Dual Targeting of MDM4 and FTH1 by MMRi71 for Induced Protein Degradation and p53-Independent Apoptosis in Leukemia Cells

MDM2 and MDM4 are cancer drug targets validated in multiple models for p53-based cancer therapies. The RING domains of MDM2 and non-p53-binder MDM2 splice isoforms form RING domain heterodimer polyubiquitin E3 ligases with MDM4, which regulate p53 stability in vivo and promote tumorigenesis independ...

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Detalles Bibliográficos
Autores principales: Lama, Rati, Galster, Samuel L., Xu, Chao, Davison, Luke W., Chemler, Sherry R., Wang, Xinjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695299/
https://www.ncbi.nlm.nih.gov/pubmed/36431769
http://dx.doi.org/10.3390/molecules27227665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695299/
https://www.ncbi.nlm.nih.gov/pubmed/36431769
http://dx.doi.org/10.3390/molecules27227665

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