Cargando…

SARS-CoV-2 and Dengue Virus Coinfection in a Mexican Pediatric Patient: A Case Report from Early Molecular Diagnosis

Mexico is an endemic region for dengue virus (DENV). The increase in this disease coincides with outbreaks of COVID-19, both of which are single-stranded positive RNA viruses. These characteristics make it difficult to distinguish each disease because they share clinical and laboratory features, whi...

Descripción completa

Detalles Bibliográficos
Autores principales: Zepeda-Carrillo, Eloy A., Soria Saavedra, Francisco M., Mercado Villegas, Maria B., López Alvarado, Alejandra, Regla-Nava, Jose Angel, Torres-Valadez, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695305/
https://www.ncbi.nlm.nih.gov/pubmed/36422612
http://dx.doi.org/10.3390/pathogens11111360
_version_ 1784838023319388160
author Zepeda-Carrillo, Eloy A.
Soria Saavedra, Francisco M.
Mercado Villegas, Maria B.
López Alvarado, Alejandra
Regla-Nava, Jose Angel
Torres-Valadez, Rafael
author_facet Zepeda-Carrillo, Eloy A.
Soria Saavedra, Francisco M.
Mercado Villegas, Maria B.
López Alvarado, Alejandra
Regla-Nava, Jose Angel
Torres-Valadez, Rafael
author_sort Zepeda-Carrillo, Eloy A.
collection PubMed
description Mexico is an endemic region for dengue virus (DENV). The increase in this disease coincides with outbreaks of COVID-19, both of which are single-stranded positive RNA viruses. These characteristics make it difficult to distinguish each disease because they share clinical and laboratory features, which can consequently result in misdiagnoses. This is why the use of precision confirmatory tests (qRT-PCR) are crucial for early diagnosis. We herein report a pediatric patient who presented a coinfection for DENV and COVID-19, “SARS-CoV-2/Dengue”. This patient initially presented a fever, cough, and headache and, three days later, developed generalized pain and epistaxis. Blood studies revealed thrombocytopenia and leukopenia, and the patient was admitted to the hospital for a probable DENV infection. Within 48 h, qRT-PCR tests specific for SARS-CoV-2 and DENV were performed and resulted as positive. The patient immediately received pharmacological treatment with azithromycin, oseltamivir, and metamizole. During hospitalization (9 days), the patient had no signs of respiratory distress and maintained normal body temperature and normal blood oxygen saturation. This case warns of the need for early diagnosis and adequate clinical and pharmacological management in the face of a “SARS-CoV-2/Dengue” coinfection. Early molecular detection of both viruses and timely treatment helped the patient to achieve a favorable recovery.
format Online
Article
Text
id pubmed-9695305
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96953052022-11-26 SARS-CoV-2 and Dengue Virus Coinfection in a Mexican Pediatric Patient: A Case Report from Early Molecular Diagnosis Zepeda-Carrillo, Eloy A. Soria Saavedra, Francisco M. Mercado Villegas, Maria B. López Alvarado, Alejandra Regla-Nava, Jose Angel Torres-Valadez, Rafael Pathogens Case Report Mexico is an endemic region for dengue virus (DENV). The increase in this disease coincides with outbreaks of COVID-19, both of which are single-stranded positive RNA viruses. These characteristics make it difficult to distinguish each disease because they share clinical and laboratory features, which can consequently result in misdiagnoses. This is why the use of precision confirmatory tests (qRT-PCR) are crucial for early diagnosis. We herein report a pediatric patient who presented a coinfection for DENV and COVID-19, “SARS-CoV-2/Dengue”. This patient initially presented a fever, cough, and headache and, three days later, developed generalized pain and epistaxis. Blood studies revealed thrombocytopenia and leukopenia, and the patient was admitted to the hospital for a probable DENV infection. Within 48 h, qRT-PCR tests specific for SARS-CoV-2 and DENV were performed and resulted as positive. The patient immediately received pharmacological treatment with azithromycin, oseltamivir, and metamizole. During hospitalization (9 days), the patient had no signs of respiratory distress and maintained normal body temperature and normal blood oxygen saturation. This case warns of the need for early diagnosis and adequate clinical and pharmacological management in the face of a “SARS-CoV-2/Dengue” coinfection. Early molecular detection of both viruses and timely treatment helped the patient to achieve a favorable recovery. MDPI 2022-11-16 /pmc/articles/PMC9695305/ /pubmed/36422612 http://dx.doi.org/10.3390/pathogens11111360 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Zepeda-Carrillo, Eloy A.
Soria Saavedra, Francisco M.
Mercado Villegas, Maria B.
López Alvarado, Alejandra
Regla-Nava, Jose Angel
Torres-Valadez, Rafael
SARS-CoV-2 and Dengue Virus Coinfection in a Mexican Pediatric Patient: A Case Report from Early Molecular Diagnosis
title SARS-CoV-2 and Dengue Virus Coinfection in a Mexican Pediatric Patient: A Case Report from Early Molecular Diagnosis
title_full SARS-CoV-2 and Dengue Virus Coinfection in a Mexican Pediatric Patient: A Case Report from Early Molecular Diagnosis
title_fullStr SARS-CoV-2 and Dengue Virus Coinfection in a Mexican Pediatric Patient: A Case Report from Early Molecular Diagnosis
title_full_unstemmed SARS-CoV-2 and Dengue Virus Coinfection in a Mexican Pediatric Patient: A Case Report from Early Molecular Diagnosis
title_short SARS-CoV-2 and Dengue Virus Coinfection in a Mexican Pediatric Patient: A Case Report from Early Molecular Diagnosis
title_sort sars-cov-2 and dengue virus coinfection in a mexican pediatric patient: a case report from early molecular diagnosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695305/
https://www.ncbi.nlm.nih.gov/pubmed/36422612
http://dx.doi.org/10.3390/pathogens11111360
work_keys_str_mv AT zepedacarrilloeloya sarscov2anddengueviruscoinfectioninamexicanpediatricpatientacasereportfromearlymoleculardiagnosis
AT soriasaavedrafranciscom sarscov2anddengueviruscoinfectioninamexicanpediatricpatientacasereportfromearlymoleculardiagnosis
AT mercadovillegasmariab sarscov2anddengueviruscoinfectioninamexicanpediatricpatientacasereportfromearlymoleculardiagnosis
AT lopezalvaradoalejandra sarscov2anddengueviruscoinfectioninamexicanpediatricpatientacasereportfromearlymoleculardiagnosis
AT reglanavajoseangel sarscov2anddengueviruscoinfectioninamexicanpediatricpatientacasereportfromearlymoleculardiagnosis
AT torresvaladezrafael sarscov2anddengueviruscoinfectioninamexicanpediatricpatientacasereportfromearlymoleculardiagnosis