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Associations between Cardiovascular Outcomes and Rheumatoid Arthritis: A Nationwide Population-Based Cohort Study

Despite a growing burden posed by cardiovascular disease (CVD) in rheumatoid arthritis (RA) patients, large-scale studies on the association between the characteristics of RA patients and CVD risks and studies adjusted for various confounding factors are lacking. In this large-scale nationwide cohor...

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Autores principales: Kang, Seonyoung, Han, Kyungdo, Jung, Jin-Hyung, Eun, Yeonghee, Kim, In Young, Hwang, Jiwon, Koh, Eun-Mi, Lee, Seulkee, Cha, Hoon-Suk, Kim, Hyungjin, Lee, Jaejoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695475/
https://www.ncbi.nlm.nih.gov/pubmed/36431290
http://dx.doi.org/10.3390/jcm11226812
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author Kang, Seonyoung
Han, Kyungdo
Jung, Jin-Hyung
Eun, Yeonghee
Kim, In Young
Hwang, Jiwon
Koh, Eun-Mi
Lee, Seulkee
Cha, Hoon-Suk
Kim, Hyungjin
Lee, Jaejoon
author_facet Kang, Seonyoung
Han, Kyungdo
Jung, Jin-Hyung
Eun, Yeonghee
Kim, In Young
Hwang, Jiwon
Koh, Eun-Mi
Lee, Seulkee
Cha, Hoon-Suk
Kim, Hyungjin
Lee, Jaejoon
author_sort Kang, Seonyoung
collection PubMed
description Despite a growing burden posed by cardiovascular disease (CVD) in rheumatoid arthritis (RA) patients, large-scale studies on the association between the characteristics of RA patients and CVD risks and studies adjusted for various confounding factors are lacking. In this large-scale nationwide cohort study, we aimed to investigate the association between CVD risk and RA and factors that may increase CVD risk using a dataset provided by the Korean National Health Insurance Service (NHIS). We enrolled 136,469 patients with RA who participated in national health examinations within two years of RA diagnosis between 2010 and 2017 and non-RA controls matched by age and sex (n = 682,345). The outcome was the occurrence of myocardial infarction (MI) or stroke. MI was defined as one hospitalization or two outpatient visits with ICD-10-CM codes I21 or I22. Stroke was defined as one hospitalization with ICD-10-CM codes I63 or I64 and a claim for brain imaging (CT or MRI). The Cox proportional hazard model and Kaplan–Meier curve were used for analysis. The mean follow-up duration was 4.7 years, and the incidence rate of CVD was higher in the RA group than the control group (MI: 3.20 vs. 2.08; stroke: 2.84 vs. 2.33 per 1000 person-years). The risk of MI and stroke was about 50% and 20% higher, respectively, in RA patients. The association between RA and CVD was prominent in females after adjusting for confounding variables. The association between RA and risk of MI was significant in individuals without DM. Therefore, appropriate screening for CVD is important in all RA patients including females and younger patients.
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spelling pubmed-96954752022-11-26 Associations between Cardiovascular Outcomes and Rheumatoid Arthritis: A Nationwide Population-Based Cohort Study Kang, Seonyoung Han, Kyungdo Jung, Jin-Hyung Eun, Yeonghee Kim, In Young Hwang, Jiwon Koh, Eun-Mi Lee, Seulkee Cha, Hoon-Suk Kim, Hyungjin Lee, Jaejoon J Clin Med Article Despite a growing burden posed by cardiovascular disease (CVD) in rheumatoid arthritis (RA) patients, large-scale studies on the association between the characteristics of RA patients and CVD risks and studies adjusted for various confounding factors are lacking. In this large-scale nationwide cohort study, we aimed to investigate the association between CVD risk and RA and factors that may increase CVD risk using a dataset provided by the Korean National Health Insurance Service (NHIS). We enrolled 136,469 patients with RA who participated in national health examinations within two years of RA diagnosis between 2010 and 2017 and non-RA controls matched by age and sex (n = 682,345). The outcome was the occurrence of myocardial infarction (MI) or stroke. MI was defined as one hospitalization or two outpatient visits with ICD-10-CM codes I21 or I22. Stroke was defined as one hospitalization with ICD-10-CM codes I63 or I64 and a claim for brain imaging (CT or MRI). The Cox proportional hazard model and Kaplan–Meier curve were used for analysis. The mean follow-up duration was 4.7 years, and the incidence rate of CVD was higher in the RA group than the control group (MI: 3.20 vs. 2.08; stroke: 2.84 vs. 2.33 per 1000 person-years). The risk of MI and stroke was about 50% and 20% higher, respectively, in RA patients. The association between RA and CVD was prominent in females after adjusting for confounding variables. The association between RA and risk of MI was significant in individuals without DM. Therefore, appropriate screening for CVD is important in all RA patients including females and younger patients. MDPI 2022-11-17 /pmc/articles/PMC9695475/ /pubmed/36431290 http://dx.doi.org/10.3390/jcm11226812 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kang, Seonyoung
Han, Kyungdo
Jung, Jin-Hyung
Eun, Yeonghee
Kim, In Young
Hwang, Jiwon
Koh, Eun-Mi
Lee, Seulkee
Cha, Hoon-Suk
Kim, Hyungjin
Lee, Jaejoon
Associations between Cardiovascular Outcomes and Rheumatoid Arthritis: A Nationwide Population-Based Cohort Study
title Associations between Cardiovascular Outcomes and Rheumatoid Arthritis: A Nationwide Population-Based Cohort Study
title_full Associations between Cardiovascular Outcomes and Rheumatoid Arthritis: A Nationwide Population-Based Cohort Study
title_fullStr Associations between Cardiovascular Outcomes and Rheumatoid Arthritis: A Nationwide Population-Based Cohort Study
title_full_unstemmed Associations between Cardiovascular Outcomes and Rheumatoid Arthritis: A Nationwide Population-Based Cohort Study
title_short Associations between Cardiovascular Outcomes and Rheumatoid Arthritis: A Nationwide Population-Based Cohort Study
title_sort associations between cardiovascular outcomes and rheumatoid arthritis: a nationwide population-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695475/
https://www.ncbi.nlm.nih.gov/pubmed/36431290
http://dx.doi.org/10.3390/jcm11226812
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