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Formulation of the Polysaccharide FucoPol into Novel Emulsified Creams with Improved Physicochemical Properties

Driven by the customers’ growing awareness of environmental issues, the production of topical formulations based on sustainable ingredients is receiving widespread attention from researchers and the industry. Although numerous sustainable ingredients (natural, organic, or green chemistry-derived com...

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Autores principales: Baptista, Sílvia, Freitas, Filomena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695255/
https://www.ncbi.nlm.nih.gov/pubmed/36431860
http://dx.doi.org/10.3390/molecules27227759
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author Baptista, Sílvia
Freitas, Filomena
author_facet Baptista, Sílvia
Freitas, Filomena
author_sort Baptista, Sílvia
collection PubMed
description Driven by the customers’ growing awareness of environmental issues, the production of topical formulations based on sustainable ingredients is receiving widespread attention from researchers and the industry. Although numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds) have been investigated, there is a lack of comparative studies between conventional ingredients and sustainable alternatives. In this study, olive oil (30 wt.%) and α-tocopherol (2.5 wt.%) containing oil-in-water (O/W) emulsions stabilized with the bacterial fucose-rich polysaccharide FucoPol were formulated envisaging their validation as cosmetic creams. After formula composition design by Response Surface Methodology (RSM), the optimized FucoPol-based emulsion was prepared with 1.5 wt.% FucoPol, 1.5 wt.% cetyl alcohol, and 3.0 wt.% glycerin. The resulting emulsions had an apparent viscosity of 8.72 Pa.s (measured at a shear rate 2.3 s(−1)) and droplet size and zeta potential values of 6.12 µm and −97.9 mV, respectively, which are within the values reported for cosmetic emulsified formulations. The optimized formulation displayed the desired criterium of a thin emulsion system, possessing the physicochemical properties and the stability comparable to those of commercially available products used in cosmeceutical applications.
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spelling pubmed-96952552022-11-26 Formulation of the Polysaccharide FucoPol into Novel Emulsified Creams with Improved Physicochemical Properties Baptista, Sílvia Freitas, Filomena Molecules Article Driven by the customers’ growing awareness of environmental issues, the production of topical formulations based on sustainable ingredients is receiving widespread attention from researchers and the industry. Although numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds) have been investigated, there is a lack of comparative studies between conventional ingredients and sustainable alternatives. In this study, olive oil (30 wt.%) and α-tocopherol (2.5 wt.%) containing oil-in-water (O/W) emulsions stabilized with the bacterial fucose-rich polysaccharide FucoPol were formulated envisaging their validation as cosmetic creams. After formula composition design by Response Surface Methodology (RSM), the optimized FucoPol-based emulsion was prepared with 1.5 wt.% FucoPol, 1.5 wt.% cetyl alcohol, and 3.0 wt.% glycerin. The resulting emulsions had an apparent viscosity of 8.72 Pa.s (measured at a shear rate 2.3 s(−1)) and droplet size and zeta potential values of 6.12 µm and −97.9 mV, respectively, which are within the values reported for cosmetic emulsified formulations. The optimized formulation displayed the desired criterium of a thin emulsion system, possessing the physicochemical properties and the stability comparable to those of commercially available products used in cosmeceutical applications. MDPI 2022-11-10 /pmc/articles/PMC9695255/ /pubmed/36431860 http://dx.doi.org/10.3390/molecules27227759 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Baptista, Sílvia
Freitas, Filomena
Formulation of the Polysaccharide FucoPol into Novel Emulsified Creams with Improved Physicochemical Properties
title Formulation of the Polysaccharide FucoPol into Novel Emulsified Creams with Improved Physicochemical Properties
title_full Formulation of the Polysaccharide FucoPol into Novel Emulsified Creams with Improved Physicochemical Properties
title_fullStr Formulation of the Polysaccharide FucoPol into Novel Emulsified Creams with Improved Physicochemical Properties
title_full_unstemmed Formulation of the Polysaccharide FucoPol into Novel Emulsified Creams with Improved Physicochemical Properties
title_short Formulation of the Polysaccharide FucoPol into Novel Emulsified Creams with Improved Physicochemical Properties
title_sort formulation of the polysaccharide fucopol into novel emulsified creams with improved physicochemical properties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695255/
https://www.ncbi.nlm.nih.gov/pubmed/36431860
http://dx.doi.org/10.3390/molecules27227759
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