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Self−Assembling Anchorage of Hyaluronic Acid on the Nanoparticle Surface Confers Superiority of Triple Negative Breast Cancer Treatment

Triple-negative breast cancer (TNBC) has been listed as one of the most fatal diseases, and no effective targeting treatment is clinically available. Although CD44-targeting hyaluronic acid (HA) has been utilized as targeting ligands in many studies, no facile ways have been developed through HA sel...

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Autores principales: Li, Yingpeng, Liu, Liang, Shang, Hongtao, Feng, Xuchen, Fan, Ni, Wang, Jingyu, Wu, Yuqi, Chen, Yatong, Chu, Xinhong, Zhong, Min, Sun, Yujiao, Fu, Hui, Huang, Wei, Li, Yunfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695327/
https://www.ncbi.nlm.nih.gov/pubmed/36432652
http://dx.doi.org/10.3390/pharmaceutics14112461
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author Li, Yingpeng
Liu, Liang
Shang, Hongtao
Feng, Xuchen
Fan, Ni
Wang, Jingyu
Wu, Yuqi
Chen, Yatong
Chu, Xinhong
Zhong, Min
Sun, Yujiao
Fu, Hui
Huang, Wei
Li, Yunfei
author_facet Li, Yingpeng
Liu, Liang
Shang, Hongtao
Feng, Xuchen
Fan, Ni
Wang, Jingyu
Wu, Yuqi
Chen, Yatong
Chu, Xinhong
Zhong, Min
Sun, Yujiao
Fu, Hui
Huang, Wei
Li, Yunfei
author_sort Li, Yingpeng
collection PubMed
description Triple-negative breast cancer (TNBC) has been listed as one of the most fatal diseases, and no effective targeting treatment is clinically available. Although CD44-targeting hyaluronic acid (HA) has been utilized as targeting ligands in many studies, no facile ways have been developed through HA self-assembly at the nanoparticle surface. Herein, we reported N-isopropylacrylamide-grafted chitosan-based nanoparticles self-assembling with HA (HA-NPs) through electrostatic forces and loaded with curcumin (CUR). The HA-NPs displayed pH-responsive properties due to the chemical modification of chitosan, and the preparation process was optimized by central composite design–response surface methodology. HA anchorage confers the vehicle with tumor-targeting capability. HA-NPs displayed more robust effects of inhibiting TNBC primary tumor growth than free CUR and a plain counterpart but without increased systemic cytotoxicity. In addition, in vivo pharmacokinetic studies showed that HA-NPs significantly increased the in vivo residence time of free CUR and improved the bioavailability of CUR. These findings suggested that chitosan-based HA-NPs may provide a feasible and unique strategy to achieve CD44 targeting and enhance its efficacy in vivo for the treatment of advanced TNBC.
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spelling pubmed-96953272022-11-26 Self−Assembling Anchorage of Hyaluronic Acid on the Nanoparticle Surface Confers Superiority of Triple Negative Breast Cancer Treatment Li, Yingpeng Liu, Liang Shang, Hongtao Feng, Xuchen Fan, Ni Wang, Jingyu Wu, Yuqi Chen, Yatong Chu, Xinhong Zhong, Min Sun, Yujiao Fu, Hui Huang, Wei Li, Yunfei Pharmaceutics Article Triple-negative breast cancer (TNBC) has been listed as one of the most fatal diseases, and no effective targeting treatment is clinically available. Although CD44-targeting hyaluronic acid (HA) has been utilized as targeting ligands in many studies, no facile ways have been developed through HA self-assembly at the nanoparticle surface. Herein, we reported N-isopropylacrylamide-grafted chitosan-based nanoparticles self-assembling with HA (HA-NPs) through electrostatic forces and loaded with curcumin (CUR). The HA-NPs displayed pH-responsive properties due to the chemical modification of chitosan, and the preparation process was optimized by central composite design–response surface methodology. HA anchorage confers the vehicle with tumor-targeting capability. HA-NPs displayed more robust effects of inhibiting TNBC primary tumor growth than free CUR and a plain counterpart but without increased systemic cytotoxicity. In addition, in vivo pharmacokinetic studies showed that HA-NPs significantly increased the in vivo residence time of free CUR and improved the bioavailability of CUR. These findings suggested that chitosan-based HA-NPs may provide a feasible and unique strategy to achieve CD44 targeting and enhance its efficacy in vivo for the treatment of advanced TNBC. MDPI 2022-11-15 /pmc/articles/PMC9695327/ /pubmed/36432652 http://dx.doi.org/10.3390/pharmaceutics14112461 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Yingpeng
Liu, Liang
Shang, Hongtao
Feng, Xuchen
Fan, Ni
Wang, Jingyu
Wu, Yuqi
Chen, Yatong
Chu, Xinhong
Zhong, Min
Sun, Yujiao
Fu, Hui
Huang, Wei
Li, Yunfei
Self−Assembling Anchorage of Hyaluronic Acid on the Nanoparticle Surface Confers Superiority of Triple Negative Breast Cancer Treatment
title Self−Assembling Anchorage of Hyaluronic Acid on the Nanoparticle Surface Confers Superiority of Triple Negative Breast Cancer Treatment
title_full Self−Assembling Anchorage of Hyaluronic Acid on the Nanoparticle Surface Confers Superiority of Triple Negative Breast Cancer Treatment
title_fullStr Self−Assembling Anchorage of Hyaluronic Acid on the Nanoparticle Surface Confers Superiority of Triple Negative Breast Cancer Treatment
title_full_unstemmed Self−Assembling Anchorage of Hyaluronic Acid on the Nanoparticle Surface Confers Superiority of Triple Negative Breast Cancer Treatment
title_short Self−Assembling Anchorage of Hyaluronic Acid on the Nanoparticle Surface Confers Superiority of Triple Negative Breast Cancer Treatment
title_sort self−assembling anchorage of hyaluronic acid on the nanoparticle surface confers superiority of triple negative breast cancer treatment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695327/
https://www.ncbi.nlm.nih.gov/pubmed/36432652
http://dx.doi.org/10.3390/pharmaceutics14112461
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