due to fast evolution rates. To shed light on the ancestral state of Hh signaling, models from the third clade, Spiralia, are needed. In our research, we analyzed the transcriptomes of two spiralian animals, errantial annelid Platynereis dumerilii (Nereididae) and sedentarian annelid Pygospio elegans (Spionidae). We found that both annelids express almost all Hh pathway components present in Drosophila and mouse. We performed a phylogenetic analysis of the core pathway components and built multiple sequence alignments of the additional key members. Our results imply that the Hh pathway compositions of both annelids share more similarities with vertebrates than with the fruit fly. Possessing an almost complete set of single-copy Hh pathway members, lophotrochozoan signaling composition may reflect the ancestral features of all three bilaterian branches.
format Online
Article
Text
id pubmed-9695228
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96952282022-11-26 Gotta Go Slow: Two Evolutionarily Distinct Annelids Retain a Common Hedgehog Pathway Composition, Outlining Its Pan-Bilaterian Core Platova, Sofia Poliushkevich, Liudmila Kulakova, Milana Nesterenko, Maksim Starunov, Viktor Novikova, Elena Int J Mol Sci Article Hedgehog signaling is one of the key regulators of morphogenesis, cell differentiation, and regeneration. While the Hh pathway is present in all bilaterians, it has mainly been studied in model animals such as Drosophila and vertebrates. Despite the conservatism of its core components, mechanisms of signal transduction and additional components vary in Ecdysozoa and Deuterostomia. Vertebrates have multiple copies of the pathway members, which complicates signaling implementation, whereas model ecdysozoans appear to have lost some components due to fast evolution rates. To shed light on the ancestral state of Hh signaling, models from the third clade, Spiralia, are needed. In our research, we analyzed the transcriptomes of two spiralian animals, errantial annelid Platynereis dumerilii (Nereididae) and sedentarian annelid Pygospio elegans (Spionidae). We found that both annelids express almost all Hh pathway components present in Drosophila and mouse. We performed a phylogenetic analysis of the core pathway components and built multiple sequence alignments of the additional key members. Our results imply that the Hh pathway compositions of both annelids share more similarities with vertebrates than with the fruit fly. Possessing an almost complete set of single-copy Hh pathway members, lophotrochozoan signaling composition may reflect the ancestral features of all three bilaterian branches. MDPI 2022-11-18 /pmc/articles/PMC9695228/ /pubmed/36430788 http://dx.doi.org/10.3390/ijms232214312 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Platova, Sofia
Poliushkevich, Liudmila
Kulakova, Milana
Nesterenko, Maksim
Starunov, Viktor
Novikova, Elena
Gotta Go Slow: Two Evolutionarily Distinct Annelids Retain a Common Hedgehog Pathway Composition, Outlining Its Pan-Bilaterian Core
title Gotta Go Slow: Two Evolutionarily Distinct Annelids Retain a Common Hedgehog Pathway Composition, Outlining Its Pan-Bilaterian Core
title_full Gotta Go Slow: Two Evolutionarily Distinct Annelids Retain a Common Hedgehog Pathway Composition, Outlining Its Pan-Bilaterian Core
title_fullStr Gotta Go Slow: Two Evolutionarily Distinct Annelids Retain a Common Hedgehog Pathway Composition, Outlining Its Pan-Bilaterian Core
title_full_unstemmed Gotta Go Slow: Two Evolutionarily Distinct Annelids Retain a Common Hedgehog Pathway Composition, Outlining Its Pan-Bilaterian Core
title_short Gotta Go Slow: Two Evolutionarily Distinct Annelids Retain a Common Hedgehog Pathway Composition, Outlining Its Pan-Bilaterian Core
title_sort gotta go slow: two evolutionarily distinct annelids retain a common hedgehog pathway composition, outlining its pan-bilaterian core
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695228/
https://www.ncbi.nlm.nih.gov/pubmed/36430788
http://dx.doi.org/10.3390/ijms232214312
work_keys_str_mv AT platovasofia gottagoslowtwoevolutionarilydistinctannelidsretainacommonhedgehogpathwaycompositionoutliningitspanbilateriancore
AT poliushkevichliudmila gottagoslowtwoevolutionarilydistinctannelidsretainacommonhedgehogpathwaycompositionoutliningitspanbilateriancore
AT kulakovamilana gottagoslowtwoevolutionarilydistinctannelidsretainacommonhedgehogpathwaycompositionoutliningitspanbilateriancore
AT nesterenkomaksim gottagoslowtwoevolutionarilydistinctannelidsretainacommonhedgehogpathwaycompositionoutliningitspanbilateriancore
AT starunovviktor gottagoslowtwoevolutionarilydistinctannelidsretainacommonhedgehogpathwaycompositionoutliningitspanbilateriancore
AT novikovaelena gottagoslowtwoevolutionarilydistinctannelidsretainacommonhedgehogpathwaycompositionoutliningitspanbilateriancore