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Mechanism Underlying Metformin Action and Its Potential to Reduce Gastric Cancer Risk
Diabetes mellitus is associated with a high risk of developing gastric cancer (GC). Metformin, which is conventionally used to treat type 2 diabetes, induces AMP-activated protein kinase signaling and suppresses gluconeogenesis. Recent studies have reported that metformin is associated with benefici...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695469/ https://www.ncbi.nlm.nih.gov/pubmed/36430639 http://dx.doi.org/10.3390/ijms232214163 |
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author | Lan, Wen-Hsi Lin, Ting-Yu Yeh, Jia-Ai Feng, Chun-Lung Hsu, Jun-Te Lin, Hwai-Jeng Kuo, Chia-Jung Lai, Chih-Ho |
author_facet | Lan, Wen-Hsi Lin, Ting-Yu Yeh, Jia-Ai Feng, Chun-Lung Hsu, Jun-Te Lin, Hwai-Jeng Kuo, Chia-Jung Lai, Chih-Ho |
author_sort | Lan, Wen-Hsi |
collection | PubMed |
description | Diabetes mellitus is associated with a high risk of developing gastric cancer (GC). Metformin, which is conventionally used to treat type 2 diabetes, induces AMP-activated protein kinase signaling and suppresses gluconeogenesis. Recent studies have reported that metformin is associated with beneficial effects in cancer prevention and treatment owing to its anti-tumor effects. This makes metformin a potential medication for GC therapy. However, contradicting reports have emerged regarding the efficacy of metformin in reducing the risk of GC. This review summarizes the impact of metformin on mitigating GC risk by analyzing clinical databases. The mechanism underlying the anti-tumor effect of metformin on GC is also discussed. |
format | Online Article Text |
id | pubmed-9695469 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96954692022-11-26 Mechanism Underlying Metformin Action and Its Potential to Reduce Gastric Cancer Risk Lan, Wen-Hsi Lin, Ting-Yu Yeh, Jia-Ai Feng, Chun-Lung Hsu, Jun-Te Lin, Hwai-Jeng Kuo, Chia-Jung Lai, Chih-Ho Int J Mol Sci Review Diabetes mellitus is associated with a high risk of developing gastric cancer (GC). Metformin, which is conventionally used to treat type 2 diabetes, induces AMP-activated protein kinase signaling and suppresses gluconeogenesis. Recent studies have reported that metformin is associated with beneficial effects in cancer prevention and treatment owing to its anti-tumor effects. This makes metformin a potential medication for GC therapy. However, contradicting reports have emerged regarding the efficacy of metformin in reducing the risk of GC. This review summarizes the impact of metformin on mitigating GC risk by analyzing clinical databases. The mechanism underlying the anti-tumor effect of metformin on GC is also discussed. MDPI 2022-11-16 /pmc/articles/PMC9695469/ /pubmed/36430639 http://dx.doi.org/10.3390/ijms232214163 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lan, Wen-Hsi Lin, Ting-Yu Yeh, Jia-Ai Feng, Chun-Lung Hsu, Jun-Te Lin, Hwai-Jeng Kuo, Chia-Jung Lai, Chih-Ho Mechanism Underlying Metformin Action and Its Potential to Reduce Gastric Cancer Risk |
title | Mechanism Underlying Metformin Action and Its Potential to Reduce Gastric Cancer Risk |
title_full | Mechanism Underlying Metformin Action and Its Potential to Reduce Gastric Cancer Risk |
title_fullStr | Mechanism Underlying Metformin Action and Its Potential to Reduce Gastric Cancer Risk |
title_full_unstemmed | Mechanism Underlying Metformin Action and Its Potential to Reduce Gastric Cancer Risk |
title_short | Mechanism Underlying Metformin Action and Its Potential to Reduce Gastric Cancer Risk |
title_sort | mechanism underlying metformin action and its potential to reduce gastric cancer risk |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695469/ https://www.ncbi.nlm.nih.gov/pubmed/36430639 http://dx.doi.org/10.3390/ijms232214163 |
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