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Porcine Epidemic Diarrhea Virus: An Updated Overview of Virus Epidemiology, Virulence Variation Patterns and Virus–Host Interactions

The porcine epidemic diarrhea virus (PEDV) is a member of the coronavirus family, causing deadly watery diarrhea in newborn piglets. The global pandemic of PEDV, with significant morbidity and mortality, poses a huge threat to the swine industry. The currently developed vaccines and drugs are only e...

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Autores principales: Zhang, Yuanzhu, Chen, Yiwu, Zhou, Jian, Wang, Xi, Ma, Lerong, Li, Jianing, Yang, Lin, Yuan, Hongming, Pang, Daxin, Ouyang, Hongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695474/
https://www.ncbi.nlm.nih.gov/pubmed/36366532
http://dx.doi.org/10.3390/v14112434
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author Zhang, Yuanzhu
Chen, Yiwu
Zhou, Jian
Wang, Xi
Ma, Lerong
Li, Jianing
Yang, Lin
Yuan, Hongming
Pang, Daxin
Ouyang, Hongsheng
author_facet Zhang, Yuanzhu
Chen, Yiwu
Zhou, Jian
Wang, Xi
Ma, Lerong
Li, Jianing
Yang, Lin
Yuan, Hongming
Pang, Daxin
Ouyang, Hongsheng
author_sort Zhang, Yuanzhu
collection PubMed
description The porcine epidemic diarrhea virus (PEDV) is a member of the coronavirus family, causing deadly watery diarrhea in newborn piglets. The global pandemic of PEDV, with significant morbidity and mortality, poses a huge threat to the swine industry. The currently developed vaccines and drugs are only effective against the classic GI strains that were prevalent before 2010, while there is no effective control against the GII variant strains that are currently a global pandemic. In this review, we summarize the latest progress in the biology of PEDV, including its transmission and origin, structure and function, evolution, and virus–host interaction, in an attempt to find the potential virulence factors influencing PEDV pathogenesis. We conclude with the mechanism by which PEDV components antagonize the immune responses of the virus, and the role of host factors in virus infection. Essentially, this review serves as a valuable reference for the development of attenuated virus vaccines and the potential of host factors as antiviral targets for the prevention and control of PEDV infection.
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spelling pubmed-96954742022-11-26 Porcine Epidemic Diarrhea Virus: An Updated Overview of Virus Epidemiology, Virulence Variation Patterns and Virus–Host Interactions Zhang, Yuanzhu Chen, Yiwu Zhou, Jian Wang, Xi Ma, Lerong Li, Jianing Yang, Lin Yuan, Hongming Pang, Daxin Ouyang, Hongsheng Viruses Review The porcine epidemic diarrhea virus (PEDV) is a member of the coronavirus family, causing deadly watery diarrhea in newborn piglets. The global pandemic of PEDV, with significant morbidity and mortality, poses a huge threat to the swine industry. The currently developed vaccines and drugs are only effective against the classic GI strains that were prevalent before 2010, while there is no effective control against the GII variant strains that are currently a global pandemic. In this review, we summarize the latest progress in the biology of PEDV, including its transmission and origin, structure and function, evolution, and virus–host interaction, in an attempt to find the potential virulence factors influencing PEDV pathogenesis. We conclude with the mechanism by which PEDV components antagonize the immune responses of the virus, and the role of host factors in virus infection. Essentially, this review serves as a valuable reference for the development of attenuated virus vaccines and the potential of host factors as antiviral targets for the prevention and control of PEDV infection. MDPI 2022-11-02 /pmc/articles/PMC9695474/ /pubmed/36366532 http://dx.doi.org/10.3390/v14112434 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Yuanzhu
Chen, Yiwu
Zhou, Jian
Wang, Xi
Ma, Lerong
Li, Jianing
Yang, Lin
Yuan, Hongming
Pang, Daxin
Ouyang, Hongsheng
Porcine Epidemic Diarrhea Virus: An Updated Overview of Virus Epidemiology, Virulence Variation Patterns and Virus–Host Interactions
title Porcine Epidemic Diarrhea Virus: An Updated Overview of Virus Epidemiology, Virulence Variation Patterns and Virus–Host Interactions
title_full Porcine Epidemic Diarrhea Virus: An Updated Overview of Virus Epidemiology, Virulence Variation Patterns and Virus–Host Interactions
title_fullStr Porcine Epidemic Diarrhea Virus: An Updated Overview of Virus Epidemiology, Virulence Variation Patterns and Virus–Host Interactions
title_full_unstemmed Porcine Epidemic Diarrhea Virus: An Updated Overview of Virus Epidemiology, Virulence Variation Patterns and Virus–Host Interactions
title_short Porcine Epidemic Diarrhea Virus: An Updated Overview of Virus Epidemiology, Virulence Variation Patterns and Virus–Host Interactions
title_sort porcine epidemic diarrhea virus: an updated overview of virus epidemiology, virulence variation patterns and virus–host interactions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695474/
https://www.ncbi.nlm.nih.gov/pubmed/36366532
http://dx.doi.org/10.3390/v14112434
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