Breakthrough SARS-CoV-2 Infections after Vaccination in North Carolina

We characterize the overall incidence and risk factors for breakthrough infection among fully vaccinated participants in the North Carolina COVID-19 Community Research Partnership cohort. Among 15,808 eligible participants, 638 reported a positive SARS-CoV-2 test after vaccination. Factors associate...

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Detalles Bibliográficos
Autores principales: Uschner, Diane, Bott, Matthew, Lagarde, William H., Keating, Joseph, Tapp, Hazel, Berry, Andrea A., Seals, Austin L., Munawar, Iqra, Schieffelin, John, Yukich, Joshua, Santacatterina, Michele, Gunaratne, Mihili, Fette, Lida M., Burke, Brian, Strylewicz, Greg, Edelstein, Sharon L., Ahmed, Amina, Miller, Kristen, Sanders, John W., Herrington, David, Weintraub, William S., Runyon, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695352/
https://www.ncbi.nlm.nih.gov/pubmed/36423018
http://dx.doi.org/10.3390/vaccines10111922
Descripción
Sumario:We characterize the overall incidence and risk factors for breakthrough infection among fully vaccinated participants in the North Carolina COVID-19 Community Research Partnership cohort. Among 15,808 eligible participants, 638 reported a positive SARS-CoV-2 test after vaccination. Factors associated with a lower risk of breakthrough in the time-to-event analysis included older age, prior SARS-CovV-2 infection, higher rates of face mask use, and receipt of a booster vaccination. Higher rates of breakthrough were reported by participants vaccinated with BNT162b2 or Ad26.COV2.S compared to mRNA-1273, in suburban or rural counties compared to urban counties, and during circulation of the Delta and Omicron variants.

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