Cargando…

Vitamin B6 Inhibits High Glucose-Induced Islet β Cell Apoptosis by Upregulating Autophagy

Vitamin B6 may alleviate diabetes by regulating insulin secretion and increasing insulin sensitivity, but its mechanism remains to be explored. In this study, vitamin B6-mediated autophagy and high glucose-induced apoptosis were tested to investigate the mechanism by which vitamin B6 regulates insul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yu, Zhou, Xi-an, Liu, Chuxin, Shen, Qingwu, Wu, Yanyang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695582/ https://www.ncbi.nlm.nih.gov/pubmed/36355132 http://dx.doi.org/10.3390/metabo12111048

Ejemplares similares

Vitamin B12-Induced Autophagy Alleviates High Glucose-Mediated Apoptosis of Islet β Cells
por: Zhang, Yu, et al.
Publicado: (2023)

VEGF-B ablation in pancreatic β-cells upregulates insulin expression without affecting glucose homeostasis or islet lipid uptake
por: Ning, Frank Chenfei, et al.
Publicado: (2020)

EGCG Upregulates UCP(3) Levels to Protect MIN(6) Pancreatic Islet Cells from Interleukin-1β-Induced Apoptosis
por: Jia, Xu, et al.
Publicado: (2020)

MKP-5 Relieves Lipotoxicity-Induced Islet β-Cell Dysfunction and Apoptosis via Regulation of Autophagy
por: Zhao, Tongjian, et al.
Publicado: (2020)

Autophagy protects against human islet amyloid polypeptide‐associated apoptosis
por: Morita, Shuhei, et al.
Publicado: (2011)

Propofol Upregulates MicroRNA-30b to Inhibit Excessive Autophagy and Apoptosis and Attenuates Ischemia/Reperfusion Injury In Vitro and in Patients
por: Lu, Zhiqi, et al.
Publicado: (2022)

Genetic modulation of islet β-cell iPLA(2)β expression provides evidence for its impact on β-cell apoptosis and autophagy
por: Lei, Xiaoyong, et al.
Publicado: (2013)

Absorption and Transport Mechanism of Red Meat-Derived N-glycolylneuraminic Acid and Its Damage to Intestinal Barrier Function through the NF-κB Signaling Pathway
por: He, Enqi, et al.
Publicado: (2023)

Inhibition of peptidyl-prolyl cis-trans isomerase B mediates cyclosporin A-induced apoptosis of islet β cells
por: Wei, Xiao, et al.
Publicado: (2018)

Proteasome inhibition attenuates rasfonin-induced autophagy concurring with the upregulation of caspase-dependent apoptosis
por: Yan, Siyuan, et al.
Publicado: (2016)

Apoptosis Activation and Autophagy Inhibition of Chondrocytes by Leptin by the Upregulation of LOXL3 in Osteoarthritis Pathogenesis
por: Wei, Qianhao
Publicado: (2022)

Inhibition of autophagy promoted high glucose/ROS-mediated apoptosis in ADSCs
por: Li, Qiang, et al.
Publicado: (2018)

β-Ecdysterone promotes autophagy and inhibits apoptosis in osteoporotic rats
por: Tang, Yang-Hua, et al.
Publicado: (2018)

Islets and Glucose Homeostasis
por: Chang, Tien-Jyun, et al.
Publicado: (2015)

Glibenclamide-Induced Autophagy Inhibits Its Insulin Secretion-Improving Function in β Cells
por: Zhou, Jiali, et al.
Publicado: (2019)

Par-4/NF-κB Mediates the Apoptosis of Islet β Cells Induced by Glucolipotoxicity
por: QiNan, Wu, et al.
Publicado: (2016)

Amlodipine Improves Spinal Cord Injury Repair by Inhibiting Motoneuronal Apoptosis Through Autophagy Upregulation
por: Huang, Yang, et al.
Publicado: (2022)

SH2B1 in β-Cells Regulates Glucose Metabolism by Promoting β-Cell Survival and Islet Expansion
por: Chen, Zheng, et al.
Publicado: (2014)

Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice
por: Fields, Ashley M., et al.
Publicado: (2021)

Glucose and Inflammation Control Islet Vascular Density and β-Cell Function in NOD Mice: Control of Islet Vasculature and Vascular Endothelial Growth Factor by Glucose
por: Akirav, Eitan M., et al.
Publicado: (2011)

Glucose Regulates m(6)A Methylation of RNA in Pancreatic Islets
por: Bornaque, Florine, et al.
Publicado: (2022)

Glucose transporters in pancreatic islets
por: Berger, Constantin, et al.
Publicado: (2020)

Islet cilia and glucose homeostasis
por: Melena, Isabella, et al.
Publicado: (2022)

miR-124 is upregulated in diabetic mice and inhibits proliferation and promotes apoptosis of high-glucose-induced β-cells by targeting EZH2
por: Duan, Xiao-Kai, et al.
Publicado: (2023)

Assay for high glucose-mediated islet cell sensitization to apoptosis induced by streptozotocin and cytokines
por: Mellado-Gil, Jose M., et al.
Publicado: (2005)

Thymoquinone Preserves Pancreatic Islets Structure Through Upregulation of Pancreatic β-Catenin in Hypothyroid Rats
por: Faddladdeen, Khadija, et al.
Publicado: (2021)

Autophagy Upregulation and Apoptosis Downregulation in DAHP and Triptolide Treated Cerebral Ischemia
por: Yang, Yang, et al.
Publicado: (2015)

Mangiferin Facilitates Islet Regeneration and β-Cell Proliferation through Upregulation of Cell Cycle and β-Cell Regeneration Regulators
por: Wang, Hai-Lian, et al.
Publicado: (2014)

Cdc42 upregulation under high glucose induces podocyte apoptosis and impairs β-cell insulin secretion
por: Jiang, Shan, et al.
Publicado: (2022)

DNase I aggravates islet β-cell apoptosis in type 2 diabetes
por: ZHU, BIN, et al.
Publicado: (2016)

Proteasome Dysfunction Mediates High Glucose-Induced Apoptosis in Rodent Beta Cells and Human Islets
por: Broca, Christophe, et al.
Publicado: (2014)

Liraglutide inhibits autophagy and apoptosis induced by high glucose through GLP-1R in renal tubular epithelial cells
por: ZHAO, X, et al.
Publicado: (2015)

Redifferentiation of expanded human islet β cells by inhibition of ARX
por: Friedman-Mazursky, Orr, et al.
Publicado: (2016)

Identification of Circular RNAs Regulating Islet β-Cell Autophagy in Type 2 Diabetes Mellitus
por: Bai, Chao, et al.
Publicado: (2019)

Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet β cells
por: Kalwat, Michael A, et al.
Publicado: (2013)

A20 Inhibits Cytokine-Induced Apoptosis and Nuclear Factor κB–Dependent Gene Activation in Islets
por: Grey, Shane T., et al.
Publicado: (1999)

Vitamin B6 reduces hippocampal apoptosis in experimental pneumococcal meningitis
por: Zysset-Burri, Denise C, et al.
Publicado: (2013)

Recombinant Reg3α Prevents Islet β-Cell Apoptosis and Promotes β-Cell Regeneration
por: Yu, Luting, et al.
Publicado: (2022)

Modulation of Rab7a-mediated growth factor receptor trafficking inhibits islet beta cell apoptosis and autophagy under conditions of metabolic stress
por: Hewawasam, Nirun V., et al.
Publicado: (2020)

Apoptosis of Human Islet Cells by Cytokines
por: Kim, Sunshin, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_hls5gulsefs508pl1gu6fkcpat