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Breakthrough SARS-CoV-2 Infections after Vaccination in North Carolina
We characterize the overall incidence and risk factors for breakthrough infection among fully vaccinated participants in the North Carolina COVID-19 Community Research Partnership cohort. Among 15,808 eligible participants, 638 reported a positive SARS-CoV-2 test after vaccination. Factors associate...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695352/ https://www.ncbi.nlm.nih.gov/pubmed/36423018 http://dx.doi.org/10.3390/vaccines10111922 |
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| author | Uschner, Diane Bott, Matthew Lagarde, William H. Keating, Joseph Tapp, Hazel Berry, Andrea A. Seals, Austin L. Munawar, Iqra Schieffelin, John Yukich, Joshua Santacatterina, Michele Gunaratne, Mihili Fette, Lida M. Burke, Brian Strylewicz, Greg Edelstein, Sharon L. Ahmed, Amina Miller, Kristen Sanders, John W. Herrington, David Weintraub, William S. Runyon, Michael S. |
| author_facet | Uschner, Diane Bott, Matthew Lagarde, William H. Keating, Joseph Tapp, Hazel Berry, Andrea A. Seals, Austin L. Munawar, Iqra Schieffelin, John Yukich, Joshua Santacatterina, Michele Gunaratne, Mihili Fette, Lida M. Burke, Brian Strylewicz, Greg Edelstein, Sharon L. Ahmed, Amina Miller, Kristen Sanders, John W. Herrington, David Weintraub, William S. Runyon, Michael S. |
| author_sort | Uschner, Diane |
| collection | PubMed |
| description | We characterize the overall incidence and risk factors for breakthrough infection among fully vaccinated participants in the North Carolina COVID-19 Community Research Partnership cohort. Among 15,808 eligible participants, 638 reported a positive SARS-CoV-2 test after vaccination. Factors associated with a lower risk of breakthrough in the time-to-event analysis included older age, prior SARS-CovV-2 infection, higher rates of face mask use, and receipt of a booster vaccination. Higher rates of breakthrough were reported by participants vaccinated with BNT162b2 or Ad26.COV2.S compared to mRNA-1273, in suburban or rural counties compared to urban counties, and during circulation of the Delta and Omicron variants. |
| format | Online Article Text |
| id | pubmed-9695352 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-96953522022-11-26 Breakthrough SARS-CoV-2 Infections after Vaccination in North Carolina Uschner, Diane Bott, Matthew Lagarde, William H. Keating, Joseph Tapp, Hazel Berry, Andrea A. Seals, Austin L. Munawar, Iqra Schieffelin, John Yukich, Joshua Santacatterina, Michele Gunaratne, Mihili Fette, Lida M. Burke, Brian Strylewicz, Greg Edelstein, Sharon L. Ahmed, Amina Miller, Kristen Sanders, John W. Herrington, David Weintraub, William S. Runyon, Michael S. Vaccines (Basel) Brief Report We characterize the overall incidence and risk factors for breakthrough infection among fully vaccinated participants in the North Carolina COVID-19 Community Research Partnership cohort. Among 15,808 eligible participants, 638 reported a positive SARS-CoV-2 test after vaccination. Factors associated with a lower risk of breakthrough in the time-to-event analysis included older age, prior SARS-CovV-2 infection, higher rates of face mask use, and receipt of a booster vaccination. Higher rates of breakthrough were reported by participants vaccinated with BNT162b2 or Ad26.COV2.S compared to mRNA-1273, in suburban or rural counties compared to urban counties, and during circulation of the Delta and Omicron variants. MDPI 2022-11-13 /pmc/articles/PMC9695352/ /pubmed/36423018 http://dx.doi.org/10.3390/vaccines10111922 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Brief Report Uschner, Diane Bott, Matthew Lagarde, William H. Keating, Joseph Tapp, Hazel Berry, Andrea A. Seals, Austin L. Munawar, Iqra Schieffelin, John Yukich, Joshua Santacatterina, Michele Gunaratne, Mihili Fette, Lida M. Burke, Brian Strylewicz, Greg Edelstein, Sharon L. Ahmed, Amina Miller, Kristen Sanders, John W. Herrington, David Weintraub, William S. Runyon, Michael S. Breakthrough SARS-CoV-2 Infections after Vaccination in North Carolina |
| title | Breakthrough SARS-CoV-2 Infections after Vaccination in North Carolina |
| title_full | Breakthrough SARS-CoV-2 Infections after Vaccination in North Carolina |
| title_fullStr | Breakthrough SARS-CoV-2 Infections after Vaccination in North Carolina |
| title_full_unstemmed | Breakthrough SARS-CoV-2 Infections after Vaccination in North Carolina |
| title_short | Breakthrough SARS-CoV-2 Infections after Vaccination in North Carolina |
| title_sort | breakthrough sars-cov-2 infections after vaccination in north carolina |
| topic | Brief Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695352/ https://www.ncbi.nlm.nih.gov/pubmed/36423018 http://dx.doi.org/10.3390/vaccines10111922 |
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