Discovery of Levesquamide B through Global Natural Product Social Molecular Networking

Levesquamide A is an isothiazolinone-containing anti-tubercular natural product isolated from Streptomyces sp. RKND-216. Through the use of Global Natural Product Social Molecular Networking (GNPS), additional members of the levesquamide family were identified (B-G). Levesquamide B is a glycosylated...

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Detalles Bibliográficos
Autores principales: LeClair, Mary M., Maw, Zacharie A., Grunwald, Alyssa L., Kelly, Joshua R., Haltli, Bradley A., Kerr, Russell G., Cartmell, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695545/
https://www.ncbi.nlm.nih.gov/pubmed/36431895
http://dx.doi.org/10.3390/molecules27227794
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author LeClair, Mary M.
Maw, Zacharie A.
Grunwald, Alyssa L.
Kelly, Joshua R.
Haltli, Bradley A.
Kerr, Russell G.
Cartmell, Christopher
author_facet LeClair, Mary M.
Maw, Zacharie A.
Grunwald, Alyssa L.
Kelly, Joshua R.
Haltli, Bradley A.
Kerr, Russell G.
Cartmell, Christopher
author_sort LeClair, Mary M.
collection PubMed
description Levesquamide A is an isothiazolinone-containing anti-tubercular natural product isolated from Streptomyces sp. RKND-216. Through the use of Global Natural Product Social Molecular Networking (GNPS), additional members of the levesquamide family were identified (B-G). Levesquamide B is a glycosylated analogue, isolated and structurally elucidated via spectroscopical techniques along with the putative structures of levesquamide C and D. For masses relating to the additional three levesquamides (E-G), their complete structures remain ambiguous.
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spelling pubmed-96955452022-11-26 Discovery of Levesquamide B through Global Natural Product Social Molecular Networking LeClair, Mary M. Maw, Zacharie A. Grunwald, Alyssa L. Kelly, Joshua R. Haltli, Bradley A. Kerr, Russell G. Cartmell, Christopher Molecules Article Levesquamide A is an isothiazolinone-containing anti-tubercular natural product isolated from Streptomyces sp. RKND-216. Through the use of Global Natural Product Social Molecular Networking (GNPS), additional members of the levesquamide family were identified (B-G). Levesquamide B is a glycosylated analogue, isolated and structurally elucidated via spectroscopical techniques along with the putative structures of levesquamide C and D. For masses relating to the additional three levesquamides (E-G), their complete structures remain ambiguous. MDPI 2022-11-12 /pmc/articles/PMC9695545/ /pubmed/36431895 http://dx.doi.org/10.3390/molecules27227794 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
LeClair, Mary M.
Maw, Zacharie A.
Grunwald, Alyssa L.
Kelly, Joshua R.
Haltli, Bradley A.
Kerr, Russell G.
Cartmell, Christopher
Discovery of Levesquamide B through Global Natural Product Social Molecular Networking
title Discovery of Levesquamide B through Global Natural Product Social Molecular Networking
title_full Discovery of Levesquamide B through Global Natural Product Social Molecular Networking
title_fullStr Discovery of Levesquamide B through Global Natural Product Social Molecular Networking
title_full_unstemmed Discovery of Levesquamide B through Global Natural Product Social Molecular Networking
title_short Discovery of Levesquamide B through Global Natural Product Social Molecular Networking
title_sort discovery of levesquamide b through global natural product social molecular networking
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695545/
https://www.ncbi.nlm.nih.gov/pubmed/36431895
http://dx.doi.org/10.3390/molecules27227794
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