Exploring Membrane Binding Targets of Disordered Human Tau Aggregates on Lipid Rafts Using Multiscale Molecular Dynamics Simulations

The self-aggregation of tau, a microtubule-binding protein, has been linked to the onset of Alzheimer’s Disease. Recent studies indicate that the disordered tau aggregates, or oligomers, are more toxic than the ordered fibrils found in the intracellular neurofibrillary tangles of tau. At present, de...

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Detalles Bibliográficos
Autores principales: Cheng, Kwan H., Graf, Angela, Lewis, Amber, Pham, Thuong, Acharya, Aakriti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695534/
https://www.ncbi.nlm.nih.gov/pubmed/36363654
http://dx.doi.org/10.3390/membranes12111098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695534/
https://www.ncbi.nlm.nih.gov/pubmed/36363654
http://dx.doi.org/10.3390/membranes12111098

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