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Label-Free Assessment of Mannitol Accumulation Following Osmotic Blood–Brain Barrier Opening Using Chemical Exchange Saturation Transfer Magnetic Resonance Imaging

Purpose: Mannitol is a hyperosmolar agent for reducing intracranial pressure and inducing osmotic blood–brain barrier opening (OBBBO). There is a great clinical need for a non-invasive method to optimize the safety of mannitol dosing. The aim of this study was to develop a label-free Chemical Exchan...

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Detalles Bibliográficos
Autores principales:	Liu, Jing, Chu, Chengyan, Zhang, Jia, Bie, Chongxue, Chen, Lin, Aafreen, Safiya, Xu, Jiadi, Kamson, David O., van Zijl, Peter C. M., Walczak, Piotr, Janowski, Miroslaw, Liu, Guanshu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695341/ https://www.ncbi.nlm.nih.gov/pubmed/36432721 http://dx.doi.org/10.3390/pharmaceutics14112529

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